HUMAN:TRPV4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TRPV4 (synonyms: VRL2, VROAC)
Protein Name(s)	Transient receptor potential cation channel subfamily V member 4 TrpV4 Osm-9-like TRP channel 4 OTRPC4 Transient receptor potential protein 12 TRP12 Vanilloid receptor-like channel 2 Vanilloid receptor-like protein 2 VRL-2 Vanilloid receptor-related osmotically-activated channel VR-OAC
External Links
UniProt	Q9HBA0
EMBL	AF263523 AF258465 AB100308 AB032427 AB073669 AJ296305 DQ059644 DQ059645 DQ059646 CH471054 BC117426 BC143315 AF279673
CCDS	CCDS53827.1 CCDS53828.1 CCDS53829.1 CCDS9134.1 CCDS9135.1
RefSeq	NP_001170899.1 NP_001170902.1 NP_001170904.1 NP_067638.3 NP_671737.1 XP_005253975.1 XP_005253976.1
UniGene	Hs.506713
PDB	4DX1 4DX2
PDBsum	4DX1 4DX2
ProteinModelPortal	Q9HBA0
SMR	Q9HBA0
BioGrid	121883
DIP	DIP-35702N
IntAct	Q9HBA0
MINT	MINT-4535111
BindingDB	Q9HBA0
ChEMBL	CHEMBL3119
GuidetoPHARMACOLOGY	510
PhosphoSite	Q9HBA0
DMDM	62901470
MaxQB	Q9HBA0
PaxDb	Q9HBA0
PRIDE	Q9HBA0
Ensembl	ENST00000261740 ENST00000418703 ENST00000536838 ENST00000537083 ENST00000541794 ENST00000544971
GeneID	59341
KEGG	hsa:59341
UCSC	uc001tpg.2 uc001tph.2 uc001tpi.2 uc001tpj.2 uc021rdp.1
CTD	59341
GeneCards	GC12M110220
GeneReviews	TRPV4
HGNC	HGNC:18083
HPA	HPA007150
MIM	113500 156530 168400 181405 184095 184252 600175 605427 606071 606835 613508
neXtProt	NX_Q9HBA0
Orphanet	93304 99937 1216 85169 2635 2646 263482 93314
PharmGKB	PA38293
eggNOG	NOG278734
GeneTree	ENSGT00550000074425
HOVERGEN	HBG054085
InParanoid	Q9HBA0
KO	K04973
OMA	NTLYFTR
OrthoDB	EOG70S74P
PhylomeDB	Q9HBA0
TreeFam	TF314711
Reactome	REACT_169333
SignaLink	Q9HBA0
GeneWiki	TRPV4
GenomeRNAi	59341
NextBio	65228
PRO	PR:Q9HBA0
Proteomes	UP000005640
Bgee	Q9HBA0
ExpressionAtlas	Q9HBA0
Genevestigator	Q9HBA0
GO	GO:0005912 GO:0009986 GO:0005929 GO:0030864 GO:0005881 GO:0031410 GO:0030175 GO:0005925 GO:0030426 GO:0016021 GO:0030027 GO:0005886 GO:0032587 GO:0003779 GO:0051015 GO:0043014 GO:0005524 GO:0048487 GO:0005262 GO:0005516 GO:0005261 GO:0008017 GO:0005034 GO:0019901 GO:0005080 GO:0042169 GO:0031532 GO:0007015 GO:0070509 GO:0070588 GO:0006816 GO:0006884 GO:0007043 GO:0006874 GO:0071476 GO:0034605 GO:0071470 GO:0043622 GO:0042538 GO:0034220 GO:0046785 GO:0010977 GO:0007231 GO:0007204 GO:0031117 GO:0047484 GO:0009612 GO:0055085 GO:0030103
Gene3D	1.25.40.20
InterPro	IPR002110 IPR020683 IPR005821 IPR004729 IPR008347 IPR008348
PANTHER	PTHR10582:SF4
Pfam	PF00023 PF00520
PRINTS	PR01768 PR01769
SMART	SM00248
SUPFAM	SSF48403
TIGRFAMs	TIGR00870
PROSITE	PS50297 PS50088

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0031513	cilium	PMID:18024594^[1]	ECO:0000314			C		Figure 2: They found that TRPV4 is expressed in cholangiocyte cilia	complete
involved_in	GO:0060351	cartilage development involved in endochondral bone morphogenesis	PMID:26249260^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	PMID:23136043^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043117	positive regulation of vascular permeability	PMID:23136043^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097497	blood vessel endothelial cell delamination	PMID:23136043^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0007777)	Seeded From UniProt	complete
enables	GO:0015275	stretch-activated, cation-selective, calcium channel activity	PMID:23136043^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0071476	cellular hypotonic response	PMID:23136043^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050891	multicellular organismal water homeostasis	PMID:23136043^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:23136043^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001567) part_of:(CL:1000223) part_of:(CL:0000082) part_of:(UBERON:0004297) part_of:(CL:0000583)	Seeded From UniProt	complete
involved_in	GO:0071476	cellular hypotonic response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EPK8	P		Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	P		Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EPK8	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	F		Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	F		Seeded From UniProt	complete
involved_in	GO:0046785	microtubule polymerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	P		Seeded From UniProt	complete
involved_in	GO:0043622	cortical microtubule organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	P		Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	F		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EPK8	F		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	C		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	P		Seeded From UniProt	complete
involved_in	GO:0031117	positive regulation of microtubule depolymerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	P		Seeded From UniProt	complete
part_of	GO:0030864	cortical actin cytoskeleton	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	C		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:12538589^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:12538589^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07947	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:12538589^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07948	F		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	F		Seeded From UniProt	complete
involved_in	GO:0007231	osmosensory signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EPK8	P		Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	C		Seeded From UniProt	complete
colocalizes_with	GO:0005881	cytoplasmic microtubule	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	C		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ERZ8	F		Seeded From UniProt	complete
involved_in	GO:0071470	cellular response to osmotic stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EPK8	P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EPK8	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:11025659^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:18458941^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007043	cell-cell junction assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EPK8	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:12724311^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:18458941^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:11025659^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EPK8	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15753126^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EPK8	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:12724311^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:18458941^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	PMID:12724311^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071476	cellular hypotonic response	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926945 PANTHER:PTN000061708 UniProtKB:F1RIT1 UniProtKB:Q9HBA0	P		Seeded From UniProt	complete
involved_in	GO:0007231	osmosensory signaling pathway	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926945 PANTHER:PTN000061708	P		Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000061708 RGD:69337 UniProtKB:F1RIT1	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926945 PANTHER:PTN000061708 UniProtKB:Q9HBA0	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926945 PANTHER:PTN000061708 UniProtKB:F1RIT1	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000061616 RGD:628841 RGD:69335 UniProtKB:Q9H1D0 UniProtKB:Q9NQA5	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341787 MGI:MGI:1341836 MGI:MGI:1926945 MGI:MGI:1927259 MGI:MGI:2429764 PANTHER:PTN000832860 RGD:620636 RGD:69335 RGD:69337 SGD:S000005613 UniProtKB:F1RIT1 UniProtKB:Q9H1D0 UniProtKB:Q9HBA0 UniProtKB:Q9NQA5 WB:WBGene00003889	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341787 MGI:MGI:2181407 PANTHER:PTN000061616	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26146187^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HBA0	F		Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:1903759	signal transduction involved in regulation of aerobic respiration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:1903444	negative regulation of brown fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0071642	positive regulation of macrophage inflammatory protein 1 alpha production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0071477	cellular hypotonic salinity response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0071476	cellular hypotonic response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0071470	cellular response to osmotic stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0047484	regulation of response to osmotic stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0043117	positive regulation of vascular permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0042538	hyperosmotic salinity response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	F		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0030103	vasopressin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	F		Seeded From UniProt	complete
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0007231	osmosensory signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0007043	cell-cell junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0006970	response to osmotic stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	F		Seeded From UniProt	complete
enables	GO:0005034	osmosensor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	F		Seeded From UniProt	complete
involved_in	GO:0002024	diet induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK8 ensembl:ENSMUSP00000071859	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
involved_in	GO:0050891	multicellular organismal water homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
involved_in	GO:0046785	microtubule polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
involved_in	GO:0043622	cortical microtubule organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
involved_in	GO:0043117	positive regulation of vascular permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
involved_in	GO:0031117	positive regulation of microtubule depolymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
part_of	GO:0030864	cortical actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
involved_in	GO:0006971	hypotonic response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
part_of	GO:0005881	cytoplasmic microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821 InterPro:IPR008347 InterPro:IPR008348 InterPro:IPR024862	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821 InterPro:IPR008347 InterPro:IPR008348 InterPro:IPR024862	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008347 InterPro:IPR008348 InterPro:IPR024862	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	PMID:15753126^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007231	osmosensory signaling pathway	PMID:12724311^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006884	cell volume homeostasis	PMID:12724311^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	Reactome:R-HSA-3295583	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-3295579	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0009	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gradilone, SA et al. (2007) Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion. Proc. Natl. Acad. Sci. U.S.A. 104 19138-43 PubMed GONUTS page
↑ Hurd, L et al. (2015) A mutation in TRPV4 results in altered chondrocyte calcium signaling in severe metatropic dysplasia. Am. J. Med. Genet. A 167A 2286-93 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Thorneloe, KS et al. (2012) An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. Sci Transl Med 4 159ra148 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Xu, H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J. Biol. Chem. 278 11520-7 PubMed GONUTS page
↑ ^5.0 ^5.1 Strotmann, R et al. (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat. Cell Biol. 2 695-702 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Fernández-Fernández, JM et al. (2008) Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines. Pflugers Arch. 457 149-59 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Strotmann, R et al. (2003) Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site. J. Biol. Chem. 278 26541-9 PubMed GONUTS page
↑ ^8.0 ^8.1 Andrade, YN et al. (2005) TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J. Cell Biol. 168 869-74 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Garcia-Elias, A et al. (2015) Interaction between the Linker, Pre-S1, and TRP Domains Determines Folding, Assembly, and Trafficking of TRPV Channels. Structure 23 1404-1413 PubMed GONUTS page

[PMID:18024594-1] Gradilone, SA et al. (2007) Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion. Proc. Natl. Acad. Sci. U.S.A. 104 19138-43 PubMed GONUTS page

[PMID:26249260-2] Hurd, L et al. (2015) A mutation in TRPV4 results in altered chondrocyte calcium signaling in severe metatropic dysplasia. Am. J. Med. Genet. A 167A 2286-93 PubMed GONUTS page

[PMID:23136043-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Thorneloe, KS et al. (2012) An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. Sci Transl Med 4 159ra148 PubMed GONUTS page

[PMID:12538589-4] 4.0 ^4.1 ^4.2 Xu, H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J. Biol. Chem. 278 11520-7 PubMed GONUTS page

[PMID:11025659-5] 5.0 ^5.1 Strotmann, R et al. (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat. Cell Biol. 2 695-702 PubMed GONUTS page

[PMID:18458941-6] 6.0 ^6.1 ^6.2 Fernández-Fernández, JM et al. (2008) Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines. Pflugers Arch. 457 149-59 PubMed GONUTS page

[PMID:12724311-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Strotmann, R et al. (2003) Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site. J. Biol. Chem. 278 26541-9 PubMed GONUTS page

[PMID:15753126-8] 8.0 ^8.1 Andrade, YN et al. (2005) TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J. Cell Biol. 168 869-74 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26146187-10] Garcia-Elias, A et al. (2015) Interaction between the Linker, Pre-S1, and TRP Domains Determines Folding, Assembly, and Trafficking of TRPV Channels. Structure 23 1404-1413 PubMed GONUTS page

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