HUMAN:SPB6

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SERPINB6 (synonyms: PI6, PTI)
Protein Name(s)	Serpin B6 Cytoplasmic antiproteinase CAP Peptidase inhibitor 6 PI-6 Placental thrombin inhibitor
External Links
UniProt	P35237
EMBL	Z22658 S69272 AK314578 BX538343 AL133351 CH471087 BC001394 BC098564 AB209563
CCDS	CCDS4479.1
PIR	A48681
RefSeq	NP_001182220.2 NP_001258751.1 NP_001258752.1 NP_001258753.1 NP_001258754.1 NP_001284628.1 NP_001284629.1 NP_004559.4
UniGene	Hs.519523 Hs.731506
ProteinModelPortal	P35237
SMR	P35237
BioGrid	111287
IntAct	P35237
MINT	MINT-5005332
STRING	9606.ENSP00000338358
DrugBank	DB00055
MEROPS	I04.011
PhosphoSite	P35237
DMDM	161784343
OGP	P35237
MaxQB	P35237
PaxDb	P35237
PRIDE	P35237
DNASU	5269
Ensembl	ENST00000335686 ENST00000380520 ENST00000380524 ENST00000380529 ENST00000380539 ENST00000380546
GeneID	5269
KEGG	hsa:5269
UCSC	uc003muk.3
CTD	5269
GeneCards	GC06M002948
H-InvDB	HIX0005534
HGNC	HGNC:8950
HPA	HPA009668 HPA012736
MIM	173321 613453
neXtProt	NX_P35237
Orphanet	90636
PharmGKB	PA35516
eggNOG	COG4826
GeneTree	ENSGT00760000118789
HOGENOM	HOG000238519
HOVERGEN	HBG005957
InParanoid	P35237
KO	K13963
OMA	FDKENTE
OrthoDB	EOG7327PB
PhylomeDB	P35237
TreeFam	TF352619
Reactome	REACT_641
ChiTaRS	SERPINB6
GeneWiki	SERPINB6
GenomeRNAi	5269
NextBio	20356
PRO	PR:P35237
Proteomes	UP000005640
Bgee	P35237
CleanEx	HS_SERPINB6
ExpressionAtlas	P35237
Genevestigator	P35237
GO	GO:0005737 GO:0005829 GO:0005615 GO:0070062 GO:0043234 GO:0002020 GO:0004867 GO:0010951 GO:0030162
InterPro	IPR023795 IPR023796 IPR000215
PANTHER	PTHR11461
Pfam	PF00079
SMART	SM00093
SUPFAM	SSF56574
PROSITE	PS00284

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28344315^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002371)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28675934^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0003688)	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:27068509^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:14670919^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20231	F	occurs_in:(CL:0000097)	Seeded From UniProt	complete
NOT\|part_of	GO:0005634	nucleus	PMID:14670919^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14670919^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000097)\|part_of:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0071470	cellular response to osmotic stress	PMID:20451170^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	PMID:20451170^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0097180	serine protease inhibitor complex	PMID:17761692^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	PMID:17761692^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:17761692^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:17761692^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60259	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17761692^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20451170^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028988 FB:FBgn0265137 PANTHER:PTN000156123 RGD:3249 UniProtKB:P05121 UniProtKB:P29508 UniProtKB:P35237 UniProtKB:P50452 UniProtKB:P50453 UniProtKB:Q9UIV8	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103123 MGI:MGI:106603 PANTHER:PTN000156767 UniProtKB:P35237 UniProtKB:P50453	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002930 FB:FBgn0015586 FB:FBgn0028986 FB:FBgn0031973 FB:FBgn0262057 FB:FBgn0265137 MGI:MGI:108080 MGI:MGI:1915304 MGI:MGI:87963 MGI:MGI:88278 MGI:MGI:894696 PANTHER:PTN000156123 RGD:1306692 RGD:1307404 RGD:2069 RGD:3249 RGD:3326 RGD:3747 RGD:3748 RGD:619833 RGD:631369 RGD:735225 UniProtKB:P01008 UniProtKB:P01009 UniProtKB:P01011 UniProtKB:P01019 UniProtKB:P05121 UniProtKB:P05154 UniProtKB:P08697 UniProtKB:P50453 UniProtKB:Q90935 UniProtKB:Q99574 UniProtKB:Q9TTE1	C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002930 FB:FBgn0028983 FB:FBgn0028988 FB:FBgn0028990 FB:FBgn0265137 MGI:MGI:101780 MGI:MGI:106603 MGI:MGI:1277952 MGI:MGI:2445361 MGI:MGI:2683293 MGI:MGI:891970 MGI:MGI:894696 MGI:MGI:97608 PANTHER:PTN000156123 RGD:1306692 RGD:1307404 RGD:3249 RGD:3326 RGD:3748 RGD:619817 RGD:619896 RGD:619897 UniProtKB:P01009 UniProtKB:P01012 UniProtKB:P05121 UniProtKB:P05154 UniProtKB:P05155 UniProtKB:P07093 UniProtKB:P08697 UniProtKB:P35237 UniProtKB:P48594 UniProtKB:P50452 UniProtKB:P50453 UniProtKB:Q3ZEJ6 UniProtKB:Q86WD7 UniProtKB:Q90935 UniProtKB:Q96P63 UniProtKB:Q99574 UniProtKB:Q9TTE1 UniProtKB:Q9UIV8 WB:WBGene00005643	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000215	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:8415716^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:8415716^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0101003	ficolin-1-rich granule membrane	Reactome:R-HSA-6800426	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070821	tertiary granule membrane	Reactome:R-HSA-6798747	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	Reactome:R-HSA-6798743	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-6800426 Reactome:R-HSA-6798747 Reactome:R-HSA-6798743	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010466	negative regulation of peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	P		Seeded From UniProt	complete
enables	GO:0030414	peptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	F		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0722	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page
↑ Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Strik, MC et al. (2004) Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers. Blood 103 2710-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Sirmaci, A et al. (2010) A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss. Am. J. Hum. Genet. 86 797-804 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Scott, FL et al. (2007) SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes. J. Biochem. 142 435-42 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 Coughlin, P et al. (1993) Cloning and molecular characterization of a human intracellular serine proteinase inhibitor. Proc. Natl. Acad. Sci. U.S.A. 90 9417-21 PubMed GONUTS page

[PMID:28344315-1] Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page

[PMID:28675934-2] Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page

[PMID:27068509-3] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:14670919-4] 4.0 ^4.1 ^4.2 Strik, MC et al. (2004) Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers. Blood 103 2710-7 PubMed GONUTS page

[PMID:20451170-5] 5.0 ^5.1 ^5.2 Sirmaci, A et al. (2010) A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss. Am. J. Hum. Genet. 86 797-804 PubMed GONUTS page

[PMID:23533145-6] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19056867-7] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:17761692-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Scott, FL et al. (2007) SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes. J. Biochem. 142 435-42 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8415716-10] 10.0 ^10.1 Coughlin, P et al. (1993) Cloning and molecular characterization of a human intracellular serine proteinase inhibitor. Proc. Natl. Acad. Sci. U.S.A. 90 9417-21 PubMed GONUTS page

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HUMAN:SPB6

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