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HUMAN:TGBR3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TGFBR3
Protein Name(s) Transforming growth factor beta receptor type 3

TGF-beta receptor type 3 TGFR-3 Betaglycan Transforming growth factor beta receptor III TGF-beta receptor type III

External Links
UniProt Q03167
EMBL L07594
AJ251961
AY796304
AK291345
AL162263
AL390780
AL445992
AL162263
AC099334
AL390780
AL445992
AL390780
AL162263
AL445992
AL390780
AC099334
AL162263
AL445992
AL445992
AL162263
AL390780
AL445992
AC099334
AL162263
AL390780
BC126116
BC136295
CCDS CCDS30770.1
CCDS55614.1
PIR JC1350
RefSeq NP_001182612.1
NP_001182613.1
NP_003234.2
XP_006710930.1
XP_006710931.1
UniGene Hs.482390
Hs.735919
ProteinModelPortal Q03167
SMR Q03167
BioGrid 112907
DIP DIP-5940N
IntAct Q03167
MINT MINT-1785606
STRING 9606.ENSP00000212355
PhosphoSite Q03167
DMDM 311033535
MaxQB Q03167
PaxDb Q03167
PRIDE Q03167
Ensembl ENST00000212355
ENST00000370399
ENST00000465892
ENST00000525962
GeneID 7049
KEGG hsa:7049
UCSC uc001doh.3
uc001doi.3
CTD 7049
GeneCards GC01M092145
H-InvDB HIX0028622
HGNC HGNC:11774
HPA CAB018971
HPA008257
MIM 600742
neXtProt NX_Q03167
Orphanet 231160
PharmGKB PA36487
eggNOG NOG40778
GeneTree ENSGT00530000063861
HOGENOM HOG000090193
HOVERGEN HBG057515
InParanoid Q03167
KO K05843
OMA FAIQTCF
OrthoDB EOG72ZCDK
PhylomeDB Q03167
TreeFam TF337375
ChiTaRS TGFBR3
GeneWiki TGFBR3
GenomeRNAi 7049
NextBio 27547
PRO PR:Q03167
Proteomes UP000005640
Bgee Q03167
CleanEx HS_TGFBR3
ExpressionAtlas Q03167
Genevestigator Q03167
GO GO:0009986
GO:0005783
GO:0009897
GO:0005615
GO:0070062
GO:0034673
GO:0005887
GO:0005578
GO:0015026
GO:0005539
GO:0008201
GO:0030165
GO:0046332
GO:0050431
GO:0070123
GO:0005160
GO:0005024
GO:0005114
GO:0001824
GO:0001568
GO:0030509
GO:0060317
GO:0060038
GO:0016049
GO:0016477
GO:0060318
GO:0060216
GO:0001837
GO:0003007
GO:0060347
GO:0006955
GO:0035556
GO:0001889
GO:0051271
GO:0010633
GO:0050680
GO:0010719
GO:0030512
GO:0031100
GO:0060021
GO:0060389
GO:0051092
GO:0030511
GO:0043393
GO:0032354
GO:0001666
GO:0034699
GO:0034695
GO:0007181
GO:0007179
GO:0055010
InterPro IPR001507
IPR017977
Pfam PF00100
PRINTS PR00023
SMART SM00241
PROSITE PS00682
PS51034

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

NOT|involved_in

GO:0070372

regulation of ERK1 and ERK2 cascade

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0061384

heart trabecula morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0060045

positive regulation of cardiac muscle cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

NOT|involved_in

GO:0046328

regulation of JNK cascade

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0003150

muscular septum morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0060979

vasculogenesis involved in coronary vascular morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0060939

epicardium-derived cardiac fibroblast cell development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0060412

ventricular septum morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0003223

ventricular compact myocardium morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0003151

outflow tract morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

has_input:(UniProtKB:P61812)

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:11157754[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19199708[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:16502470[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001914)

Seeded From UniProt

complete

enables

GO:0070123

transforming growth factor beta receptor activity, type III

PMID:11157754[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0070123

transforming growth factor beta receptor activity, type III

PMID:10746731[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060389

pathway-restricted SMAD protein phosphorylation

PMID:11157754[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060347

heart trabecula formation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0060318

definitive erythrocyte differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0060317

cardiac epithelial to mesenchymal transition

PMID:18184661[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060216

definitive hemopoiesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0060038

cardiac muscle cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0062009

secondary palate development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0055010

ventricular cardiac muscle tissue morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0051271

negative regulation of cellular component movement

PMID:17999987[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050680

negative regulation of epithelial cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

PMID:12958365[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

PMID:11157754[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0046332

SMAD binding

PMID:11157754[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:14557487[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034699

response to luteinizing hormone

PMID:14557487[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034695

response to prostaglandin E

PMID:14557487[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034673

inhibin-betaglycan-ActRII complex

PMID:10746731[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032354

response to follicle-stimulating hormone

PMID:14557487[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

PMID:18184661[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030165

PDZ domain binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

F

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q90998

P

Seeded From UniProt

complete

enables

GO:0015026

coreceptor activity

PMID:10746731[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

C

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:12958365[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

PMID:1333192[10]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26342

F

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:11157754[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:12958365[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:16886151[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q90998

C

Seeded From UniProt

complete

enables

GO:0005539

glycosaminoglycan binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

F

Seeded From UniProt

complete

contributes_to

GO:0050431

transforming growth factor beta binding

PMID:11157754[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P61812

F

Seeded From UniProt

complete

enables

GO:0005160

transforming growth factor beta receptor binding

PMID:1333192[10]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26342

F

Seeded From UniProt

complete

enables

GO:0005114

type II transforming growth factor beta receptor binding

PMID:11157754[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005024

transforming growth factor beta-activated receptor activity

PMID:12958365[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0003007

heart morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q90998

P

Seeded From UniProt

complete

involved_in

GO:0001889

liver development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88393

P

Seeded From UniProt

complete

involved_in

GO:0001837

epithelial to mesenchymal transition

PMID:18184661[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070123

transforming growth factor beta receptor activity, type III

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

F

Seeded From UniProt

complete

involved_in

GO:0065003

protein-containing complex assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

P

Seeded From UniProt

complete

enables

GO:0050431

transforming growth factor beta binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

F

Seeded From UniProt

complete

enables

GO:0048185

activin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

F

Seeded From UniProt

complete

involved_in

GO:0043393

regulation of protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

P

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

C

Seeded From UniProt

complete

involved_in

GO:0031100

animal organ regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

P

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

C

Seeded From UniProt

complete

involved_in

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

P

Seeded From UniProt

complete

involved_in

GO:0030511

positive regulation of transforming growth factor beta receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

P

Seeded From UniProt

complete

enables

GO:0017134

fibroblast growth factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

C

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

F

Seeded From UniProt

complete

involved_in

GO:0007181

transforming growth factor beta receptor complex assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

C

Seeded From UniProt

complete

enables

GO:0005160

transforming growth factor beta receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

F

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26342
ensembl:ENSRNOP00000002867

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:18184661[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005539

glycosaminoglycan binding

PMID:1333192[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0112

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Rotzer, D et al. (2001) Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor. EMBO J. 20 480-90 PubMed GONUTS page
  2. Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  3. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  4. Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
  5. 5.0 5.1 5.2 Lewis, KA et al. (2000) Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature 404 411-4 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Kirkbride, KC et al. (2008) Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor. J. Biol. Chem. 283 7628-37 PubMed GONUTS page
  7. Gordon, KJ et al. (2008) Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression. Carcinogenesis 29 252-62 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Chen, W et al. (2003) Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. Science 301 1394-7 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 Liu, J et al. (2003) Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells. J. Clin. Endocrinol. Metab. 88 5002-8 PubMed GONUTS page
  10. 10.0 10.1 10.2 Morén, A et al. (1992) Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors. Biochem. Biophys. Res. Commun. 189 356-62 PubMed GONUTS page
  11. Adewoye, AH et al. (2006) Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia. Clin. Infect. Dis. 43 593-8 PubMed GONUTS page