GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:TRI62
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TRIM62 | |
| Protein Name(s) | E3 ubiquitin-protein ligase TRIM62
Tripartite motif-containing protein 62 | |
| External Links | ||
| UniProt | Q9BVG3 | |
| EMBL | AK001621 AK122896 AK300177 AL662907 CH471059 CH471059 BC001222 BC007999 BC011689 BC012152 | |
| CCDS | CCDS376.1 | |
| RefSeq | NP_060677.2 | |
| UniGene | Hs.656006 | |
| ProteinModelPortal | Q9BVG3 | |
| SMR | Q9BVG3 | |
| BioGrid | 120518 | |
| IntAct | Q9BVG3 | |
| MINT | MINT-1181483 | |
| PhosphoSite | Q9BVG3 | |
| DMDM | 74752380 | |
| PaxDb | Q9BVG3 | |
| PRIDE | Q9BVG3 | |
| Ensembl | ENST00000291416 ENST00000543586 | |
| GeneID | 55223 | |
| KEGG | hsa:55223 | |
| UCSC | uc001bxb.3 | |
| CTD | 55223 | |
| GeneCards | GC01M033611 | |
| HGNC | HGNC:25574 | |
| neXtProt | NX_Q9BVG3 | |
| PharmGKB | PA134890243 | |
| eggNOG | NOG303062 | |
| GeneTree | ENSGT00760000118838 | |
| HOGENOM | HOG000234133 | |
| HOVERGEN | HBG103330 | |
| InParanoid | Q9BVG3 | |
| KO | K12030 | |
| OMA | FCDEPAV | |
| OrthoDB | EOG7M98FZ | |
| PhylomeDB | Q9BVG3 | |
| TreeFam | TF342569 | |
| UniPathway | UPA00143 | |
| GenomeRNAi | 55223 | |
| NextBio | 35474911 | |
| PRO | PR:Q9BVG3 | |
| Proteomes | UP000005640 | |
| Bgee | Q9BVG3 | |
| CleanEx | HS_TRIM62 | |
| ExpressionAtlas | Q9BVG3 | |
| Genevestigator | Q9BVG3 | |
| GO | GO:0005737 GO:0016874 GO:0008270 GO:0045087 GO:0032897 GO:0043123 GO:0051092 GO:0051091 GO:0016567 GO:0046596 GO:1902186 | |
| Gene3D | 3.30.40.10 4.10.45.10 | |
| InterPro | IPR001870 IPR003879 IPR013320 IPR006574 IPR003877 IPR000315 IPR001841 IPR013083 IPR017907 | |
| Pfam | PF13765 PF00622 PF00643 | |
| PRINTS | PR01407 | |
| SMART | SM00589 SM00184 | |
| SUPFAM | SSF49899 | |
| PROSITE | PS50188 PS50119 PS00518 PS50089 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005737 |
cytoplasm |
ECO:0000314 |
C |
Figure 4. |
complete | |||||
| GO:0004842 |
ubiquitin-protein ligase activity |
ECO:0000314 |
F |
Figure 1A. |
complete | |||||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902186 |
regulation of viral release from host cell |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P05412) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046596 |
regulation of viral entry into host cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032897 |
negative regulation of viral transcription |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010719 |
negative regulation of epithelial to mesenchymal transition |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q80V85 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060333 |
interferon-gamma-mediated signaling pathway |
Reactome:R-HSA-877300 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-1031716 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Huang, F et al. (2013) Characterization of TRIM62 as a RING finger E3 ubiquitin ligase and its subcellular localization. Biochem. Biophys. Res. Commun. 432 208-13 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Uchil, PD et al. (2008) TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. PLoS Pathog. 4 e16 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Uchil, PD et al. (2013) TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. J. Virol. 87 257-72 PubMed GONUTS page
n
p
