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HUMAN:TP4A3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PTP4A3 (synonyms: PRL3) | |
| Protein Name(s) | Protein tyrosine phosphatase type IVA 3
PRL-R Protein-tyrosine phosphatase 4a3 Protein-tyrosine phosphatase of regenerating liver 3 PRL-3 | |
| External Links | ||
| UniProt | O75365 | |
| EMBL | AF041434 AJ276554 BT007303 BC003105 U87168 | |
| CCDS | CCDS6382.1 CCDS6383.1 | |
| RefSeq | NP_009010.2 NP_116000.1 XP_005250819.1 XP_005250820.1 XP_005250821.1 XP_005250824.1 XP_006716562.1 XP_006725163.1 XP_006725164.1 XP_006725165.1 XP_006725166.1 | |
| UniGene | Hs.43666 Hs.744870 | |
| PDB | 1R6H 1V3A 2MBC | |
| PDBsum | 1R6H 1V3A 2MBC | |
| DisProt | DP00254 | |
| ProteinModelPortal | O75365 | |
| SMR | O75365 | |
| BioGrid | 116327 | |
| IntAct | O75365 | |
| STRING | 9606.ENSP00000332274 | |
| BindingDB | O75365 | |
| ChEMBL | CHEMBL4162 | |
| DEPOD | O75365 | |
| PhosphoSite | O75365 | |
| MaxQB | O75365 | |
| PaxDb | O75365 | |
| PRIDE | O75365 | |
| DNASU | 11156 | |
| Ensembl | ENST00000329397 ENST00000349124 ENST00000520105 ENST00000521578 ENST00000614325 ENST00000622569 | |
| GeneID | 11156 | |
| KEGG | hsa:11156 | |
| UCSC | uc003ywg.1 uc003ywh.1 | |
| CTD | 11156 | |
| GeneCards | GC08P142432 | |
| HGNC | HGNC:9636 | |
| HPA | HPA003281 | |
| MIM | 606449 | |
| neXtProt | NX_O75365 | |
| PharmGKB | PA33979 | |
| eggNOG | NOG265664 | |
| GeneTree | ENSGT00390000009788 | |
| HOGENOM | HOG000231265 | |
| HOVERGEN | HBG071295 | |
| InParanoid | O75365 | |
| KO | K18041 | |
| OMA | KAKFCDD | |
| OrthoDB | EOG7C8GJD | |
| PhylomeDB | O75365 | |
| TreeFam | TF313384 | |
| ChiTaRS | PTP4A3 | |
| EvolutionaryTrace | O75365 | |
| GeneWiki | PTP4A3 | |
| GenomeRNAi | 11156 | |
| NextBio | 42423 | |
| PRO | PR:O75365 | |
| Proteomes | UP000005640 UP000005640 | |
| Bgee | O75365 | |
| CleanEx | HS_PTP4A3 | |
| ExpressionAtlas | O75365 | |
| Genevestigator | O75365 | |
| GO | GO:0005769 GO:0005886 GO:0004727 GO:0043542 GO:0035335 | |
| Gene3D | 3.90.190.10 | |
| InterPro | IPR029021 IPR000387 IPR000242 | |
| Pfam | PF00102 | |
| SUPFAM | SSF52799 | |
| PROSITE | PS50056 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:1901224 |
positive regulation of NIK/NF-kappaB signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904951 |
positive regulation of establishment of protein localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043542 |
endothelial cell migration |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1277098 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0024734 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000597104 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000596945 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043542 |
endothelial cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008138 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004721 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004727 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1990830 |
cellular response to leukemia inhibitory factor |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9D658 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900746 |
regulation of vascular endothelial growth factor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9D658 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043542 |
endothelial cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9D658 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043117 |
positive regulation of vascular permeability |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9D658 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007219 |
Notch signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9D658 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008138 |
protein tyrosine/serine/threonine phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016791 |
phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004727 |
prenylated protein tyrosine phosphatase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005768 |
endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005769 |
early endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Lian, S et al. (2013) PRL-3 activates NF-κB signaling pathway by interacting with RAP1. Biochem. Biophys. Res. Commun. 430 196-201 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Zimmerman, MW et al. (2014) Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility. J. Biol. Chem. 289 5904-13 PubMed GONUTS page
- ↑ Zeng, Q et al. (1998) Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. Biochem. Biophys. Res. Commun. 244 421-7 PubMed GONUTS page
c
e
p
- GO:0035335 ! peptidyl-tyrosine dephosphorylation
- GO:0016791 ! phosphatase activity
- GO:0004721 ! phosphoprotein phosphatase activity
- GO:0005886 ! plasma membrane
- GO:1904951 ! positive regulation of establishment of protein localization
- GO:1901224 ! positive regulation of non-canonical NF-kappaB signal transduction
- GO:0043117 ! positive regulation of vascular permeability
- Primates
- GO:0006470 ! protein dephosphorylation
- GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity
- GO:0004725 ! protein tyrosine phosphatase activity
r
