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HUMAN:TPPP

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TPPP (synonyms: TPPP1)
Protein Name(s) Tubulin polymerization-promoting protein

TPPP 25 kDa brain-specific protein TPPP/p25 p24 p25-alpha

External Links
UniProt O94811
EMBL AB017016
BT020035
BC040496
CCDS CCDS3856.1
RefSeq NP_008961.1
UniGene Hs.481466
ProteinModelPortal O94811
SMR O94811
BioGrid 116259
IntAct O94811
MINT MINT-2798227
STRING 9606.ENSP00000353785
BindingDB O94811
PhosphoSite O94811
UCD-2DPAGE O94811
MaxQB O94811
PaxDb O94811
PRIDE O94811
Ensembl ENST00000360578
GeneID 11076
KEGG hsa:11076
UCSC uc003jbg.4
CTD 11076
GeneCards GC05M000659
HGNC HGNC:24164
HPA HPA036575
HPA036576
MIM 608773
neXtProt NX_O94811
PharmGKB PA162406809
eggNOG NOG271804
HOGENOM HOG000260314
HOVERGEN HBG036683
InParanoid O94811
OMA IHGDTRA
OrthoDB EOG7NGQDH
PhylomeDB O94811
TreeFam TF314440
GeneWiki TPPP
GenomeRNAi 11076
NextBio 42106
PRO PR:O94811
Proteomes UP000005640
Bgee O94811
CleanEx HS_TPPP
ExpressionAtlas O94811
Genevestigator O94811
GO GO:0005737
GO:0005874
GO:0005634
GO:0048471
GO:0008017
GO:0015631
GO:0001578
GO:0046785
GO:0031334
GO:0032273
InterPro IPR008907
PANTHER PTHR12932
Pfam PF05517

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0048714

regulation of oligodendrocyte differentiation

PMID:19606501[1]

ECO:0000314

P

Fig. 5A. More oligodendrocytes were differentiated when TPPP/p25 was increases

complete

colocalizes_with

GO:0097427

microtubule bundle

PMID:17105200[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:15590652[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0046785

microtubule polymerization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q27957

P

Seeded From UniProt

complete

involved_in

GO:0032273

positive regulation of protein polymerization

PMID:15590652[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031334

positive regulation of protein complex assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q27957

P

Seeded From UniProt

complete

enables

GO:0015631

tubulin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q27957

F

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q27957

F

Seeded From UniProt

complete

involved_in

GO:0001578

microtubule bundle formation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q27957

P

Seeded From UniProt

complete

involved_in

GO:0046785

microtubule polymerization

PMID:18028908[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0015631

tubulin binding

PMID:17105200[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

colocalizes_with

GO:0005874

microtubule

PMID:18028908[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:18028908[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18028908[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001578

microtubule bundle formation

PMID:17105200[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046785

microtubule polymerization

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0266417
MGI:MGI:1920198
PANTHER:PTN000309419
UniProtKB:O94811
UniProtKB:Q27957

P

Seeded From UniProt

complete

involved_in

GO:0032273

positive regulation of protein polymerization

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000309419
UniProtKB:O94811

P

Seeded From UniProt

complete

enables

GO:0015631

tubulin binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000309419
UniProtKB:O94811
UniProtKB:P59282
UniProtKB:Q27957
UniProtKB:Q9BW30

F

Seeded From UniProt

complete

colocalizes_with

GO:0005874

microtubule

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1920198
PANTHER:PTN000309419
UniProtKB:O94811

C

Seeded From UniProt

complete

involved_in

GO:0001578

microtubule bundle formation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0266417
PANTHER:PTN000309419
UniProtKB:O94811
UniProtKB:P59282
UniProtKB:Q27957
UniProtKB:Q9BW30

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0046785

microtubule polymerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TQD2
ensembl:ENSMUSP00000022057

P

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TQD2
ensembl:ENSMUSP00000022057

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TQD2
ensembl:ENSMUSP00000022057

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TQD2
ensembl:ENSMUSP00000022057

C

Seeded From UniProt

complete

involved_in

GO:0001578

microtubule bundle formation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030792

P

Seeded From UniProt

complete

enables

GO:0015631

tubulin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030792

F

Seeded From UniProt

complete

involved_in

GO:0046785

microtubule polymerization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030792

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Lehotzky, A et al. (2010) Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. Glia 58 157-68 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Vincze, O et al. (2006) Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. Biochemistry 45 13818-26 PubMed GONUTS page
  3. ↑ 3.0 3.1 Lindersson, E et al. (2005) p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. J. Biol. Chem. 280 5703-15 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Acevedo, K et al. (2007) The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules. Exp. Cell Res. 313 4091-106 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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