HUMAN:TNF11

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TNFSF11 (synonyms: OPGL, RANKL, TRANCE)
Protein Name(s)	Tumor necrosis factor ligand superfamily member 11 Osteoclast differentiation factor ODF Osteoprotegerin ligand OPGL Receptor activator of nuclear factor kappa-B ligand RANKL TNF-related activation-induced cytokine TRANCE Tumor necrosis factor ligand superfamily member 11, membrane form Tumor necrosis factor ligand superfamily member 11, soluble form
External Links
UniProt	O14788
EMBL	AF019047 AF053712 AB064269 AB061227 AB064270 AB037599 BC074823 BC074890 AF013171
CCDS	CCDS9384.1 CCDS9385.1
RefSeq	NP_003692.1 NP_143026.1
UniGene	Hs.333791
PDB	3URF
PDBsum	3URF
ProteinModelPortal	O14788
SMR	O14788
BioGrid	114160
IntAct	O14788
MINT	MINT-8247611
STRING	9606.ENSP00000239849
ChEMBL	CHEMBL2364162
DrugBank	DB06643 DB00480
PhosphoSite	O14788
PaxDb	O14788
PRIDE	O14788
Ensembl	ENST00000239849 ENST00000358545 ENST00000398795 ENST00000405262 ENST00000544862
GeneID	8600
KEGG	hsa:8600
UCSC	uc001uyt.2
CTD	8600
GeneCards	GC13P043136
HGNC	HGNC:11926
HPA	CAB009193
MIM	259710 602642
neXtProt	NX_O14788
Orphanet	667
PharmGKB	PA36619
eggNOG	NOG40842
GeneTree	ENSGT00530000063443
HOGENOM	HOG000132981
HOVERGEN	HBG054257
InParanoid	O14788
KO	K05473
OMA	DIPSGSH
OrthoDB	EOG7V4B0Q
PhylomeDB	O14788
TreeFam	TF332169
GeneWiki	RANKL
GenomeRNAi	8600
NextBio	32221
PMAP-CutDB	O14788
PRO	PR:O14788
Proteomes	UP000005640
Bgee	O14788
CleanEx	HS_TNFSF11
ExpressionAtlas	O14788
Genevestigator	O14788
GO	GO:0005737 GO:0005576 GO:0005615 GO:0005887 GO:0005125 GO:0005164 GO:0032813 GO:0007257 GO:0045453 GO:0055074 GO:0019221 GO:0070371 GO:0006955 GO:0060749 GO:0033598 GO:0002548 GO:0009887 GO:0001503 GO:0030316 GO:0002158 GO:0045780 GO:0051466 GO:0071848 GO:0071812 GO:0034112 GO:0043123 GO:1902533 GO:0043406 GO:0051092 GO:2001206 GO:0045672 GO:0051897 GO:0051091 GO:0050870 GO:0045944 GO:0051260 GO:0071847 GO:0033209
Gene3D	2.60.120.40
InterPro	IPR006052 IPR017355 IPR008983
Pfam	PF00229
PIRSF	PIRSF038013
SMART	SM00207
SUPFAM	SSF49842
PROSITE	PS50049

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0045672	positive regulation of osteoclast differentiation	PMID:19560569^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35235	P	Seeded From UniProt	complete
involved_in	GO:1902533	positive regulation of intracellular signal transduction	PMID:15248232^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071848	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	PMID:18606301^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071847	TNFSF11-mediated signaling pathway	PMID:18606301^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071812	positive regulation of fever generation by positive regulation of prostaglandin secretion	PMID:19940926^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35235	P	Seeded From UniProt	complete
involved_in	GO:0051466	positive regulation of corticotropin-releasing hormone secretion	PMID:19940926^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35235	P	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:9367155^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:19940926^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35235	P	Seeded From UniProt	complete
involved_in	GO:0050870	positive regulation of T cell activation	PMID:9367155^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15304486^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045672	positive regulation of osteoclast differentiation	PMID:15304486^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:15304486^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034112	positive regulation of homotypic cell-cell adhesion	PMID:9367155^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:19940926^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35235	P	Seeded From UniProt	complete
enables	GO:0032813	tumor necrosis factor receptor superfamily binding	PMID:19940926^[4]	ECO:0000305	curator inference used in manual assertion	GO:0033209	F	Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	PMID:18606301^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35235	P	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:15248232^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:15248232^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:9367155^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0002548	monocyte chemotaxis	PMID:15248232^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045780	positive regulation of bone resorption	PMID:17241109^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045672	positive regulation of osteoclast differentiation	PMID:17241109^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	PMID:9568710^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:9312132^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9312132^[9]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:10708588^[10]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:9568710^[8]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:9367155^[5]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:9312132^[9]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:9568710^[8]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:2001206	positive regulation of osteoclast development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:1990830	cellular response to leukemia inhibitory factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:1904616	regulation of actin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0071847	TNFSF11-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0071812	positive regulation of fever generation by positive regulation of prostaglandin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0060749	mammary gland alveolus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0055074	calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0051466	positive regulation of corticotropin-releasing hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0045672	positive regulation of osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0045670	regulation of osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0045453	bone resorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0044691	tooth eruption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0038001	paracrine signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0036035	osteoclast development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0033598	mammary gland epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
enables	GO:0032813	tumor necrosis factor receptor superfamily binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	F	Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0002158	osteoclast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35235 ensembl:ENSMUSP00000022592	P	Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006052	F	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006052	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006052	C	Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	Reactome:R-HSA-5676594 Reactome:R-HSA-5668541	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5676595 Reactome:R-HSA-5676592 Reactome:R-HSA-5676589 Reactome:R-HSA-5669035 Reactome:R-HSA-5668481 Reactome:R-HSA-5668454 Reactome:R-HSA-5668414	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-5676595 Reactome:R-HSA-5676592 Reactome:R-HSA-5676589 Reactome:R-HSA-5669035 Reactome:R-HSA-5668481 Reactome:R-HSA-5668454 Reactome:R-HSA-5668414	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kotake, S et al. (2009) T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. Bone 45 627-39 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Mosheimer, BA et al. (2004) Expression and function of RANK in human monocyte chemotaxis. Arthritis Rheum. 50 2309-16 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Guerrini, MM et al. (2008) Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations. Am. J. Hum. Genet. 83 64-76 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Hanada, R et al. (2009) Central control of fever and female body temperature by RANKL/RANK. Nature 462 505-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Anderson, DM et al. (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390 175-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Matsumoto, M et al. (2004) Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. J. Biol. Chem. 279 45969-79 PubMed GONUTS page
↑ ^7.0 ^7.1 Fuller, K et al. (2007) Regulation and enzymatic basis of bone resorption by human osteoclasts. Clin. Sci. 112 567-75 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Lacey, DL et al. (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93 165-76 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Wong, BR et al. (1997) TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J. Biol. Chem. 272 25190-4 PubMed GONUTS page
↑ Nagai, M et al. (2000) Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation. Biochem. Biophys. Res. Commun. 269 532-6 PubMed GONUTS page

[PMID:19560569-1] Kotake, S et al. (2009) T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. Bone 45 627-39 PubMed GONUTS page

[PMID:15248232-2] 2.0 ^2.1 ^2.2 ^2.3 Mosheimer, BA et al. (2004) Expression and function of RANK in human monocyte chemotaxis. Arthritis Rheum. 50 2309-16 PubMed GONUTS page

[PMID:18606301-3] 3.0 ^3.1 ^3.2 Guerrini, MM et al. (2008) Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations. Am. J. Hum. Genet. 83 64-76 PubMed GONUTS page

[PMID:19940926-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Hanada, R et al. (2009) Central control of fever and female body temperature by RANKL/RANK. Nature 462 505-9 PubMed GONUTS page

[PMID:9367155-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Anderson, DM et al. (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390 175-9 PubMed GONUTS page

[PMID:15304486-6] 6.0 ^6.1 ^6.2 Matsumoto, M et al. (2004) Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. J. Biol. Chem. 279 45969-79 PubMed GONUTS page

[PMID:17241109-7] 7.0 ^7.1 Fuller, K et al. (2007) Regulation and enzymatic basis of bone resorption by human osteoclasts. Clin. Sci. 112 567-75 PubMed GONUTS page

[PMID:9568710-8] 8.0 ^8.1 ^8.2 Lacey, DL et al. (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93 165-76 PubMed GONUTS page

[PMID:9312132-9] 9.0 ^9.1 ^9.2 Wong, BR et al. (1997) TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J. Biol. Chem. 272 25190-4 PubMed GONUTS page

[PMID:10708588-10] Nagai, M et al. (2000) Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation. Biochem. Biophys. Res. Commun. 269 532-6 PubMed GONUTS page

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HUMAN:TNF11

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