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HUMAN:UFM1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | UFM1 (synonyms: C13orf20) | |
| Protein Name(s) | Ubiquitin-fold modifier 1 | |
| External Links | ||
| UniProt | P61960 | |
| EMBL | AB154404 AF208844 CR457189 DA664581 AL356863 AL356863 BC005193 Z70222 | |
| CCDS | CCDS66533.1 CCDS9366.1 | |
| RefSeq | NP_001273632.1 NP_001273633.1 NP_001273634.1 NP_001273635.1 NP_057701.1 | |
| UniGene | Hs.643655 | |
| PDB | 1WXS 5HKH 5IAA 5L95 | |
| PDBsum | 1WXS 5HKH 5IAA 5L95 | |
| ProteinModelPortal | P61960 | |
| SMR | P61960 | |
| BioGrid | 119616 | |
| IntAct | P61960 | |
| MINT | MINT-7005139 | |
| STRING | 9606.ENSP00000239878 | |
| iPTMnet | P61960 | |
| PhosphoSitePlus | P61960 | |
| DMDM | 48428799 | |
| EPD | P61960 | |
| MaxQB | P61960 | |
| PaxDb | P61960 | |
| PeptideAtlas | P61960 | |
| PRIDE | P61960 | |
| TopDownProteomics | P61960-1 P61960-2 | |
| DNASU | 51569 | |
| Ensembl | ENST00000239878 ENST00000379649 | |
| GeneID | 51569 | |
| KEGG | hsa:51569 | |
| UCSC | uc001uwu.5 | |
| CTD | 51569 | |
| DisGeNET | 51569 | |
| GeneCards | UFM1 | |
| HGNC | HGNC:20597 | |
| HPA | HPA039758 | |
| MIM | 610553 | |
| neXtProt | NX_P61960 | |
| OpenTargets | ENSG00000120686 | |
| PharmGKB | PA134863405 | |
| eggNOG | KOG3483 ENOG4111TVI | |
| GeneTree | ENSGT00390000010391 | |
| HOGENOM | HOG000238677 | |
| HOVERGEN | HBG094129 | |
| InParanoid | P61960 | |
| KO | K12162 | |
| OMA | CACITND | |
| OrthoDB | EOG091G0DO7 | |
| PhylomeDB | P61960 | |
| TreeFam | TF312934 | |
| ChiTaRS | UFM1 | |
| EvolutionaryTrace | P61960 | |
| GeneWiki | UFM1 | |
| GenomeRNAi | 51569 | |
| PRO | PR:P61960 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000120686 | |
| CleanEx | HS_UFM1 | |
| ExpressionAtlas | P61960 | |
| Genevisible | P61960 | |
| GO | GO:0005737 GO:0005783 GO:0070062 GO:0005634 GO:0043066 GO:1990592 GO:0071569 GO:0033146 GO:0034976 | |
| CDD | cd01766 | |
| InterPro | IPR029071 IPR005375 | |
| PANTHER | PTHR15825 | |
| Pfam | PF03671 | |
| PIRSF | PIRSF038027 | |
| SUPFAM | SSF54236 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
HUMAN UFM1 (Ufm1) // Immunofluorescence assay revealed that endogenous Ufm1 was highly expressed in the HUVECs and was localized in the nucleus (Fig. 1A-C). |
complete | ||||
| GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
HUMAN UFM1 (Ufm1) // Immunofluorescence assay revealed that endogenous Ufm1 was highly expressed in the HUVECs and was localized in the cytoplasm. Arrows indicate the expression of Ufm1 in the cytoplasm (Fig. 1C). |
complete | ||||
| GO:0042308 |
negative regulation of protein import into nucleus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
HUMAN UFM1 (Ufm1) // Overexpression of Ufm1 lead to a decrease in translocation of NF-κB into the nucleus. Ufm1 overexpression reversed the role of LPS, resulting in decreased expression of NF-κB in the nucleus (Fig. 5A-C). |
complete | ||||
|
involved_in |
GO:0071569 |
protein ufmylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007420 |
brain development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1990592 |
protein K69-linked ufmylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033146 |
regulation of intracellular estrogen receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071569 |
protein ufmylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1990592 |
protein K69-linked ufmylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000406181 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1915140 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1915140 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034976 |
response to endoplasmic reticulum stress |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071569 |
protein ufmylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P61961 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034976 |
response to endoplasmic reticulum stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P61961 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P61961 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P61961 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P61961 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5BJP3 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Li, YY et al. (2017) Ufm1 inhibits LPS-induced endothelial cell inflammatory responses through the NF-κB signaling pathway. Int. J. Mol. Med. 39 1119-1126 PubMed GONUTS page
- ↑ 2.0 2.1 Nahorski, MS et al. (2018) Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development. Brain 141 1934-1945 PubMed GONUTS page
- ↑ 3.0 3.1 Yoo, HM et al. (2014) Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development. Mol. Cell 56 261-74 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Komatsu, M et al. (2004) A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. EMBO J. 23 1977-86 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Zhang, Y et al. (2012) Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking. PLoS ONE 7 e48587 PubMed GONUTS page
