HUMAN:TEC

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TEC (synonyms: PSCTK4)
Protein Name(s)	Tyrosine-protein kinase Tec
External Links
UniProt	P42680
EMBL	D29767 CH471069 BC101711 BC101713 BC143487
CCDS	CCDS3481.1
PIR	I38268 I56997
RefSeq	NP_003206.2
UniGene	Hs.479670
PDB	2LUL
PDBsum	2LUL
ProteinModelPortal	P42680
SMR	P42680
BioGrid	112865
IntAct	P42680
MINT	MINT-1498364
STRING	9606.ENSP00000370912
BindingDB	P42680
ChEMBL	CHEMBL4246
GuidetoPHARMACOLOGY	2238
PhosphoSite	P42680
DMDM	158518392
MaxQB	P42680
PaxDb	P42680
PRIDE	P42680
DNASU	7006
Ensembl	ENST00000381501
GeneID	7006
KEGG	hsa:7006
UCSC	uc003gxz.3
CTD	7006
GeneCards	GC04M048137
HGNC	HGNC:11719
HPA	HPA005733
MIM	600583
neXtProt	NX_P42680
PharmGKB	PA36436
eggNOG	COG0515
GeneTree	ENSGT00760000119011
HOGENOM	HOG000233859
HOVERGEN	HBG008761
InParanoid	P42680
KO	K07364
OMA	TEFMERG
OrthoDB	EOG7KM5SC
PhylomeDB	P42680
TreeFam	TF351634
BRENDA	2.7.10.2
Reactome	REACT_111040 REACT_163834 REACT_23837
SignaLink	P42680
ChiTaRS	TEC
GeneWiki	TEC_(gene)
GenomeRNAi	7006
NextBio	27366
PRO	PR:P42680
Proteomes	UP000005640
Bgee	P42680
CleanEx	HS_TEC
ExpressionAtlas	P42680
Genevestigator	P42680
GO	GO:0005911 GO:0005856 GO:0005829 GO:0005886 GO:0005524 GO:0008289 GO:0046872 GO:0004715 GO:0050853 GO:0038095 GO:0045087 GO:0007229 GO:0035556 GO:0018108 GO:0006468 GO:0010543 GO:0042246
Gene3D	2.30.29.30 3.30.505.10
InterPro	IPR011009 IPR001849 IPR011993 IPR000719 IPR017441 IPR001245 IPR000980 IPR001452 IPR008266 IPR020635 IPR001562
Pfam	PF00779 PF00169 PF07714 PF00017 PF00018
PRINTS	PR00401 PR00452 PR00402 PR00109
SMART	SM00107 SM00233 SM00252 SM00326 SM00219
SUPFAM	SSF50044 SSF55550 SSF56112
PROSITE	PS50003 PS00107 PS50011 PS00109 PS50001 PS50002 PS51113

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:10518561^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q9ULZ2)	Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:10518561^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:10518561^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q9ULZ2)	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:10518561^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9ULZ2)	Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:10518561^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:10518561^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010543	regulation of platelet activation	PMID:9652744^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010543	regulation of platelet activation	PMID:9299487^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:9652744^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:9652744^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:9299487^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:10518561^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000700360 UniProtKB:P42680	P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102960 MGI:MGI:96621 PANTHER:PTN000700360	P		Seeded From UniProt	complete
involved_in	GO:0042246	tissue regeneration	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000700439 RGD:620973	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231474 UniProtKB:P42680	P		Seeded From UniProt	complete
involved_in	GO:0010543	regulation of platelet activation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000700439 UniProtKB:P42680	P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000700439 UniProtKB:P42680	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231474 UniProtKB:P42680 UniProtKB:P51813 UniProtKB:Q08881	F		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102960 MGI:MGI:96621 PANTHER:PTN000700360	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042246	tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2KA94 ensembl:ENSRNOP00000075313	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001562	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:7934162^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:7934162^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:7934162^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-512988	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-879914 Reactome:R-HSA-2730858 Reactome:R-HSA-2730847 Reactome:R-HSA-2730833 Reactome:R-HSA-205328	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Ohya, K et al. (1999) Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. Proc. Natl. Acad. Sci. U.S.A. 96 11976-81 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Hamazaki, Y et al. (1998) Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets. Oncogene 16 2773-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Laffargue, M et al. (1997) Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets. Biochem. Biophys. Res. Commun. 238 247-51 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Sato, K et al. (1994) Molecular cloning and analysis of the human Tec protein-tyrosine kinase. Leukemia 8 1663-72 PubMed GONUTS page

[PMID:10518561-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Ohya, K et al. (1999) Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. Proc. Natl. Acad. Sci. U.S.A. 96 11976-81 PubMed GONUTS page

[PMID:9652744-2] 2.0 ^2.1 ^2.2 Hamazaki, Y et al. (1998) Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets. Oncogene 16 2773-9 PubMed GONUTS page

[PMID:9299487-3] 3.0 ^3.1 Laffargue, M et al. (1997) Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets. Biochem. Biophys. Res. Commun. 238 247-51 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7934162-5] 5.0 ^5.1 ^5.2 Sato, K et al. (1994) Molecular cloning and analysis of the human Tec protein-tyrosine kinase. Leukemia 8 1663-72 PubMed GONUTS page

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HUMAN:TEC

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