HUMAN:SRPK2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SRPK2 (ECO:0000312 with EMBL:AAH68547.1)
Protein Name(s)	SRSF protein kinase 2 SFRS protein kinase 2 Serine/arginine-rich protein-specific kinase 2 SR-protein-specific kinase 2 SRSF protein kinase 2 N-terminal SRSF protein kinase 2 C-terminal
External Links
UniProt	P78362
EMBL	U88666 AC005070 AC005070 AC004884 AC073138 CH471070 BC035214 BC068547 BE781215 AY354201
CCDS	CCDS34724.1 CCDS5735.1
RefSeq	NP_001265202.1 NP_872633.1 NP_872634.1
UniGene	Hs.285197
PDB	2X7G
PDBsum	2X7G
ProteinModelPortal	P78362
SMR	P78362
BioGrid	112611
IntAct	P78362
MINT	MINT-1468300
STRING	9606.ENSP00000377262
BindingDB	P78362
ChEMBL	CHEMBL5668
DrugBank	DB00173
GuidetoPHARMACOLOGY	2209
iPTMnet	P78362
PhosphoSite	P78362
DMDM	300669676
MaxQB	P78362
PaxDb	P78362
PRIDE	P78362
DNASU	6733
Ensembl	ENST00000357311 ENST00000393651 ENST00000489828
GeneID	6733
KEGG	hsa:6733
UCSC	uc003vct.4 uc003vcv.4
CTD	6733
GeneCards	SRPK2
H-InvDB	HIX0006976
HGNC	HGNC:11306
HPA	HPA015522 HPA020876
MIM	602980
neXtProt	NX_P78362
PharmGKB	PA36130
eggNOG	KOG1290 ENOG410XRBH
GeneTree	ENSGT00530000063566
HOVERGEN	HBG108512
InParanoid	P78362
KO	K08831
OMA	PTWMESP
OrthoDB	EOG70S74X
PhylomeDB	P78362
TreeFam	TF105334
SignaLink	P78362
ChiTaRS	SRPK2
EvolutionaryTrace	P78362
GeneWiki	SRPK2
GenomeRNAi	6733
NextBio	26266
PRO	PR:P78362
Proteomes	UP000005640
Bgee	P78362
CleanEx	HS_SRPK2
ExpressionAtlas	P78362
Genevisible	P78362
GO	GO:0005737 GO:0005730 GO:0005654 GO:0005634 GO:0071889 GO:0005524 GO:0000287 GO:0044822 GO:0004674 GO:0001525 GO:0030154 GO:0045087 GO:0035556 GO:0045071 GO:0035063 GO:0045787 GO:0008284 GO:0010628 GO:0043525 GO:0045070 GO:0006468 GO:0048024 GO:0008380 GO:0000245
InterPro	IPR011009 IPR000719 IPR017441 IPR008271
Pfam	PF00069
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0071889	14-3-3 protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54781	F	Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54781	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:12417631^[1]	ECO:0000305	curator inference used in manual assertion	GO:0045071	P	Seeded From UniProt	complete
involved_in	GO:0045071	negative regulation of viral genome replication	PMID:12417631^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045070	positive regulation of viral genome replication	PMID:20498328^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54781	P	Seeded From UniProt	complete
involved_in	GO:0035063	nuclear speck organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54781	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54781	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:18559500^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54781	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22681889^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:9472028^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	PMID:9472028^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9472028^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9472028^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9472028^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:9472028^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9472028^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	PMID:9472028^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000245	spliceosomal complex assembly	PMID:9472028^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050684	regulation of mRNA processing	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 PANTHER:PTN000622883 UniProtKB:Q96SB4	P	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1346865 PANTHER:PTN000622075 RGD:3046 RGD:70500 RGD:71050 UniProtKB:P78362 UniProtKB:Q16539 UniProtKB:Q96SB4 UniProtKB:Q9UPZ9 WB:WBGene00004055 WB:WBGene00004056	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346861 PANTHER:PTN000622075 UniProtKB:A9T142	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0052703 FB:FBgn0267339 MGI:MGI:1201408 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346862 MGI:MGI:1346863 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:2444559 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:621506 RGD:628847 RGD:70500 RGD:70975 RGD:71050 SGD:S000000112 SGD:S000004103 SGD:S000004829 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P28482 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q96SB4 WB:WBGene00002178 WB:WBGene00002187 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004056 WB:WBGene00004057	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003256 FB:FBgn0015765 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1336881 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:1934157 MGI:MGI:2444559 MGI:MGI:96913 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPAC31G5.09c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:3663 RGD:621505 RGD:621506 RGD:628675 RGD:628847 RGD:70496 RGD:70500 SGD:S000000112 SGD:S000001072 SGD:S000003272 SGD:S000003642 SGD:S000004103 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P20794 UniProtKB:P28482 UniProtKB:P45983 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q5AZN7 UniProtKB:Q8GYQ5 UniProtKB:Q96SB4 UniProtKB:Q9LV37 UniProtKB:Q9P419 WB:WBGene00002178 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004057 dictyBase:DDB_G0283903 dictyBase:DDB_G0286353	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201408 MGI:MGI:1891338 PANTHER:PTN000622883 PomBase:SPBC530.14c SGD:S000004829 UniProtKB:A0A0B4KF69 UniProtKB:O77306 UniProtKB:P78362 UniProtKB:Q96SB4 WB:WBGene00004980	F	Seeded From UniProt	complete
involved_in	GO:0000245	spliceosomal complex assembly	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1201408 PANTHER:PTN000622883 UniProtKB:P78362	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P	Seeded From UniProt	complete
	GO:0004674	protein serine/threonine kinase activity	PMID:26167880^[8]	ECO:0000316		UniProtKB:Q15637	F	Figure 5b shows phosphorylation of SF1 by srpk2 in a western blot.	complete CACAO 11251
involved_in	GO:0048024	regulation of mRNA splicing, via spliceosome	PMID:21205200^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
	GO:0018105	peptidyl-serine phosphorylation	PMID:26167880^[8]	ECO:0000316		UniProtKB:Q15637	P	Figure 5b shows phosphorylation of SF1 by srpk2 in a western blot.	complete CACAO 11265
involved_in	GO:0006397	mRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0507	P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0508	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kamachi, M et al. (2002) Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway. J. Exp. Med. 196 1213-25 PubMed GONUTS page
↑ Karakama, Y et al. (2010) Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Antimicrob. Agents Chemother. 54 3179-86 PubMed GONUTS page
↑ Jang, SW et al. (2008) Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1. Cancer Res. 68 4559-70 PubMed GONUTS page
↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Wang, HY et al. (1998) SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. J. Cell Biol. 140 737-50 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 Lipp, JJ et al. (2015) SR protein kinases promote splicing of nonconsensus introns. Nat. Struct. Mol. Biol. 22 611-7 PubMed GONUTS page
↑ Giannakouros, T et al. (2011) Serine-arginine protein kinases: a small protein kinase family with a large cellular presence. FEBS J. 278 570-86 PubMed GONUTS page

[PMID:12417631-1] 1.0 ^1.1 Kamachi, M et al. (2002) Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway. J. Exp. Med. 196 1213-25 PubMed GONUTS page

[PMID:20498328-2] Karakama, Y et al. (2010) Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Antimicrob. Agents Chemother. 54 3179-86 PubMed GONUTS page

[PMID:18559500-3] Jang, SW et al. (2008) Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1. Cancer Res. 68 4559-70 PubMed GONUTS page

[PMID:22681889-4] Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page

[PMID:22658674-5] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:9472028-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Wang, HY et al. (1998) SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. J. Cell Biol. 140 737-50 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26167880-8] 8.0 ^8.1 Lipp, JJ et al. (2015) SR protein kinases promote splicing of nonconsensus introns. Nat. Struct. Mol. Biol. 22 611-7 PubMed GONUTS page

[PMID:21205200-9] Giannakouros, T et al. (2011) Serine-arginine protein kinases: a small protein kinase family with a large cellular presence. FEBS J. 278 570-86 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

HUMAN:SRPK2

Contents

Annotations

Notes

References

1

a

c

e

h

i

k

m

n

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools