HUMAN:TNFB

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	LTA (synonyms: TNFB, TNFSF1)
Protein Name(s)	Lymphotoxin-alpha LT-alpha TNF-beta Tumor necrosis factor ligand superfamily member 1
External Links
UniProt	P01374
EMBL	X01393 X02911 D00102 M16441 D12614 M55913 Z15026 Y14768 AF129756 BA000025 AY070490 AY216498 BC034729
CCDS	CCDS4701.1
PIR	A92755
RefSeq	NP_000586.2 NP_001153212.1
UniGene	Hs.36
PDB	1TNR 4MXV 4MXW
PDBsum	1TNR 4MXV 4MXW
ProteinModelPortal	P01374
SMR	P01374
BioGrid	110227
DIP	DIP-2910N DIP-6228N
IntAct	P01374
MINT	MINT-365276
STRING	9606.ENSP00000372793
BindingDB	P01374
ChEMBL	CHEMBL2059
DrugBank	DB00005
UniCarbKB	P01374
DMDM	135940
PRIDE	P01374
DNASU	4049
Ensembl	ENST00000412851 ENST00000418386 ENST00000426845 ENST00000436519 ENST00000454550 ENST00000454783
GeneID	4049
KEGG	hsa:4049
UCSC	uc003nue.2
CTD	4049
GeneCards	GC06P031541 GC06Pl31579 GC06Po31529
HGNC	HGNC:6709
HPA	HPA007729
MIM	153440 607507 610988
neXtProt	NX_P01374
Orphanet	40050
PharmGKB	PA30474
eggNOG	NOG41746
HOGENOM	HOG000048729
HOVERGEN	HBG012516
InParanoid	P01374
KO	K05468
OMA	YTLLTHE
OrthoDB	EOG7V4B0Q
PhylomeDB	P01374
TreeFam	TF332169
EvolutionaryTrace	P01374
GeneWiki	Lymphotoxin_alpha
GenomeRNAi	4049
NextBio	15860
PRO	PR:P01374
Proteomes	UP000005640 UP000005640
Bgee	P01374
CleanEx	HS_LTA
ExpressionAtlas	P01374
Genevestigator	P01374
GO	GO:0005615 GO:0016020 GO:0005102 GO:0006915 GO:0007267 GO:0050830 GO:0006959 GO:0048535 GO:0048147 GO:0044130 GO:0043065 GO:0002876 GO:0060252 GO:0002925 GO:0032729 GO:0042493 GO:0001666 GO:0032496 GO:0007584 GO:0007165
Gene3D	2.60.120.40
InterPro	IPR006053 IPR002960 IPR021184 IPR006052 IPR008983
Pfam	PF00229
PRINTS	PR01234 PR01236
SMART	SM00207
SUPFAM	SSF49842
PROSITE	PS00251 PS50049

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09225 ensembl:ENSMUSP00000025266	P		Seeded From UniProt	complete
involved_in	GO:0048535	lymph node development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09225 ensembl:ENSMUSP00000025266	P		Seeded From UniProt	complete
involved_in	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09225 ensembl:ENSMUSP00000025266	P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09225 ensembl:ENSMUSP00000025266	P		Seeded From UniProt	complete
involved_in	GO:0006959	humoral immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09225 ensembl:ENSMUSP00000025266	P		Seeded From UniProt	complete
involved_in	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09225 ensembl:ENSMUSP00000025266	P		Seeded From UniProt	complete
involved_in	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09225 ensembl:ENSMUSP00000025266	P		Seeded From UniProt	complete
involved_in	GO:0060252	positive regulation of glial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06332 ensembl:ENSRNOP00000001111	P		Seeded From UniProt	complete
involved_in	GO:0048147	negative regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06332 ensembl:ENSRNOP00000001111	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06332 ensembl:ENSRNOP00000001111	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06332 ensembl:ENSRNOP00000001111	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06332 ensembl:ENSRNOP00000001111	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06332 ensembl:ENSRNOP00000001111	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06332 ensembl:ENSRNOP00000001111	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06332 ensembl:ENSRNOP00000001111	P		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002960 InterPro:IPR006052 InterPro:IPR006053	F		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002960 InterPro:IPR006052 InterPro:IPR006053	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002960 InterPro:IPR006052 InterPro:IPR006053	C		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:6334807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:6334807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:6334807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:3001529	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	Reactome:R-HSA-5676594 Reactome:R-HSA-5668541	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5676593 Reactome:R-HSA-5676591 Reactome:R-HSA-5669097 Reactome:R-HSA-5668481 Reactome:R-HSA-5668454 Reactome:R-HSA-5668414	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
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References

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