HUMAN:TTBK2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TTBK2 (synonyms: KIAA0847)
Protein Name(s)	Tau-tubulin kinase 2
External Links
UniProt	Q6IQ55
EMBL	AK131372 AC068727 AC090510 BC041876 BC071556 AB020654
CCDS	CCDS42029.1
RefSeq	NP_775771.3
UniGene	Hs.646511 Hs.727864 Hs.733489
ProteinModelPortal	Q6IQ55
SMR	Q6IQ55
BioGrid	126962
IntAct	Q6IQ55
STRING	9606.ENSP00000267890
PhosphoSite	Q6IQ55
DMDM	116242833
MaxQB	Q6IQ55
PaxDb	Q6IQ55
PRIDE	Q6IQ55
Ensembl	ENST00000267890 ENST00000567840
GeneID	146057
KEGG	hsa:146057
UCSC	uc001zqo.2 uc001zqp.3
CTD	146057
GeneCards	GC15M043030
GeneReviews	TTBK2
H-InvDB	HIX0012177
HGNC	HGNC:19141
HPA	HPA018113
MIM	604432 611695
neXtProt	NX_Q6IQ55
Orphanet	98767
PharmGKB	PA134913925
eggNOG	COG0515
GeneTree	ENSGT00760000119040
HOGENOM	HOG000232043
HOVERGEN	HBG061812
InParanoid	Q6IQ55
KO	K08815
OMA	HCKPSKN
OrthoDB	EOG7RFTGM
PhylomeDB	Q6IQ55
TreeFam	TF351646
SignaLink	Q6IQ55
GeneWiki	TTBK2
GenomeRNAi	146057
NextBio	85251
PRO	PR:Q6IQ55
Proteomes	UP000005640
Bgee	Q6IQ55
CleanEx	HS_TTBK2
ExpressionAtlas	Q6IQ55
Genevestigator	Q6IQ55
GO	GO:0005814 GO:0036064 GO:0035869 GO:0005829 GO:0005615 GO:0005634 GO:0005524 GO:0004674 GO:0042384 GO:0018105 GO:0007224
InterPro	IPR011009 IPR000719 IPR017441
Pfam	PF00069
SUPFAM	SSF56112
PROSITE	PS00107 PS50011

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004672	protein kinase activity	PMID:21548880^[1]	ECO:0000314			F		Figure 4. Cells expressing GFP-TTBK2 were treated to induce the expression of TTBK2. Flourcent imaging was performed using a confocal microscope. Mutations showed an increase in TTBK2 as well as protein kinase activity.	complete CACAO 9373
enables	GO:0019894	kinesin binding	PMID:26323690^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9WV63	F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:28386764^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:1904527	negative regulation of microtubule binding	PMID:26323690^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O00139)	Seeded From UniProt	complete
involved_in	GO:0007026	negative regulation of microtubule depolymerization	PMID:26323690^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:26323690^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:O00139) negatively_regulates:(GO:0007019) negatively_regulates:(GO:0008017) occurs_at:(GO:0005874)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:26323690^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:O00139)	Seeded From UniProt	complete
involved_in	GO:0021935	cerebellar granule cell precursor tangential migration	PMID:26323690^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3UVR3	P	part_of:(GO:0021681) part_of:(GO:0021549)	Seeded From UniProt	complete
involved_in	GO:0021681	cerebellar granular layer development	PMID:26323690^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3UVR3	P		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	PMID:26323690^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3UVR3	P		Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	PMID:26323690^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O00139	P		Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	PMID:26323690^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O00139	P	regulates:(GO:0016477)	Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:28386764^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:28386764^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902817	negative regulation of protein localization to microtubule	PMID:26323690^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O00139)	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:23141541^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:23141541^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0035869	ciliary transition zone	PMID:23141541^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002586)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:22664934^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3UVR3	P		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3UVR3	C		Seeded From UniProt	complete
part_of	GO:0035869	ciliary transition zone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3UVR3	C		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21548880^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3UVR3	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21548880^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21548880^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21548880^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2155779 PANTHER:PTN002628896 UniProtKB:Q6IQ55	P		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2155779 PANTHER:PTN002628896	C		Seeded From UniProt	complete
part_of	GO:0035869	ciliary transition zone	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2155779 PANTHER:PTN002628896 UniProtKB:Q6IQ55	C		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0027889 PANTHER:PTN002628885 SGD:S000002175 UniProtKB:Q5TCY1	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2155779 PANTHER:PTN002628885 RGD:71098 SGD:S000002175 UniProtKB:P35507 UniProtKB:P35508 UniProtKB:P48729 UniProtKB:P48730 UniProtKB:P49674 UniProtKB:P67827 UniProtKB:P78368 UniProtKB:Q5TCY1 UniProtKB:Q6IQ55 UniProtKB:Q9HCP0 UniProtKB:Q9Y6M4 ZFIN:ZDB-GENE-020419-19	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002413 FB:FBgn0015024 FB:FBgn0030384 FB:FBgn0031441 FB:FBgn0032650 FB:FBgn0037325 FB:FBgn0039908 PANTHER:PTN000225966 PomBase:SPBP35G2.05c RGD:62045 RGD:71098 TAIR:locus:2018269 TAIR:locus:2024147 TAIR:locus:2030170 TAIR:locus:2117778 TAIR:locus:2117843 TAIR:locus:2129640 TAIR:locus:504954933 UniProtKB:C8V7X8 UniProtKB:O00311 UniProtKB:P49674 UniProtKB:Q86Y07 WB:WBGene00002202 WB:WBGene00013709 dictyBase:DDB_G0273059	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002413 FB:FBgn0015024 FB:FBgn0027889 FB:FBgn0030384 MGI:MGI:1261847 MGI:MGI:1351660 MGI:MGI:1355272 MGI:MGI:2182465 PANTHER:PTN000225966 PomBase:SPBC776.12c RGD:62045 RGD:71098 SGD:S000000925 SGD:S000002175 SGD:S000006125 TAIR:locus:2024147 TAIR:locus:2030170 TAIR:locus:2117778 TAIR:locus:2117843 TAIR:locus:2129640 UniProtKB:A0A0B4KHL4 UniProtKB:C8V7X8 UniProtKB:C8VHB6 UniProtKB:O00311 UniProtKB:Q6IQ55 UniProtKB:Q6K9N1 UniProtKB:Q852L0 UniProtKB:Q86Y07 UniProtKB:Q8IV63 UniProtKB:Q99986 WB:WBGene00002202 WB:WBGene00017895 dictyBase:DDB_G0273059	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002413 FB:FBgn0015024 FB:FBgn0031441 FB:FBgn0032650 FB:FBgn0037325 MGI:MGI:1261847 MGI:MGI:1917172 MGI:MGI:2155779 PANTHER:PTN002628885 PomBase:SPAC23C4.12 PomBase:SPBC1347.06c PomBase:SPBC3H7.15 PomBase:SPBC776.12c RGD:62045 RGD:621404 RGD:621407 RGD:621408 RGD:71031 RGD:71098 SGD:S000001177 SGD:S000002175 SGD:S000005098 SGD:S000006125 TAIR:locus:2091566 TAIR:locus:2117843 TAIR:locus:2121338 TAIR:locus:2129640 TAIR:locus:2130290 UniProtKB:A0A0B4KHL4 UniProtKB:P35507 UniProtKB:P35508 UniProtKB:P48729 UniProtKB:P48730 UniProtKB:P49674 UniProtKB:P67827 UniProtKB:P78368 UniProtKB:Q6IQ55 UniProtKB:Q86Y07 UniProtKB:Q8IHZ9 UniProtKB:Q99986 UniProtKB:Q9HCP0 UniProtKB:Q9Y6M4 dictyBase:DDB_G0273059	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	P		Seeded From UniProt	complete
enables	GO:0051010	microtubule plus-end binding	PMID:26323690^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:26323690^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:0097711	ciliary basal body-plasma membrane docking	Reactome:R-HSA-5620912	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5638009 Reactome:R-HSA-5626699 Reactome:R-HSA-5626681 Reactome:R-HSA-5626228 Reactome:R-HSA-5626227 Reactome:R-HSA-5617816	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0970	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005814	centriole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0046	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Bouskila, M et al. (2011) TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. Biochem. J. 437 157-67 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Watanabe, T et al. (2015) TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation. J. Cell Biol. 210 737-51 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Goetz, SC et al. (2012) The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. Cell 151 847-858 PubMed GONUTS page
↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21548880-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Bouskila, M et al. (2011) TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. Biochem. J. 437 157-67 PubMed GONUTS page

[PMID:26323690-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Watanabe, T et al. (2015) TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation. J. Cell Biol. 210 737-51 PubMed GONUTS page

[PMID:28386764-3] 3.0 ^3.1 ^3.2 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page

[PMID:23141541-4] 4.0 ^4.1 ^4.2 Goetz, SC et al. (2012) The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. Cell 151 847-858 PubMed GONUTS page

[PMID:22664934-5] Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:TTBK2

Contents

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