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HUMAN:SYN1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SYN1
Protein Name(s) Synapsin-1

Brain protein 4.1 Synapsin I

External Links
UniProt P17600
EMBL M58378
M58321
M58341
M58351
M58353
M58359
M58371
M58372
M58373
M58374
M58375
M58376
M58377
M58378
M58321
M58341
M58351
M58353
M58359
M58371
M58372
M58373
M58374
M58375
M58376
M58377
AL009172
Z84466
AL009172
Z84466
Z84466
AL009172
Z84466
AL009172
CH471164
M55301
CCDS CCDS14280.1
CCDS35233.1
PIR A35363
RefSeq NP_008881.2
NP_598006.1
UniGene Hs.225936
ProteinModelPortal P17600
SMR P17600
BioGrid 112719
IntAct P17600
MINT MINT-1370745
STRING 9606.ENSP00000295987
PhosphoSite P17600
DMDM 73920800
MaxQB P17600
PaxDb P17600
PRIDE P17600
DNASU 6853
Ensembl ENST00000295987
ENST00000340666
GeneID 6853
KEGG hsa:6853
UCSC uc004did.3
uc004die.3
CTD 6853
GeneCards GC0XM047431
HGNC HGNC:11494
HPA CAB021929
HPA000397
MIM 300491
313440
neXtProt NX_P17600
Orphanet 85294
PharmGKB PA36276
eggNOG NOG284201
GeneTree ENSGT00530000063319
HOGENOM HOG000231323
HOVERGEN HBG016354
InParanoid P17600
OMA PIRQASQ
OrthoDB EOG793B7G
PhylomeDB P17600
TreeFam TF319919
Reactome REACT_15293
REACT_15425
ChiTaRS SYN1
GeneWiki Synapsin_I
GenomeRNAi 6853
NextBio 26745
PRO PR:P17600
Proteomes UP000005640
Bgee P17600
CleanEx HS_SYN1
Genevestigator P17600
GO GO:0030054
GO:0005829
GO:0030425
GO:0005794
GO:0008021
GO:0005524
GO:0003824
GO:0019901
GO:0005215
GO:0007269
GO:0046928
GO:2000300
GO:0007268
Gene3D 3.30.1490.20
3.30.470.20
3.40.50.20
InterPro IPR013815
IPR013816
IPR016185
IPR028713
IPR001359
IPR020898
IPR019735
IPR019736
IPR020897
PANTHER PTHR10841
PTHR10841:SF8
Pfam PF02078
PF02750
PF10581
PRINTS PR01368
SUPFAM SSF52440
PROSITE PS00415
PS00416

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005856

cytoskeleton

PMID:24327345[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:2000300

regulation of synaptic vesicle exocytosis

PMID:10099709[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88935

F

occurs_in:(UBERON:0000955)

Seeded From UniProt

complete

part_of

GO:0030672

synaptic vesicle membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103020
MGI:MGI:1351334
MGI:MGI:98460
PANTHER:PTN000851499

C

Seeded From UniProt

complete

involved_in

GO:0007269

neurotransmitter secretion

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103020
MGI:MGI:98460
PANTHER:PTN000851499

P

Seeded From UniProt

complete

involved_in

GO:0099504

synaptic vesicle cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88935
ensembl:ENSMUSP00000080568

P

Seeded From UniProt

complete

part_of

GO:0098793

presynapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88935
ensembl:ENSMUSP00000080568

C

Seeded From UniProt

complete

involved_in

GO:0098693

regulation of synaptic vesicle cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88935
ensembl:ENSMUSP00000080568

P

Seeded From UniProt

complete

part_of

GO:0098685

Schaffer collateral - CA1 synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88935
ensembl:ENSMUSP00000080568

C

Seeded From UniProt

complete

involved_in

GO:0097091

synaptic vesicle clustering

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88935
ensembl:ENSMUSP00000080568

P

Seeded From UniProt

complete

part_of

GO:0048786

presynaptic active zone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88935
ensembl:ENSMUSP00000080568

C

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88935
ensembl:ENSMUSP00000080568

C

Seeded From UniProt

complete

part_of

GO:0030672

synaptic vesicle membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88935
ensembl:ENSMUSP00000080568

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88935
ensembl:ENSMUSP00000080568

C

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88935
ensembl:ENSMUSP00000080568

F

Seeded From UniProt

complete

part_of

GO:0014069

postsynaptic density

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88935
ensembl:ENSMUSP00000080568

C

Seeded From UniProt

complete

involved_in

GO:0007269

neurotransmitter secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88935
ensembl:ENSMUSP00000080568

P

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88935
ensembl:ENSMUSP00000080568

C

Seeded From UniProt

complete

part_of

GO:0098993

anchored component of synaptic vesicle membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09951
ensembl:ENSRNOP00000014250

C

Seeded From UniProt

complete

part_of

GO:0098850

extrinsic component of synaptic vesicle membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09951
ensembl:ENSRNOP00000014250

C

Seeded From UniProt

complete

involved_in

GO:0050808

synapse organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09951
ensembl:ENSRNOP00000014250

P

Seeded From UniProt

complete

part_of

GO:0048786

presynaptic active zone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09951
ensembl:ENSRNOP00000014250

C

Seeded From UniProt

complete

involved_in

GO:0048666

neuron development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09951
ensembl:ENSRNOP00000014250

P

Seeded From UniProt

complete

enables

GO:0048306

calcium-dependent protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09951
ensembl:ENSRNOP00000014250

F

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09951
ensembl:ENSRNOP00000014250

C

Seeded From UniProt

complete

part_of

GO:0043229

intracellular organelle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09951
ensembl:ENSRNOP00000014250

C

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09951
ensembl:ENSRNOP00000014250

C

Seeded From UniProt

complete

part_of

GO:0008021

synaptic vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09951
ensembl:ENSRNOP00000014250

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09951
ensembl:ENSRNOP00000014250

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013815

F

Seeded From UniProt

complete

involved_in

GO:0007269

neurotransmitter secretion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001359
InterPro:IPR028713

P

Seeded From UniProt

complete

part_of

GO:0008021

synaptic vesicle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001359

C

Seeded From UniProt

complete

involved_in

GO:0046928

regulation of neurotransmitter secretion

PMID:21563316[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:15217342[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0008021

synaptic vesicle

PMID:16141272[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007268

chemical synaptic transmission

PMID:2110562[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005215

transporter activity

PMID:2110562[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0770
UniProtKB-SubCell:SL-0258

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Kaczmarski, W et al. (2014) Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). J. Neurosci. Res. 92 162-73 PubMed GONUTS page
  2. ↑ Fernández-Chacón, R & Südhof, TC (1999) Genetics of synaptic vesicle function: toward the complete functional anatomy of an organelle. Annu. Rev. Physiol. 61 753-76 PubMed GONUTS page
  3. ↑ 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Esposito, G et al. (2012) Synaptic vesicle trafficking and Parkinson's disease. Dev Neurobiol 72 134-44 PubMed GONUTS page
  5. ↑ Sudhof, TC (2004) The synaptic vesicle cycle. Annu. Rev. Neurosci. 27 509-47 PubMed GONUTS page
  6. ↑ Star, EN et al. (2005) Real-time imaging of Rab3a and Rab5a reveals differential roles in presynaptic function. J. Physiol. (Lond.) 569 103-17 PubMed GONUTS page
  7. ↑ 7.0 7.1 Südhof, TC (1990) The structure of the human synapsin I gene and protein. J. Biol. Chem. 265 7849-52 PubMed GONUTS page
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