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HUMAN:TWST2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TWIST2 (synonyms: BHLHA39, DERMO1)
Protein Name(s) Twist-related protein 2

Class A basic helix-loop-helix protein 39 bHLHa39 Dermis-expressed protein 1 Dermo-1

External Links
UniProt Q8WVJ9
EMBL BC017907
BC033168
BC103755
CCDS CCDS46558.1
RefSeq NP_001258822.1
NP_476527.1
XP_006712305.1
UniGene Hs.422585
Hs.745035
ProteinModelPortal Q8WVJ9
SMR Q8WVJ9
BioGrid 125591
IntAct Q8WVJ9
PhosphoSite Q8WVJ9
DMDM 32699724
PaxDb Q8WVJ9
PRIDE Q8WVJ9
DNASU 117581
GeneID 117581
KEGG hsa:117581
UCSC uc010znx.2
CTD 117581
GeneCards GC02P239757
HGNC HGNC:20670
MIM 227260
607556
neXtProt NX_Q8WVJ9
Orphanet 1807
PharmGKB PA134973713
eggNOG NOG258515
GeneTree ENSGT00760000119097
HOGENOM HOG000261629
HOVERGEN HBG019071
InParanoid Q8WVJ9
KO K09069
OMA DNKMSSC
OrthoDB EOG7TJ3M9
PhylomeDB Q8WVJ9
TreeFam TF315153
GeneWiki TWIST2
GenomeRNAi 117581
NextBio 80218
PRO PR:Q8WVJ9
Proteomes UP000005640
Bgee Q8WVJ9
CleanEx HS_TWIST2
ExpressionAtlas Q8WVJ9
Genevestigator Q8WVJ9
GO GO:0005737
GO:0005634
GO:0003677
GO:0030154
GO:0007275
GO:0045668
GO:0045892
GO:0006351
Gene3D 4.10.280.10
InterPro IPR011598
Pfam PF00010
SMART SM00353
SUPFAM SSF47459
PROSITE PS50888

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0030335

positive regulation of cell migration

PMID:24171926[1]

ECO:0000316

genetic interaction evidence used in manual assertion

RNAcentral:URS000040780F_9606

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9D030

P

Seeded From UniProt

complete

involved_in

GO:0045668

negative regulation of osteoblast differentiation

PMID:11062344[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11062344[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11062344[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97831
ensembl:ENSRNOP00000027597

P

Seeded From UniProt

complete

enables

GO:0046983

protein dimerization activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011598
InterPro:IPR036638

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Long, L et al. (2013) Down-regulation of miR-138 promotes colorectal cancer metastasis via directly targeting TWIST2. J Transl Med 11 275 PubMed GONUTS page
  2. 2.0 2.1 2.2 Lee, MS et al. (2000) Human Dermo-1 has attributes similar to twist in early bone development. Bone 27 591-602 PubMed GONUTS page