HUMAN:UCP4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SLC25A27 (synonyms: UCP4)
Protein Name(s)	Mitochondrial uncoupling protein 4 UCP 4 Solute carrier family 25 member 27
External Links
UniProt	O95847
EMBL	AF110532 AY358711 AK291427 AL591242 CH471081 BC033091
CCDS	CCDS43470.1 CCDS56431.1
RefSeq	NP_001190980.1 NP_001190981.1 NP_004268.3
UniGene	Hs.40510
ProteinModelPortal	O95847
SMR	O95847
IntAct	O95847
STRING	9606.ENSP00000360398
TCDB	2.A.29.24.3
PaxDb	O95847
PRIDE	O95847
DNASU	9481
Ensembl	ENST00000371347 ENST00000411689
GeneID	9481
KEGG	hsa:9481
UCSC	uc003oyh.3
CTD	9481
GeneCards	GC06P046620
HGNC	HGNC:21065
HPA	CAB009508
MIM	613725
neXtProt	NX_O95847
PharmGKB	PA134970102
eggNOG	NOG240642
GeneTree	ENSGT00760000119170
HOGENOM	HOG000165140
HOVERGEN	HBG009528
InParanoid	O95847
KO	K15112
OMA	RMTPWSL
OrthoDB	EOG7MSMPK
PhylomeDB	O95847
TreeFam	TF354328
GeneWiki	SLC25A27
GenomeRNAi	9481
NextBio	35536
PRO	PR:O95847
Proteomes	UP000005640
Bgee	O95847
CleanEx	HS_SLC25A27
ExpressionAtlas	O95847
Genevestigator	O95847
GO	GO:0045177 GO:0016021 GO:0005743 GO:0005739 GO:0043025 GO:0035356 GO:0006091 GO:0048839 GO:0043066 GO:0051562 GO:0010917 GO:0070997 GO:0008284 GO:0046324 GO:0006810
Gene3D	1.50.40.10
InterPro	IPR018108 IPR023395
Pfam	PF00153
SUPFAM	SSF103506
PROSITE	PS50920

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0031966	mitochondrial membrane	PMID:10025957	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:10025957	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009409	response to cold		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001942541 WB:WBGene00006729	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070997	neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R5J6 ensembl:ENSRNOP00000039207	P		Seeded From UniProt	complete
involved_in	GO:0051562	negative regulation of mitochondrial calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R5J6 ensembl:ENSRNOP00000039207	P		Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R5J6 ensembl:ENSRNOP00000039207	P		Seeded From UniProt	complete
involved_in	GO:0046324	regulation of glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R5J6 ensembl:ENSRNOP00000039207	P		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R5J6 ensembl:ENSRNOP00000039207	C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R5J6 ensembl:ENSRNOP00000039207	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R5J6 ensembl:ENSRNOP00000039207	C		Seeded From UniProt	complete
involved_in	GO:0035356	cellular triglyceride homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R5J6 ensembl:ENSRNOP00000039207	P		Seeded From UniProt	complete
involved_in	GO:0010917	negative regulation of mitochondrial membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R5J6 ensembl:ENSRNOP00000039207	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R5J6 ensembl:ENSRNOP00000039207	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R5J6 ensembl:ENSRNOP00000039207	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9D6D0 ensembl:ENSMUSP00000024705	C		Seeded From UniProt	complete
enables	GO:0022857	transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040062	F		Seeded From UniProt	complete
involved_in	GO:1902600	proton transmembrane transport	Reactome:R-HSA-167827 Reactome:R-HSA-166187	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	Reactome:R-HSA-170026 Reactome:R-HSA-166387 Reactome:R-HSA-166220 Reactome:R-HSA-166214	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0999 UniProtKB-SubCell:SL-0168	C		Seeded From UniProt	complete
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References

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