HUMAN:UBP15

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	USP15 (synonyms: KIAA0529)
Protein Name(s)	Ubiquitin carboxyl-terminal hydrolase 15 Deubiquitinating enzyme 15 Ubiquitin thioesterase 15 Ubiquitin-specific-processing protease 15 Unph-2 Unph4
External Links
UniProt	Q9Y4E8
EMBL	AF106069 AB011101 AF153604 AK023703 AK292337 AC048342 AC079035 AC117370 BC020688 BC063454 BC125123 AF013990
CCDS	CCDS58250.1 CCDS58251.1 CCDS8963.1
RefSeq	NP_001239007.1 NP_001239008.1 NP_006304.1
UniGene	Hs.434951
PDB	1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P
PDBsum	1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P
ProteinModelPortal	Q9Y4E8
SMR	Q9Y4E8
BioGrid	115283
DIP	DIP-50239N
IntAct	Q9Y4E8
MINT	MINT-4542165
STRING	9606.ENSP00000258123
MEROPS	C19.022
PhosphoSite	Q9Y4E8
BioMuta	USP15
DMDM	28381406
MaxQB	Q9Y4E8
PaxDb	Q9Y4E8
PRIDE	Q9Y4E8
DNASU	9958
Ensembl	ENST00000280377 ENST00000312635 ENST00000353364
GeneID	9958
KEGG	hsa:9958
UCSC	uc001sra.3 uc001srb.2 uc001src.2
CTD	9958
GeneCards	USP15
H-InvDB	HIX0010773
HGNC	HGNC:12613
HPA	HPA006237
MIM	604731
neXtProt	NX_Q9Y4E8
PharmGKB	PA37239
eggNOG	COG5560
GeneTree	ENSGT00670000097750
HOGENOM	HOG000264375
HOVERGEN	HBG000864
InParanoid	Q9Y4E8
KO	K11835
OMA	IYVFEIA
OrthoDB	EOG77Q4VW
PhylomeDB	Q9Y4E8
TreeFam	TF106276
Reactome	R-HSA-2173788
ChiTaRS	USP15
EvolutionaryTrace	Q9Y4E8
GeneWiki	USP15
GenomeRNAi	9958
NextBio	37576
PRO	PR:Q9Y4E8
Proteomes	UP000005640
Bgee	Q9Y4E8
CleanEx	HS_USP15
ExpressionAtlas	Q9Y4E8
Genevisible	Q9Y4E8
GO	GO:0005737 GO:0005634 GO:0004197 GO:0042802 GO:0046332 GO:0005160 GO:0004843 GO:0061649 GO:0030509 GO:0035616 GO:0035520 GO:0030512 GO:0060389 GO:0043161 GO:0016579 GO:0061136 GO:0007179
Gene3D	3.30.2230.10
InterPro	IPR006615 IPR001394 IPR013792 IPR028135 IPR029071 IPR029346 IPR018200 IPR028889
Pfam	PF06337 PF14836 PF00443 PF14533
SMART	SM00695
SUPFAM	SSF143791 SSF54236 SSF55205
PROSITE	PS51283 PS00972 PS00973 PS50235

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0035520	monoubiquitinated protein deubiquitination	PMID:24399297^[1]	ECO:0000314			P	Figure 2	complete CACAO 11179
	GO:0016579	protein deubiquitination	PMID:24399297^[1]	ECO:0000314			P	Figure 2	complete CACAO 11180
	GO:1990380	Lys48-specific deubiquitinase activity	PMID:24399297^[1]	ECO:0000314			F	Fig. 1A	complete CACAO 11183
	GO:0031397	negative regulation of protein ubiquitination	PMID:24399297^[1]	ECO:0000315			P	Figure 3	complete CACAO 11184
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:27368102^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
	GO:1900246	positive regulation of RIG-I signaling pathway	PMID:24399297^[1]	ECO:0000314			P	Figure 4	complete CACAO 11185
involved_in	GO:0016579	protein deubiquitination	PMID:27368102^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24526689^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0061649	ubiquitin modification-dependent histone binding	PMID:24526689^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24526689^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:24526689^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0035616	histone H2B conserved C-terminal lysine deubiquitination	PMID:24526689^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	PMID:22344298^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:22344298^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15105	F	Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21947082^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P84022	F	Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21947082^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15796	F	Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21947082^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15797	F	Seeded From UniProt	complete
involved_in	GO:0035520	monoubiquitinated protein deubiquitination	PMID:21947082^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:21947082^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	PMID:22344298^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	PMID:16005295^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:22344298^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21947082^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21947082^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21947082^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:22344298^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P36897	F	Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:22344298^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:21947082^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:16005295^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	PMID:21947082^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:22344298^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:21947082^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001162727 RGD:628795 UniProtKB:Q9Y4E8	C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22001210^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y4E8	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R5H1 ensembl:ENSMUSP00000151244	F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013792	F	Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006615	F	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018200	P	Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001394 InterPro:IPR028134	P	Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001394 InterPro:IPR018200	F	Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.4.19.12	F	Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:10444327^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:9827704^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	Reactome:R-HSA-6781764	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-6781764	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F	Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Pauli, EK et al. (2014) The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25. Sci Signal 7 ra3 PubMed GONUTS page
↑ ^2.0 ^2.1 Jongsma, ML et al. (2016) An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport. Cell 166 152-66 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Long, L et al. (2014) The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination. J. Biol. Chem. 289 8916-30 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Eichhorn, PJ et al. (2012) USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma. Nat. Med. 18 429-35 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 Inui, M et al. (2011) USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat. Cell Biol. 13 1368-75 PubMed GONUTS page
↑ ^6.0 ^6.1 Hetfeld, BK et al. (2005) The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1. Curr. Biol. 15 1217-21 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Elliott, PR et al. (2011) Structural variability of the ubiquitin specific protease DUSP-UBL double domains. FEBS Lett. 585 3385-90 PubMed GONUTS page
↑ Baker, RT et al. (1999) Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. Genomics 59 264-74 PubMed GONUTS page
↑ D'Andrea, A & Pellman, D (1998) Deubiquitinating enzymes: a new class of biological regulators. Crit. Rev. Biochem. Mol. Biol. 33 337-52 PubMed GONUTS page

[PMID:24399297-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Pauli, EK et al. (2014) The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25. Sci Signal 7 ra3 PubMed GONUTS page

[PMID:27368102-2] 2.0 ^2.1 Jongsma, ML et al. (2016) An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport. Cell 166 152-66 PubMed GONUTS page

[PMID:24526689-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Long, L et al. (2014) The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination. J. Biol. Chem. 289 8916-30 PubMed GONUTS page

[PMID:22344298-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Eichhorn, PJ et al. (2012) USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma. Nat. Med. 18 429-35 PubMed GONUTS page

[PMID:21947082-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 Inui, M et al. (2011) USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat. Cell Biol. 13 1368-75 PubMed GONUTS page

[PMID:16005295-6] 6.0 ^6.1 Hetfeld, BK et al. (2005) The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1. Curr. Biol. 15 1217-21 PubMed GONUTS page

[PMID:21873635-7] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22001210-8] Elliott, PR et al. (2011) Structural variability of the ubiquitin specific protease DUSP-UBL double domains. FEBS Lett. 585 3385-90 PubMed GONUTS page

[PMID:10444327-9] Baker, RT et al. (1999) Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. Genomics 59 264-74 PubMed GONUTS page

[PMID:9827704-10] D'Andrea, A & Pellman, D (1998) Deubiquitinating enzymes: a new class of biological regulators. Crit. Rev. Biochem. Mol. Biol. 33 337-52 PubMed GONUTS page

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HUMAN:UBP15

Contents

Annotations

Notes

References

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