GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:TEP1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TEP1 (synonyms: TLP1, TP1) | |
| Protein Name(s) | Telomerase protein component 1
Telomerase-associated protein 1 Telomerase protein 1 p240 p80 telomerase homolog | |
| External Links | ||
| UniProt | Q99973 | |
| EMBL | U86136 BC126107 BX640983 | |
| CCDS | CCDS9548.1 | |
| RefSeq | NP_009041.2 XP_005268084.1 | |
| UniGene | Hs.508835 | |
| ProteinModelPortal | Q99973 | |
| SMR | Q99973 | |
| BioGrid | 112870 | |
| IntAct | Q99973 | |
| MINT | MINT-112815 | |
| STRING | 9606.ENSP00000262715 | |
| PhosphoSite | Q99973 | |
| DMDM | 215273899 | |
| MaxQB | Q99973 | |
| PaxDb | Q99973 | |
| PRIDE | Q99973 | |
| Ensembl | ENST00000262715 | |
| GeneID | 7011 | |
| KEGG | hsa:7011 | |
| UCSC | uc001vxe.3 | |
| CTD | 7011 | |
| GeneCards | GC14M020833 | |
| H-InvDB | HIX0026646 | |
| HGNC | HGNC:11726 | |
| HPA | HPA029206 | |
| MIM | 601686 | |
| neXtProt | NX_Q99973 | |
| PharmGKB | PA36443 | |
| eggNOG | COG2319 | |
| GeneTree | ENSGT00770000120592 | |
| HOGENOM | HOG000154545 | |
| HOVERGEN | HBG059633 | |
| InParanoid | Q99973 | |
| KO | K11127 | |
| OMA | LWHPLLV | |
| OrthoDB | EOG7W6WJT | |
| PhylomeDB | Q99973 | |
| TreeFam | TF328424 | |
| SignaLink | Q99973 | |
| ChiTaRS | TEP1 | |
| GeneWiki | TEP1 | |
| GenomeRNAi | 7011 | |
| NextBio | 27388 | |
| PRO | PR:Q99973 | |
| Proteomes | UP000005640 | |
| Bgee | Q99973 | |
| CleanEx | HS_TEP1 | |
| ExpressionAtlas | Q99973 | |
| Genevestigator | Q99973 | |
| GO | GO:0000781 GO:0005737 GO:0016363 GO:0030529 GO:0005697 GO:0005524 GO:0003723 GO:0006278 GO:0000722 | |
| Gene3D | 2.130.10.10 | |
| InterPro | IPR025139 IPR007111 IPR027417 IPR008850 IPR008858 IPR015943 IPR001680 IPR019775 IPR017986 | |
| Pfam | PF13271 PF05386 PF05731 PF00400 | |
| SMART | SM00320 | |
| SUPFAM | SSF50978 SSF52540 | |
| PROSITE | PS50837 PS51226 PS50988 PS00678 PS50082 PS50294 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0003723 |
RNA binding |
ECO:0000247 |
Ensembl:ENSMUSP00000006444
|
F |
In figure 2 the gel electrophoresis showed that there was more actin in muscle cells. |
complete | ||||
|
enables |
GO:0002039 |
p53 binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070034 |
telomerase RNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005697 |
telomerase holoenzyme complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0003720 |
telomerase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000722 |
telomere maintenance via recombination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016363 |
nuclear matrix |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006278 |
RNA-dependent DNA biosynthetic process |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003720 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006278 |
RNA-dependent DNA biosynthetic process |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0003720 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070034 |
telomerase RNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97499 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005697 |
telomerase holoenzyme complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97499 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97499 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003720 |
telomerase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97499 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1990904 |
ribonucleoprotein complex |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000781 |
chromosome, telomeric region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Harrington, L et al. (1997) A mammalian telomerase-associated protein. Science 275 973-7 PubMed GONUTS page
- ↑ Li, H et al. (1999) Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro. Oncogene 18 6785-94 PubMed GONUTS page
- ↑ Liu, Y et al. (2004) Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. Mol. Cell. Biol. 24 5314-23 PubMed GONUTS page
- ↑ 4.0 4.1 Chang, JT et al. (2002) Differential regulation of telomerase activity by six telomerase subunits. Eur. J. Biochem. 269 3442-50 PubMed GONUTS page
- ↑ Koyanagi, Y et al. () Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells. Anticancer Res. 20 773-8 PubMed GONUTS page
- ↑ 6.0 6.1 Joly, EC et al. (1994) TRiC-P5, a novel TCP1-related protein, is localized in the cytoplasm and in the nuclear matrix. J. Cell. Sci. 107 ( Pt 10) 2851-9 PubMed GONUTS page
- ↑ Poderycki, MJ et al. (2005) The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle. Nucleic Acids Res. 33 893-902 PubMed GONUTS page
c
r
t
