GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:1333192

From GONUTS
Jump to: navigation, search
Citation

Morén, A, Ichijo, H and Miyazono, K (1992) Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors. Biochem. Biophys. Res. Commun. 189:356-62

Abstract

Full-length cDNAs for the transforming growth factor-beta (TGF-beta) type III receptors were isolated from porcine uterus and human placenta cDNA libraries. The human TGF-beta type III receptor coding region encodes a protein of 849 amino acids with a single transmembrane domain and a short stretch of the intracellular domain. Potential glycosaminoglycan attachment sites were found in the extracellular domain. The overall amino acid sequence identities with those of the porcine and rat TGF-beta type III receptors were 83% and 81%, respectively. A high degree of sequence conservation was observed in the transmembrane and intracellular domains, which also have sequence similarity with human endoglin. In addition, two portions with 29 and 52 amino acids in the extracellular domain were found to be substantially similar with human endoglin.

Links

PubMed

Keywords

Amino Acid Sequence; Animals; Antigens, CD; Base Sequence; Cloning, Molecular; DNA/genetics; DNA/isolation & purification; Female; Gene Library; Humans; Membrane Glycoproteins/genetics; Molecular Sequence Data; Placenta/physiology; Polymerase Chain Reaction/methods; Pregnancy; Receptors, Cell Surface/genetics; Receptors, Cell Surface/metabolism; Receptors, Transforming Growth Factor beta; Sequence Homology, Amino Acid; Swine; Transforming Growth Factor beta/metabolism; Uterus/physiology; Vascular Cell Adhesion Molecule-1

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:TGBR3

enables

GO:0005539: glycosaminoglycan binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

RAT:TGBR3

located_in

GO:0016021: integral component of membrane

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

RAT:TGBR3

involved_in

GO:0007165: signal transduction

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

RAT:TGBR3

located_in

GO:0062023: collagen-containing extracellular matrix

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

RAT:TGBR3

enables

GO:0050431: transforming growth factor beta binding

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

PIG:TGBR3

enables

GO:0005160: transforming growth factor beta receptor binding

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P26342

F

Seeded From UniProt

complete

PIG:TGBR3

enables

GO:0005539: glycosaminoglycan binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

PIG:TGBR3

enables

GO:0008201: heparin binding

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P26342

F

Seeded From UniProt

complete

PIG:TGBR3

involved_in

GO:0001837: epithelial to mesenchymal transition

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:Q03167

P

Seeded From UniProt

complete

PIG:TGBR3

located_in

GO:0009897: external side of plasma membrane

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:Q03167

C

Seeded From UniProt

complete

PIG:TGBR3

located_in

GO:0016021: integral component of membrane

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P26342

C

Seeded From UniProt

complete

PIG:TGBR3

located_in

GO:0016021: integral component of membrane

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

PIG:TGBR3

involved_in

GO:0032354: response to follicle-stimulating hormone

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:Q03167

P

Seeded From UniProt

complete

PIG:TGBR3

involved_in

GO:0007179: transforming growth factor beta receptor signaling pathway

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:Q03167

P

Seeded From UniProt

complete

PIG:TGBR3

involved_in

GO:0007165: signal transduction

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

PIG:TGBR3

involved_in

GO:0006955: immune response

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:Q03167

P

Seeded From UniProt

complete

PIG:TGBR3

involved_in

GO:0030509: BMP signaling pathway

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:Q03167

P

Seeded From UniProt

complete

PIG:TGBR3

located_in

GO:0062023: collagen-containing extracellular matrix

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

PIG:TGBR3

enables

GO:0005024: transforming growth factor beta-activated receptor activity

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:Q03167

F

Seeded From UniProt

complete

PIG:TGBR3

involved_in

GO:0051271: negative regulation of cellular component movement

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:Q03167

P

Seeded From UniProt

complete

PIG:TGBR3

enables

GO:0015026: coreceptor activity

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:Q03167

F

Seeded From UniProt

complete

PIG:TGBR3

enables

GO:0050431: transforming growth factor beta binding

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:Q03167

F

Seeded From UniProt

complete

PIG:TGBR3

enables

GO:0050431: transforming growth factor beta binding

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P26342

F

Seeded From UniProt

complete

PIG:TGBR3

enables

GO:0050431: transforming growth factor beta binding

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

PIG:TGBR3

enables

GO:0070123: transforming growth factor beta receptor activity, type III

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P26342

F

Seeded From UniProt

complete

PIG:TGBR3

involved_in

GO:0035556: intracellular signal transduction

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:Q03167

P

Seeded From UniProt

complete

HUMAN:TGBR3

enables

GO:0005160: transforming growth factor beta receptor binding

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P26342

F

Seeded From UniProt

complete

HUMAN:TGBR3

enables

GO:0005539: glycosaminoglycan binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:TGBR3

enables

GO:0008201: heparin binding

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P26342

F

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.