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PMID:10025957

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Citation

Mao, W, Yu, XX, Zhong, A, Li, W, Brush, J, Sherwood, SW, Adams, SH and Pan, G (1999) UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett. 443:326-30

Abstract

Uncoupling proteins (UCPs) are a family of mitochondrial transporter proteins that have been implicated in thermoregulatory heat production and maintenance of the basal metabolic rate. We have identified and partially characterized a novel member of the human uncoupling protein family, termed uncoupling protein-4 (UCP4). Protein sequence analyses showed that UCP4 is most related to UCP3 and possesses features characteristic of mitochondrial transporter proteins. Unlike other known UCPs, UCP4 transcripts are exclusively expressed in both fetal and adult brain tissues. UCP4 maps to human chromosome 6p11.2-q12. Consistent with its potential role as an uncoupling protein, UCP4 is localized to the mitochondria and its ectopic expression in mammalian cells reduces mitochondrial membrane potential. These findings suggest that UCP4 may be involved in thermoregulatory heat production and metabolism in the brain.

Links

PubMed

Keywords

Amino Acid Sequence; Animals; Brain/embryology; Brain/metabolism; Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology; Carrier Proteins/analysis; Carrier Proteins/chemistry; Carrier Proteins/genetics; Carrier Proteins/physiology; Cell Line; Cell Survival; Chromosome Mapping; Chromosomes, Human, Pair 6/genetics; Cloning, Molecular; Expressed Sequence Tags; Genes, Plant/genetics; Humans; Ion Channels; Membrane Potentials/drug effects; Membrane Transport Proteins; Mitochondria/metabolism; Mitochondria/physiology; Mitochondrial Proteins; Molecular Sequence Data; Organ Specificity; RNA, Messenger/analysis; Sequence Homology, Amino Acid; Transfection; Tumor Cells, Cultured

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:UCP4

located_in

GO:0031966: mitochondrial membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:UCP4

located_in

GO:0005739: mitochondrion

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:UCP4

part_of

GO:0005739: mitochondrion

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:UCP4

part_of

GO:0031966: mitochondrial membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

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