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HUMAN:TGBR3
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | TGFBR3 | |
Protein Name(s) | Transforming growth factor beta receptor type 3
TGF-beta receptor type 3 TGFR-3 Betaglycan Transforming growth factor beta receptor III TGF-beta receptor type III | |
External Links | ||
UniProt | Q03167 | |
EMBL | L07594 AJ251961 AY796304 AK291345 AL162263 AL390780 AL445992 AL162263 AC099334 AL390780 AL445992 AL390780 AL162263 AL445992 AL390780 AC099334 AL162263 AL445992 AL445992 AL162263 AL390780 AL445992 AC099334 AL162263 AL390780 BC126116 BC136295 | |
CCDS | CCDS30770.1 CCDS55614.1 | |
PIR | JC1350 | |
RefSeq | NP_001182612.1 NP_001182613.1 NP_003234.2 XP_006710930.1 XP_006710931.1 | |
UniGene | Hs.482390 Hs.735919 | |
ProteinModelPortal | Q03167 | |
SMR | Q03167 | |
BioGrid | 112907 | |
DIP | DIP-5940N | |
IntAct | Q03167 | |
MINT | MINT-1785606 | |
STRING | 9606.ENSP00000212355 | |
PhosphoSite | Q03167 | |
DMDM | 311033535 | |
MaxQB | Q03167 | |
PaxDb | Q03167 | |
PRIDE | Q03167 | |
Ensembl | ENST00000212355 ENST00000370399 ENST00000465892 ENST00000525962 | |
GeneID | 7049 | |
KEGG | hsa:7049 | |
UCSC | uc001doh.3 uc001doi.3 | |
CTD | 7049 | |
GeneCards | GC01M092145 | |
H-InvDB | HIX0028622 | |
HGNC | HGNC:11774 | |
HPA | CAB018971 HPA008257 | |
MIM | 600742 | |
neXtProt | NX_Q03167 | |
Orphanet | 231160 | |
PharmGKB | PA36487 | |
eggNOG | NOG40778 | |
GeneTree | ENSGT00530000063861 | |
HOGENOM | HOG000090193 | |
HOVERGEN | HBG057515 | |
InParanoid | Q03167 | |
KO | K05843 | |
OMA | FAIQTCF | |
OrthoDB | EOG72ZCDK | |
PhylomeDB | Q03167 | |
TreeFam | TF337375 | |
ChiTaRS | TGFBR3 | |
GeneWiki | TGFBR3 | |
GenomeRNAi | 7049 | |
NextBio | 27547 | |
PRO | PR:Q03167 | |
Proteomes | UP000005640 | |
Bgee | Q03167 | |
CleanEx | HS_TGFBR3 | |
ExpressionAtlas | Q03167 | |
Genevestigator | Q03167 | |
GO | GO:0009986 GO:0005783 GO:0009897 GO:0005615 GO:0070062 GO:0034673 GO:0005887 GO:0005578 GO:0015026 GO:0005539 GO:0008201 GO:0030165 GO:0046332 GO:0050431 GO:0070123 GO:0005160 GO:0005024 GO:0005114 GO:0001824 GO:0001568 GO:0030509 GO:0060317 GO:0060038 GO:0016049 GO:0016477 GO:0060318 GO:0060216 GO:0001837 GO:0003007 GO:0060347 GO:0006955 GO:0035556 GO:0001889 GO:0051271 GO:0010633 GO:0050680 GO:0010719 GO:0030512 GO:0031100 GO:0060021 GO:0060389 GO:0051092 GO:0030511 GO:0043393 GO:0032354 GO:0001666 GO:0034699 GO:0034695 GO:0007181 GO:0007179 GO:0055010 | |
InterPro | IPR001507 IPR017977 | |
Pfam | PF00100 | |
PRINTS | PR00023 | |
SMART | SM00241 | |
PROSITE | PS00682 PS51034 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
NOT|involved_in |
GO:0070372 |
regulation of ERK1 and ERK2 cascade |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061384 |
heart trabecula morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060045 |
positive regulation of cardiac muscle cell proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
NOT|involved_in |
GO:0046328 |
regulation of JNK cascade |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003150 |
muscular septum morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060979 |
vasculogenesis involved in coronary vascular morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060939 |
epicardium-derived cardiac fibroblast cell development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060412 |
ventricular septum morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003223 |
ventricular compact myocardium morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003151 |
outflow tract morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
has_input:(UniProtKB:P61812) |
Seeded From UniProt |
complete | ||
part_of |
GO:0043235 |
receptor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001831) |
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001914) |
Seeded From UniProt |
complete | ||
enables |
GO:0070123 |
transforming growth factor beta receptor activity, type III |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0070123 |
transforming growth factor beta receptor activity, type III |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060389 |
pathway-restricted SMAD protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060347 |
heart trabecula formation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060318 |
definitive erythrocyte differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060317 |
cardiac epithelial to mesenchymal transition |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060216 |
definitive hemopoiesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060038 |
cardiac muscle cell proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0062009 |
secondary palate development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055010 |
ventricular cardiac muscle tissue morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051271 |
negative regulation of cellular component movement |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050680 |
negative regulation of epithelial cell proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0050431 |
transforming growth factor beta binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0050431 |
transforming growth factor beta binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046332 |
SMAD binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034699 |
response to luteinizing hormone |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034695 |
response to prostaglandin E |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0034673 |
inhibin-betaglycan-ActRII complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032354 |
response to follicle-stimulating hormone |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030509 |
BMP signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0030165 |
PDZ domain binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016477 |
cell migration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0015026 |
coreceptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0009986 |
cell surface |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0008201 |
heparin binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006955 |
immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005539 |
glycosaminoglycan binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0050431 |
transforming growth factor beta binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005160 |
transforming growth factor beta receptor binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005114 |
type II transforming growth factor beta receptor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005024 |
transforming growth factor beta-activated receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003007 |
heart morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001889 |
liver development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001837 |
epithelial to mesenchymal transition |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0070123 |
transforming growth factor beta receptor activity, type III |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0065003 |
protein-containing complex assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0050431 |
transforming growth factor beta binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0048185 |
activin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043393 |
regulation of protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0043235 |
receptor complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031100 |
animal organ regeneration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030511 |
positive regulation of transforming growth factor beta receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0017134 |
fibroblast growth factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0008201 |
heparin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007181 |
transforming growth factor beta receptor complex assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005160 |
transforming growth factor beta receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001666 |
response to hypoxia |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26342 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005539 |
glycosaminoglycan binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Rotzer, D et al. (2001) Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor. EMBO J. 20 480-90 PubMed GONUTS page
- ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Lewis, KA et al. (2000) Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature 404 411-4 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Kirkbride, KC et al. (2008) Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor. J. Biol. Chem. 283 7628-37 PubMed GONUTS page
- ↑ Gordon, KJ et al. (2008) Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression. Carcinogenesis 29 252-62 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Chen, W et al. (2003) Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. Science 301 1394-7 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Liu, J et al. (2003) Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells. J. Clin. Endocrinol. Metab. 88 5002-8 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Morén, A et al. (1992) Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors. Biochem. Biophys. Res. Commun. 189 356-62 PubMed GONUTS page
- ↑ Adewoye, AH et al. (2006) Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia. Clin. Infect. Dis. 43 593-8 PubMed GONUTS page
c
e
- GO:0060939 ! epicardium-derived cardiac fibroblast cell development
- GO:0001837 ! epithelial to mesenchymal transition
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
- GO:0009897 ! external side of plasma membrane
- GO:0031012 ! extracellular matrix
- GO:0005615 ! extracellular space
- GO:0005576 ! extracellular region
- GO:0070062 ! extracellular exosome
h
i
n
o
p
r
- GO:0043235 ! receptor complex
- GO:0046328 ! regulation of JNK cascade
- GO:0070372 ! regulation of ERK1 and ERK2 cascade
- GO:0043393 ! regulation of protein binding
- GO:0001666 ! response to hypoxia
- GO:0032354 ! response to follicle-stimulating hormone
- GO:0034695 ! response to prostaglandin E
- GO:0034699 ! response to luteinizing hormone
t
- GO:0007179 ! transforming growth factor beta receptor signaling pathway
- GO:0050431 ! transforming growth factor beta binding
- GO:0005024 ! transforming growth factor beta receptor activity
- GO:0005160 ! transforming growth factor beta receptor binding
- GO:0070123 ! transforming growth factor beta receptor activity, type III
- GO:0007181 ! transforming growth factor beta receptor complex assembly
- GO:0005114 ! type II transforming growth factor beta receptor binding