GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:ST1E1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SULT1E1 (synonyms: STE) | |
| Protein Name(s) | Estrogen sulfotransferase
EST-1 Sulfotransferase 1E1 ST1E1 Sulfotransferase, estrogen-preferring | |
| External Links | ||
| UniProt | P49888 | |
| EMBL | U08098 U20521 U20515 U20516 U20517 U20518 U20519 U20520 S77383 Y11195 AY436634 BC027956 U55764 | |
| CCDS | CCDS3531.1 | |
| PIR | JC2229 | |
| RefSeq | NP_005411.1 | |
| UniGene | Hs.479898 | |
| PDB | 1G3M 1HY3 4JVL 4JVM 4JVN | |
| PDBsum | 1G3M 1HY3 4JVL 4JVM 4JVN | |
| ProteinModelPortal | P49888 | |
| SMR | P49888 | |
| BioGrid | 112660 | |
| IntAct | P49888 | |
| MINT | MINT-1368473 | |
| STRING | 9606.ENSP00000226444 | |
| BindingDB | P49888 | |
| ChEMBL | CHEMBL2346 | |
| DrugBank | DB00316 DB01176 | |
| PhosphoSite | P49888 | |
| DMDM | 1711604 | |
| MaxQB | P49888 | |
| PaxDb | P49888 | |
| PRIDE | P49888 | |
| Ensembl | ENST00000226444 | |
| GeneID | 6783 | |
| KEGG | hsa:6783 | |
| UCSC | uc003heo.3 | |
| CTD | 6783 | |
| GeneCards | GC04M070676 | |
| HGNC | HGNC:11377 | |
| HPA | CAB047344 HPA028213 HPA028728 | |
| MIM | 600043 | |
| neXtProt | NX_P49888 | |
| PharmGKB | PA340 | |
| eggNOG | NOG284811 | |
| HOGENOM | HOG000037209 | |
| HOVERGEN | HBG001195 | |
| InParanoid | P49888 | |
| KO | K01016 | |
| OMA | QMKESTL | |
| PhylomeDB | P49888 | |
| TreeFam | TF321745 | |
| BRENDA | 2.8.2.4 | |
| Reactome | REACT_6913 | |
| EvolutionaryTrace | P49888 | |
| GeneWiki | SULT1E1 | |
| GenomeRNAi | 6783 | |
| NextBio | 26488 | |
| PRO | PR:P49888 | |
| Proteomes | UP000005640 | |
| Bgee | P49888 | |
| CleanEx | HS_SULT1E1 | |
| ExpressionAtlas | P49888 | |
| Genevestigator | P49888 | |
| GO | GO:0005829 GO:0004304 GO:0047894 GO:0005496 GO:0050294 GO:0050427 GO:0008210 GO:0007565 GO:0044281 GO:0008202 GO:0051923 GO:0006805 | |
| Gene3D | 3.40.50.300 | |
| InterPro | IPR027417 IPR000863 | |
| Pfam | PF00685 | |
| SUPFAM | SSF52540 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006068 |
ethanol catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050427 |
3'-phosphoadenosine 5'-phosphosulfate metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051923 |
sulfation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006711 |
estrogen catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0045600 |
positive regulation of fat cell differentiation |
ECO:0000315 |
P |
Figure 2A and 2C show that preadipocytes in which SULT1E1 mRNA was overexpressed had higher rates of adipogenesis than the control preadipocytes with low levels of SULT1E1. |
complete | |||||
|
enables |
GO:0050294 |
steroid sulfotransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(CHEBI:16469) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045600 |
positive regulation of fat cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051923 |
sulfation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047894 |
flavonol 3-sulfotransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050294 |
steroid sulfotransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008210 |
estrogen metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051923 |
sulfation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008146 |
sulfotransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008146 |
sulfotransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004304 |
estrone sulfotransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008202 |
steroid metabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004304 |
estrone sulfotransferase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050427 |
3'-phosphoadenosine 5'-phosphosulfate metabolic process |
Reactome:R-HSA-156584 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-176664 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0005496 |
steroid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Kurogi, K et al. (2012) Ethanol sulfation by the human cytosolic sulfotransferases: a systematic analysis. Biol. Pharm. Bull. 35 2180-5 PubMed GONUTS page
- ↑ 2.0 2.1 Ihunnah, CA et al. (2014) Estrogen sulfotransferase/SULT1E1 promotes human adipogenesis. Mol. Cell. Biol. 34 1682-94 PubMed GONUTS page
- ↑ 3.0 3.1 Brand, W et al. (2010) Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples. Drug Metab. Dispos. 38 617-25 PubMed GONUTS page
- ↑ 4.0 4.1 Pedersen, LC et al. (2002) Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. J. Biol. Chem. 277 17928-32 PubMed GONUTS page
- ↑ 5.0 5.1 Senggunprai, L et al. (2009) Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases. Biochem. J. 422 455-62 PubMed GONUTS page
- ↑ 6.0 6.1 Aksoy, IA et al. (1994) Human liver estrogen sulfotransferase: identification by cDNA cloning and expression. Biochem. Biophys. Res. Commun. 200 1621-9 PubMed GONUTS page
e
s
