HUMAN:UIMC1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	UIMC1 (synonyms: RAP80, RXRIP110)
Protein Name(s)	BRCA1-A complex subunit RAP80 Receptor-associated protein 80 Retinoid X receptor-interacting protein 110 Ubiquitin interaction motif-containing protein 1
External Links
UniProt	Q96RL1
EMBL	AF349313 AF113538 AF284749 AF284753 AK023044 AK304794 BX537376 AC027318 BC006078 BC032561
CCDS	CCDS4408.1
RefSeq	NP_001186226.1 NP_001186227.1 NP_057374.3 XP_005265987.1 XP_005265993.1 XP_006714934.1 XP_006714935.1 XP_006714936.1
UniGene	Hs.232721
PDB	2MKF 2MKG 2RR9
PDBsum	2MKF 2MKG 2RR9
ProteinModelPortal	Q96RL1
SMR	Q96RL1
BioGrid	119697
DIP	DIP-29936N
IntAct	Q96RL1
MINT	MINT-1197441
PhosphoSite	Q96RL1
DMDM	60390957
MaxQB	Q96RL1
PaxDb	Q96RL1
PRIDE	Q96RL1
DNASU	51720
Ensembl	ENST00000377227 ENST00000506128 ENST00000510698 ENST00000511320
GeneID	51720
KEGG	hsa:51720
UCSC	uc003mfd.2 uc011dfq.2 uc021yil.1
CTD	51720
GeneCards	GC05M176265
H-InvDB	HIX0005450
HGNC	HGNC:30298
HPA	HPA037503 HPA037504
MIM	609433
neXtProt	NX_Q96RL1
PharmGKB	PA162408624
eggNOG	NOG72551
GeneTree	ENSGT00390000007635
HOVERGEN	HBG056783
InParanoid	Q96RL1
OrthoDB	EOG74XS6K
PhylomeDB	Q96RL1
TreeFam	TF336575
ChiTaRS	UIMC1
EvolutionaryTrace	Q96RL1
GeneWiki	UIMC1
GenomeRNAi	51720
NextBio	55772
PRO	PR:Q96RL1
Proteomes	UP000005640
Bgee	Q96RL1
CleanEx	HS_UIMC1
ExpressionAtlas	Q96RL1
Genevestigator	Q96RL1
GO	GO:0070531 GO:0005634 GO:0042393 GO:0070530 GO:0006302 GO:0031572 GO:0070537 GO:0045892 GO:0045739 GO:0010212 GO:0006351
InterPro	IPR003903
SMART	SM00726
PROSITE	PS50330

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:12080054^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12080054^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0070537	histone H2A K63-linked deubiquitination	PMID:19202061^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	PMID:17525341^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	PMID:17525342^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	PMID:19261746^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	PMID:19261749^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	PMID:19261748^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	PMID:17525340^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PMID:22742833^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PMID:17525342^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PMID:19261749^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PMID:17525341^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	PMID:17525342^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	PMID:19261748^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	PMID:17525340^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	PMID:17643121^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	PMID:17525341^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:17525342^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:17525341^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	PMID:17525340^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	PMID:17643121^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	PMID:17525341^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	PMID:17525342^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	PMID:19261748^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	PMID:17525342^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	PMID:19261748^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	PMID:17525340^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	PMID:17643121^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	PMID:17525341^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:19261748^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:17643121^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:17525341^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:17525340^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:17525342^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17525342^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17525340^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17525341^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17643121^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0070537	histone H2A K63-linked deubiquitination	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001439928 UniProtKB:Q96RL1	P	Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001439928 UniProtKB:Q96RL1	C	Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001439928 UniProtKB:Q96RL1	F	Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001439928 UniProtKB:Q96RL1	P	Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001439928 UniProtKB:Q96RL1	F	Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001439928 UniProtKB:Q96RL1	P	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR038868	P	Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR038868	F	Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR038868	C	Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	Reactome:R-HSA-5693571	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-69891 Reactome:R-HSA-5693551 Reactome:R-HSA-5691411 Reactome:R-HSA-5686685 Reactome:R-HSA-5684071 Reactome:R-HSA-5684052 Reactome:R-HSA-5683801 Reactome:R-HSA-5683735 Reactome:R-HSA-5683385 Reactome:R-HSA-5683384	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yan, Z et al. (2002) RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor. J. Biol. Chem. 277 32379-88 PubMed GONUTS page
↑ Shao, G et al. (2009) The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks. Proc. Natl. Acad. Sci. U.S.A. 106 3166-71 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Sobhian, B et al. (2007) RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science 316 1198-202 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Kim, H et al. (2007) Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science 316 1202-5 PubMed GONUTS page
↑ Shao, G et al. (2009) MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. Genes Dev. 23 740-54 PubMed GONUTS page
↑ ^6.0 ^6.1 Wang, B et al. (2009) NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev. 23 729-39 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Feng, L et al. (2009) MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev. 23 719-28 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Wang, B et al. (2007) Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science 316 1194-8 PubMed GONUTS page
↑ Panier, S et al. (2012) Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks. Mol. Cell 47 383-95 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Liu, Z et al. (2007) CCDC98 targets BRCA1 to DNA damage sites. Nat. Struct. Mol. Biol. 14 716-20 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12080054-1] 1.0 ^1.1 Yan, Z et al. (2002) RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor. J. Biol. Chem. 277 32379-88 PubMed GONUTS page

[PMID:19202061-2] Shao, G et al. (2009) The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks. Proc. Natl. Acad. Sci. U.S.A. 106 3166-71 PubMed GONUTS page

[PMID:17525341-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Sobhian, B et al. (2007) RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science 316 1198-202 PubMed GONUTS page

[PMID:17525342-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Kim, H et al. (2007) Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science 316 1202-5 PubMed GONUTS page

[PMID:19261746-5] Shao, G et al. (2009) MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. Genes Dev. 23 740-54 PubMed GONUTS page

[PMID:19261749-6] 6.0 ^6.1 Wang, B et al. (2009) NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev. 23 729-39 PubMed GONUTS page

[PMID:19261748-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Feng, L et al. (2009) MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev. 23 719-28 PubMed GONUTS page

[PMID:17525340-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Wang, B et al. (2007) Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science 316 1194-8 PubMed GONUTS page

[PMID:22742833-9] Panier, S et al. (2012) Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks. Mol. Cell 47 383-95 PubMed GONUTS page

[PMID:17643121-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Liu, Z et al. (2007) CCDC98 targets BRCA1 to DNA damage sites. Nat. Struct. Mol. Biol. 14 716-20 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:UIMC1

Contents

Annotations

Notes

References

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