HUMAN:SRS10

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SRSF10 (synonyms: FUSIP1, FUSIP2, SFRS13A, TASR)
Protein Name(s)	Serine/arginine-rich splicing factor 10 40 kDa SR-repressor protein SRrp40 FUS-interacting serine-arginine-rich protein 1 Splicing factor SRp38 Splicing factor, arginine/serine-rich 13A TLS-associated protein with Ser-Arg repeats TASR TLS-associated protein with SR repeats TLS-associated serine-arginine protein TLS-associated SR protein
External Links
UniProt	O75494
EMBL	AF047448 AF067730 AF449427 AY150180 AY150181 AF419331 AF419332 AY048592 AY048592 AK001286 AK001656 AK296175 AL590609 AL590609 AL590609 AL590609 BC001107 BC005039 BC010074
CCDS	CCDS30629.1 CCDS30630.1 CCDS53280.1 CCDS53281.1 CCDS53282.1 CCDS53283.1
RefSeq	NP_001177934.1 NP_001177935.1 NP_001177936.1 NP_001177938.1 NP_006616.1 NP_473357.1
UniGene	Hs.3530
ProteinModelPortal	O75494
SMR	O75494
BioGrid	115990
IntAct	O75494
MINT	MINT-5002282
STRING	9606.ENSP00000420195
iPTMnet	O75494
PhosphoSitePlus	O75494
SwissPalm	O75494
BioMuta	SRSF10
EPD	O75494
MaxQB	O75494
PaxDb	O75494
PeptideAtlas	O75494
PRIDE	O75494
TopDownProteomics	O75494-1 O75494-2 O75494-3 O75494-4 O75494-5
DNASU	10772
Ensembl	ENST00000343255 ENST00000344989 ENST00000374452 ENST00000453840 ENST00000484146 ENST00000492112
GeneID	10772
KEGG	hsa:10772
UCSC	uc057dhz.1
CTD	10772
DisGeNET	10772
GeneCards	SRSF10
HGNC	HGNC:16713
HPA	HPA053805 HPA053831
MIM	605221
neXtProt	NX_O75494
OpenTargets	ENSG00000188529
PharmGKB	PA28427
eggNOG	KOG0118 COG0724
GeneTree	ENSGT00700000104403
HOGENOM	HOG000276233
HOVERGEN	HBG107480
InParanoid	O75494
KO	K12900
OMA	FAYVQYT
OrthoDB	EOG091G13K0
PhylomeDB	O75494
TreeFam	TF351864
Reactome	[www.reactome.org/content/detail/R-HSA-72163 R-HSA-72163]
GeneWiki	FUSIP1
GenomeRNAi	10772
PRO	PR:O75494
Proteomes	UP000005640
Bgee	ENSG00000188529
ExpressionAtlas	O75494
Genevisible	O75494
GO	GO:0005737 GO:0005829 GO:0016607 GO:0005654 GO:0005634 GO:0000166 GO:0003723 GO:0050733 GO:0051082 GO:0016482 GO:0006406 GO:0006376 GO:0000398 GO:0048025 GO:0048024 GO:0006355 GO:0000375 GO:0000244
Gene3D	3.30.70.330
InterPro	IPR012677 IPR000504 IPR034476
PANTHER	PTHR23147:SF34
Pfam	PF00076
SMART	SM00360
SUPFAM	SSF54928
PROSITE	PS50102

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0000375	RNA splicing, via transesterification reactions	PMID:27851963^[1]	ECO:0000314			P	Inhibitory effect on pre-mRNA splicing process.	complete CACAO 12859
involved_in	GO:0048024	regulation of mRNA splicing, via spliceosome	PMID:26876937^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	PMID:26876937^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:26876937^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	PMID:11684676^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0050733	RS domain binding	PMID:11684676^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0048025	negative regulation of mRNA splicing, via spliceosome	PMID:11684676^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22681889^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006376	mRNA splice site selection	PMID:9774382^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:9774382^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11684676^[3]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:11684676^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9774382^[6]	ECO:0000305	curator inference used in manual assertion	GO:0000398	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:9774382^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000398	mRNA splicing, via spliceosome	PMID:9774382^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000375	RNA splicing, via transesterification reactions	PMID:9774382^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000244	spliceosomal tri-snRNP complex assembly	PMID:11684676^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045292	mRNA cis splicing, via spliceosome	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260944 PANTHER:PTN000567445	P	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004587 FB:FBgn0265298 MGI:MGI:98283 MGI:MGI:98284 MGI:MGI:98285 MGI:MGI:98287 PANTHER:PTN000567445 RGD:1359422 TAIR:locus:2024770 TAIR:locus:2035651 TAIR:locus:2049766 TAIR:locus:2079502 TAIR:locus:2086804 TAIR:locus:2099931 TAIR:locus:2124799 TAIR:locus:2131864 TAIR:locus:2144945 TAIR:locus:2173338 TAIR:locus:2199837 UniProtKB:O75494 UniProtKB:P84103 UniProtKB:Q01130 UniProtKB:Q07955 UniProtKB:Q08170 UniProtKB:Q13247 UniProtKB:Q96PK6 UniProtKB:Q9BRL6 UniProtKB:Q9BWF3	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004587 FB:FBgn0011305 FB:FBgn0011640 FB:FBgn0028554 FB:FBgn0260944 FB:FBgn0265298 FB:FBgn0283477 MGI:MGI:1100865 MGI:MGI:1333805 MGI:MGI:1921361 MGI:MGI:98283 MGI:MGI:98284 MGI:MGI:98285 MGI:MGI:98287 PANTHER:PTN000567445 PomBase:SPBC11C11.08 RGD:1309233 RGD:1359241 RGD:1359422 RGD:1561347 RGD:1587490 RGD:3664 TAIR:locus:2024770 TAIR:locus:2035651 TAIR:locus:2046638 TAIR:locus:2049766 TAIR:locus:2079502 TAIR:locus:2086804 TAIR:locus:2099931 TAIR:locus:2114643 TAIR:locus:2117706 TAIR:locus:2119797 TAIR:locus:2122990 TAIR:locus:2124799 TAIR:locus:2131864 TAIR:locus:2144945 TAIR:locus:2173088 TAIR:locus:2173338 TAIR:locus:2199837 UniProtKB:O75494 UniProtKB:P84103 UniProtKB:Q01130 UniProtKB:Q07955 UniProtKB:Q08170 UniProtKB:Q13242 UniProtKB:Q13243 UniProtKB:Q13247 UniProtKB:Q16629 UniProtKB:Q8I3T5 UniProtKB:Q8I468 UniProtKB:Q96PK6 UniProtKB:Q9BQ04 UniProtKB:Q9BRL6 UniProtKB:Q9BWF3 UniProtKB:Q9Y4C8 WB:WBGene00004315 WB:WBGene00004699 WB:WBGene00004701 WB:WBGene00004703	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011640 PANTHER:PTN000567445 RGD:3664 SGD:S000001016 UniProtKB:O75494 UniProtKB:P84103 UniProtKB:Q07955 UniProtKB:Q13247 UniProtKB:Q9BWF3	F	Seeded From UniProt	complete
involved_in	GO:0000395	mRNA 5'-splice site recognition	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000567522 UniProtKB:Q8WXF0	P	Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004587 FB:FBgn0011305 FB:FBgn0028554 FB:FBgn0030479 FB:FBgn0260944 FB:FBgn0265298 FB:FBgn0283477 MGI:MGI:1100865 MGI:MGI:98284 PANTHER:PTN000567445 UniProtKB:P0DJD3 UniProtKB:Q13247 UniProtKB:Q8WXF0 UniProtKB:Q9BWF3	P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016482	C	Seeded From UniProt	complete
involved_in	GO:0048025	negative regulation of mRNA splicing, via spliceosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0U0 ensembl:ENSMUSP00000101479	P	Seeded From UniProt	complete
involved_in	GO:0016482	cytosolic transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0U0 ensembl:ENSMUSP00000101479	P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0U0 ensembl:ENSMUSP00000101479	C	Seeded From UniProt	complete
involved_in	GO:0000375	RNA splicing, via transesterification reactions	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0U0 ensembl:ENSMUSP00000101479	P	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000504 InterPro:IPR035979	F	Seeded From UniProt	complete
involved_in	GO:0043484	regulation of RNA splicing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034476	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0507	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0508	P	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0186	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Shkreta, L et al. (2016) SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors. Cell Rep 17 1990-2003 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Xiao, W et al. (2016) Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing. Mol. Cell 61 507-19 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Cowper, AE et al. (2001) Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. J. Biol. Chem. 276 48908-14 PubMed GONUTS page
↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Yang, L et al. (1998) Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. J. Biol. Chem. 273 27761-4 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:27851963-1] Shkreta, L et al. (2016) SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors. Cell Rep 17 1990-2003 PubMed GONUTS page

[PMID:26876937-2] 2.0 ^2.1 ^2.2 Xiao, W et al. (2016) Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing. Mol. Cell 61 507-19 PubMed GONUTS page

[PMID:11684676-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Cowper, AE et al. (2001) Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. J. Biol. Chem. 276 48908-14 PubMed GONUTS page

[PMID:22681889-4] Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page

[PMID:22658674-5] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:9774382-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Yang, L et al. (1998) Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. J. Biol. Chem. 273 27761-4 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:SRS10

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