HUMAN:TIRAP

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TIRAP (synonyms: MAL)
Protein Name(s)	Toll/interleukin-1 receptor domain-containing adapter protein TIR domain-containing adapter protein Adaptor protein Wyatt MyD88 adapter-like protein MyD88-2
External Links
UniProt	P58753
EMBL	AF406652 AF378129 AF410783 AY576785 AY576786 AY576787 AB446477 AK124298 AK313147 AY282416 AP001318 CH471065 CH471065 BC032474
CCDS	CCDS41731.1 CCDS8472.1
RefSeq	NP_001034750.1 NP_683708.1
UniGene	Hs.537126
PDB	2Y92 3UB2 3UB3 3UB4 4FZ5 4LQD
PDBsum	2Y92 3UB2 3UB3 3UB4 4FZ5 4LQD
ProteinModelPortal	P58753
SMR	P58753
BioGrid	125325
DIP	DIP-33489N
IntAct	P58753
MINT	MINT-4950450
STRING	9606.ENSP00000376445
PhosphoSite	P58753
DMDM	50403750
PaxDb	P58753
PRIDE	P58753
DNASU	114609
Ensembl	ENST00000392678 ENST00000392679 ENST00000392680 ENST00000479770
GeneID	114609
KEGG	hsa:114609
UCSC	uc001qdl.1 uc001qdm.1
CTD	114609
GeneCards	GC11P126153
HGNC	HGNC:17192
HPA	HPA054431
MIM	606252 607948 610799 611162 614382
neXtProt	NX_P58753
PharmGKB	PA134972842
eggNOG	NOG80263
GeneTree	ENSGT00510000048428
HOGENOM	HOG000068972
HOVERGEN	HBG054203
InParanoid	P58753
KO	K05403
OMA	AELRFMY
PhylomeDB	P58753
TreeFam	TF330734
Reactome	REACT_6788 REACT_6894
SignaLink	P58753
GenomeRNAi	114609
NextBio	79099
PRO	PR:P58753
Proteomes	UP000005640
Bgee	P58753
CleanEx	HS_MAL HS_TIRAP
ExpressionAtlas	P58753
Genevestigator	P58753
GO	GO:0005737 GO:0005829 GO:0030139 GO:0005886 GO:0032587 GO:0005546 GO:0030674 GO:0046982 GO:0042803 GO:0005080 GO:0035663 GO:0035662 GO:0070935 GO:0007166 GO:0071221 GO:0071223 GO:0050830 GO:0007249 GO:0006954 GO:0045087 GO:0002755 GO:0030099 GO:0044130 GO:0030890 GO:2000340 GO:2000343 GO:0070374 GO:0043123 GO:0032735 GO:0032738 GO:0045410 GO:0032757 GO:0046330 GO:0090023 GO:0051092 GO:0090073 GO:0034137 GO:0034141 GO:0034145 GO:0032760 GO:0045088 GO:0032648 GO:0032496 GO:0035665 GO:0034134 GO:0034142 GO:0002224 GO:0038123 GO:0038124
Gene3D	3.40.50.10140
InterPro	IPR000157 IPR017279
PANTHER	PTHR22662
Pfam	PF13676
PIRSF	PIRSF037750
SUPFAM	SSF52200
PROSITE	PS50104

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0007250	activation of NF-kappaB-inducing kinase activity	PMID:24275656^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	P	Seeded From UniProt	complete
involved_in	GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	P	Seeded From UniProt	complete
involved_in	GO:0090073	positive regulation of protein homodimerization activity	PMID:12062447^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090023	positive regulation of neutrophil chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	P	Seeded From UniProt	complete
involved_in	GO:0071223	cellular response to lipoteichoic acid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	P	Seeded From UniProt	complete
involved_in	GO:0071221	cellular response to bacterial lipopeptide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	P	Seeded From UniProt	complete
involved_in	GO:0070935	3'-UTR-mediated mRNA stabilization	PMID:15294994^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:11544529^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:19509286^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:19509286^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:11544529^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045410	positive regulation of interleukin-6 biosynthetic process	PMID:16301656^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045088	regulation of innate immune response	PMID:19509286^[5]	ECO:0000305	curator inference used in manual assertion	GO:0034145	P	Seeded From UniProt	complete
involved_in	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	P	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:19509286^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	F	Seeded From UniProt	complete
involved_in	GO:0035665	TIRAP-dependent toll-like receptor 4 signaling pathway	PMID:11544529^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0035663	Toll-like receptor 2 binding	PMID:19509286^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60603	F	Seeded From UniProt	complete
enables	GO:0035662	Toll-like receptor 4 binding	PMID:19509286^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O00206	F	Seeded From UniProt	complete
involved_in	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	PMID:19509286^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	P	Seeded From UniProt	complete
involved_in	GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	PMID:19509286^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:16301656^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:19509286^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	PMID:16301656^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032738	positive regulation of interleukin-15 production	PMID:18583567^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032735	positive regulation of interleukin-12 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	P	Seeded From UniProt	complete
involved_in	GO:0032648	regulation of interferon-beta production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	P	Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	C	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:11544529^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	P	Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	PMID:19509286^[5]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	C	Seeded From UniProt	complete
involved_in	GO:0030099	myeloid cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	P	Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	P	Seeded From UniProt	complete
enables	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99JY1	F	Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	PMID:17161867^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09215	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19948740^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19948740^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24275656^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P58753	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17258210^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P58753	F	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000157	P	Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	PMID:19509286^[5] Reactome:R-HSA-166058	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-937079 Reactome:R-HSA-937059 Reactome:R-HSA-937022 Reactome:R-HSA-5602672 Reactome:R-HSA-5602383 Reactome:R-HSA-5602353 Reactome:R-HSA-2262777 Reactome:R-HSA-2262775 Reactome:R-HSA-2201322 Reactome:R-HSA-166363 Reactome:R-HSA-166362 Reactome:R-HSA-166286 Reactome:R-HSA-166284 Reactome:R-HSA-166119 Reactome:R-HSA-166091 Reactome:R-HSA-166082 Reactome:R-HSA-166072	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5602606 Reactome:R-HSA-2559456 Reactome:R-HSA-2559414 Reactome:R-HSA-2201322 Reactome:R-HSA-2201316	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Snyder, GA et al. (2014) Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. J. Biol. Chem. 289 669-79 PubMed GONUTS page
↑ Shinobu, N et al. (2002) Involvement of TIRAP/MAL in signaling for the activation of interferon regulatory factor 3 by lipopolysaccharide. FEBS Lett. 517 251-6 PubMed GONUTS page
↑ Datta, S et al. (2004) Toll IL-1 receptors differ in their ability to promote the stabilization of adenosine and uridine-rich elements containing mRNA. J. Immunol. 173 2755-61 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Fitzgerald, KA et al. (2001) Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413 78-83 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 Nagpal, K et al. (2009) A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. J. Biol. Chem. 284 25742-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Jeyaseelan, S et al. (2005) Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli. J. Immunol. 175 7484-95 PubMed GONUTS page
↑ Ahmad, R et al. (2008) Requirement of TLR2-mediated signaling for the induction of IL-15 gene expression in human monocytic cells by HSV-1. Blood 112 2360-8 PubMed GONUTS page
↑ Kubo-Murai, M et al. (2007) Protein kinase Cdelta binds TIRAP/Mal to participate in TLR signaling. Mol. Immunol. 44 2257-64 PubMed GONUTS page
↑ ^9.0 ^9.1 Wan, T et al. (2010) AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling. J. Biol. Chem. 285 3750-7 PubMed GONUTS page
↑ Ulrichts, P et al. (2007) MAPPIT analysis of TLR adaptor complexes. FEBS Lett. 581 629-36 PubMed GONUTS page

[PMID:24275656-1] 1.0 ^1.1 Snyder, GA et al. (2014) Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. J. Biol. Chem. 289 669-79 PubMed GONUTS page

[PMID:12062447-2] Shinobu, N et al. (2002) Involvement of TIRAP/MAL in signaling for the activation of interferon regulatory factor 3 by lipopolysaccharide. FEBS Lett. 517 251-6 PubMed GONUTS page

[PMID:15294994-3] Datta, S et al. (2004) Toll IL-1 receptors differ in their ability to promote the stabilization of adenosine and uridine-rich elements containing mRNA. J. Immunol. 173 2755-61 PubMed GONUTS page

[PMID:11544529-4] 4.0 ^4.1 ^4.2 ^4.3 Fitzgerald, KA et al. (2001) Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413 78-83 PubMed GONUTS page

[PMID:19509286-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 Nagpal, K et al. (2009) A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. J. Biol. Chem. 284 25742-8 PubMed GONUTS page

[PMID:16301656-6] 6.0 ^6.1 ^6.2 Jeyaseelan, S et al. (2005) Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli. J. Immunol. 175 7484-95 PubMed GONUTS page

[PMID:18583567-7] Ahmad, R et al. (2008) Requirement of TLR2-mediated signaling for the induction of IL-15 gene expression in human monocytic cells by HSV-1. Blood 112 2360-8 PubMed GONUTS page

[PMID:17161867-8] Kubo-Murai, M et al. (2007) Protein kinase Cdelta binds TIRAP/Mal to participate in TLR signaling. Mol. Immunol. 44 2257-64 PubMed GONUTS page

[PMID:19948740-9] 9.0 ^9.1 Wan, T et al. (2010) AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling. J. Biol. Chem. 285 3750-7 PubMed GONUTS page

[PMID:17258210-10] Ulrichts, P et al. (2007) MAPPIT analysis of TLR adaptor complexes. FEBS Lett. 581 629-36 PubMed GONUTS page

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HUMAN:TIRAP

Contents

Annotations

Notes

References

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