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HUMAN:TOE1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TOE1 | |
| Protein Name(s) | Target of EGR1 protein 1 | |
| External Links | ||
| UniProt | Q96GM8 | |
| EMBL | AY169960 AK024011 AK293704 CR457320 AL359540 BC009364 | |
| CCDS | CCDS521.1 | |
| RefSeq | NP_079353.3 | |
| UniGene | Hs.525091 | |
| PDB | 2FC6 | |
| PDBsum | 2FC6 | |
| ProteinModelPortal | Q96GM8 | |
| SMR | Q96GM8 | |
| BioGrid | 125269 | |
| IntAct | Q96GM8 | |
| MINT | MINT-1378273 | |
| STRING | 9606.ENSP00000361162 | |
| iPTMnet | Q96GM8 | |
| PhosphoSitePlus | Q96GM8 | |
| BioMuta | TOE1 | |
| DMDM | 74751888 | |
| EPD | Q96GM8 | |
| MaxQB | Q96GM8 | |
| PaxDb | Q96GM8 | |
| PeptideAtlas | Q96GM8 | |
| PRIDE | Q96GM8 | |
| DNASU | 114034 | |
| Ensembl | ENST00000372090 | |
| GeneID | 114034 | |
| KEGG | hsa:114034 | |
| UCSC | uc009vxq.4 | |
| CTD | 114034 | |
| GeneCards | TOE1 | |
| HGNC | HGNC:15954 | |
| HPA | HPA053775 HPA069119 | |
| MIM | 613931 | |
| neXtProt | NX_Q96GM8 | |
| OpenTargets | ENSG00000132773 | |
| PharmGKB | PA38064 | |
| eggNOG | ENOG410IR2Y ENOG410XNUS | |
| GeneTree | ENSGT00390000004077 | |
| HOGENOM | HOG000231417 | |
| HOVERGEN | HBG080270 | |
| InParanoid | Q96GM8 | |
| KO | K13202 | |
| OMA | GFNFNRQ | |
| OrthoDB | EOG091G0L18 | |
| PhylomeDB | Q96GM8 | |
| TreeFam | TF314502 | |
| ChiTaRS | TOE1 | |
| EvolutionaryTrace | Q96GM8 | |
| GeneWiki | TOE1 | |
| GenomeRNAi | 114034 | |
| PMAP-CutDB | Q96GM8 | |
| PRO | PR:Q96GM8 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000132773 | |
| CleanEx | HS_TOE1 | |
| Genevisible | Q96GM8 | |
| GO | GO:0015030 GO:0005737 GO:0016604 GO:0016607 GO:0005730 GO:0005654 GO:0000175 GO:0046872 GO:0003676 GO:0004535 GO:0000289 GO:0090503 | |
| Gene3D | 3.30.420.10 | |
| InterPro | IPR006941 IPR012337 IPR000571 | |
| Pfam | PF04857 PF00642 | |
| SUPFAM | SSF53098 | |
| PROSITE | PS50103 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0072495 |
host cell Cajal body |
ECO:0000314 |
C |
FIGURE 4.B. Localization in HeLa cells 1 h after administration of recombinant EGFP-TOE1 fusion protein. Fusion protein involved a 6×His tag and were purified on a nickel column and administered to cultures of HeLa cells at a 1 μM concentration. CellMask Deep-Red plasma membrane stain was added immediately before live imaging at 0.25 μg/mL. |
complete | |||||
| GO:0015030 |
Cajal body |
ECO:0000314 |
C |
FIGURE 4.B. Localization in HeLa cells 1 h after administration of recombinant EGFP-TOE1 fusion protein. Fusion protein involved a 6×His tag and were purified on a nickel column and administered to cultures of HeLa cells at a 1 μM concentration. CellMask Deep-Red plasma membrane stain was added immediately before live imaging at 0.25 μg/mL. |
complete | |||||
|
enables |
GO:0017069 |
snRNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034472 |
snRNA 3'-end processing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0015030 |
Cajal body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000175 |
3'-5'-exoribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090503 |
RNA phosphodiester bond hydrolysis, exonucleolytic |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004535 |
poly(A)-specific ribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034472 |
snRNA 3'-end processing |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387148 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017069 |
snRNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387148 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0015030 |
Cajal body |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387148 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387146 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000175 |
3'-5'-exoribonuclease activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000387146 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016604 |
nuclear body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Sperandio, S et al. (2015) TOE1 is an inhibitor of HIV-1 replication with cell-penetrating capability. Proc. Natl. Acad. Sci. U.S.A. 112 E3392-401 PubMed GONUTS page
- ↑ 2.0 2.1 Lardelli, RM et al. (2017) Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing. Nat. Genet. 49 457-464 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Wagner, E et al. (2007) An unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodies. Mol. Cell. Biol. 27 1686-95 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
