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HUMAN:SPB6

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SERPINB6 (synonyms: PI6, PTI)
Protein Name(s) Serpin B6

Cytoplasmic antiproteinase CAP Peptidase inhibitor 6 PI-6 Placental thrombin inhibitor

External Links
UniProt P35237
EMBL Z22658
S69272
AK314578
BX538343
AL133351
CH471087
BC001394
BC098564
AB209563
CCDS CCDS4479.1
PIR A48681
RefSeq NP_001182220.2
NP_001258751.1
NP_001258752.1
NP_001258753.1
NP_001258754.1
NP_001284628.1
NP_001284629.1
NP_004559.4
UniGene Hs.519523
Hs.731506
ProteinModelPortal P35237
SMR P35237
BioGrid 111287
IntAct P35237
MINT MINT-5005332
STRING 9606.ENSP00000338358
DrugBank DB00055
MEROPS I04.011
PhosphoSite P35237
DMDM 161784343
OGP P35237
MaxQB P35237
PaxDb P35237
PRIDE P35237
DNASU 5269
Ensembl ENST00000335686
ENST00000380520
ENST00000380524
ENST00000380529
ENST00000380539
ENST00000380546
GeneID 5269
KEGG hsa:5269
UCSC uc003muk.3
CTD 5269
GeneCards GC06M002948
H-InvDB HIX0005534
HGNC HGNC:8950
HPA HPA009668
HPA012736
MIM 173321
613453
neXtProt NX_P35237
Orphanet 90636
PharmGKB PA35516
eggNOG COG4826
GeneTree ENSGT00760000118789
HOGENOM HOG000238519
HOVERGEN HBG005957
InParanoid P35237
KO K13963
OMA FDKENTE
OrthoDB EOG7327PB
PhylomeDB P35237
TreeFam TF352619
Reactome REACT_641
ChiTaRS SERPINB6
GeneWiki SERPINB6
GenomeRNAi 5269
NextBio 20356
PRO PR:P35237
Proteomes UP000005640
Bgee P35237
CleanEx HS_SERPINB6
ExpressionAtlas P35237
Genevestigator P35237
GO GO:0005737
GO:0005829
GO:0005615
GO:0070062
GO:0043234
GO:0002020
GO:0004867
GO:0010951
GO:0030162
InterPro IPR023795
IPR023796
IPR000215
PANTHER PTHR11461
Pfam PF00079
SMART SM00093
SUPFAM SSF56574
PROSITE PS00284

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28344315[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0002371)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28675934[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0003688)

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:27068509[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0007318)

Seeded From UniProt

complete

enables

GO:0002020

protease binding

PMID:14670919[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P20231

F

occurs_in:(CL:0000097)

Seeded From UniProt

complete

NOT|part_of

GO:0005634

nucleus

PMID:14670919[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:14670919[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000097)|part_of:(CL:0000235)

Seeded From UniProt

complete

involved_in

GO:0071470

cellular response to osmotic stress

PMID:20451170[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

PMID:20451170[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0097180

serine protease inhibitor complex

PMID:17761692[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010951

negative regulation of endopeptidase activity

PMID:17761692[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004867

serine-type endopeptidase inhibitor activity

PMID:17761692[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0002020

protease binding

PMID:17761692[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O60259

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:17761692[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:20451170[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010951

negative regulation of endopeptidase activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0028988
FB:FBgn0265137
PANTHER:PTN000156123
RGD:3249
UniProtKB:P05121
UniProtKB:P29508
UniProtKB:P35237
UniProtKB:P50452
UniProtKB:P50453
UniProtKB:Q9UIV8

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103123
MGI:MGI:106603
PANTHER:PTN000156767
UniProtKB:P35237
UniProtKB:P50453

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002930
FB:FBgn0015586
FB:FBgn0028986
FB:FBgn0031973
FB:FBgn0262057
FB:FBgn0265137
MGI:MGI:108080
MGI:MGI:1915304
MGI:MGI:87963
MGI:MGI:88278
MGI:MGI:894696
PANTHER:PTN000156123
RGD:1306692
RGD:1307404
RGD:2069
RGD:3249
RGD:3326
RGD:3747
RGD:3748
RGD:619833
RGD:631369
RGD:735225
UniProtKB:P01008
UniProtKB:P01009
UniProtKB:P01011
UniProtKB:P01019
UniProtKB:P05121
UniProtKB:P05154
UniProtKB:P08697
UniProtKB:P50453
UniProtKB:Q90935
UniProtKB:Q99574
UniProtKB:Q9TTE1

C

Seeded From UniProt

complete

enables

GO:0004867

serine-type endopeptidase inhibitor activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002930
FB:FBgn0028983
FB:FBgn0028988
FB:FBgn0028990
FB:FBgn0265137
MGI:MGI:101780
MGI:MGI:106603
MGI:MGI:1277952
MGI:MGI:2445361
MGI:MGI:2683293
MGI:MGI:891970
MGI:MGI:894696
MGI:MGI:97608
PANTHER:PTN000156123
RGD:1306692
RGD:1307404
RGD:3249
RGD:3326
RGD:3748
RGD:619817
RGD:619896
RGD:619897
UniProtKB:P01009
UniProtKB:P01012
UniProtKB:P05121
UniProtKB:P05154
UniProtKB:P05155
UniProtKB:P07093
UniProtKB:P08697
UniProtKB:P35237
UniProtKB:P48594
UniProtKB:P50452
UniProtKB:P50453
UniProtKB:Q3ZEJ6
UniProtKB:Q86WD7
UniProtKB:Q90935
UniProtKB:Q96P63
UniProtKB:Q99574
UniProtKB:Q9TTE1
UniProtKB:Q9UIV8
WB:WBGene00005643

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000215

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:8415716[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004867

serine-type endopeptidase inhibitor activity

PMID:8415716[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0101003

ficolin-1-rich granule membrane

Reactome:R-HSA-6800426

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070821

tertiary granule membrane

Reactome:R-HSA-6798747

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030667

secretory granule membrane

Reactome:R-HSA-6798743

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-6800426
Reactome:R-HSA-6798747
Reactome:R-HSA-6798743

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0010466

negative regulation of peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0646

P

Seeded From UniProt

complete

enables

GO:0030414

peptidase inhibitor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0646

F

Seeded From UniProt

complete

enables

GO:0004867

serine-type endopeptidase inhibitor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0722

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page
  2. Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
  3. Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
  4. 4.0 4.1 4.2 Strik, MC et al. (2004) Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers. Blood 103 2710-7 PubMed GONUTS page
  5. 5.0 5.1 5.2 Sirmaci, A et al. (2010) A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss. Am. J. Hum. Genet. 86 797-804 PubMed GONUTS page
  6. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  7. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 Scott, FL et al. (2007) SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes. J. Biochem. 142 435-42 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  10. 10.0 10.1 Coughlin, P et al. (1993) Cloning and molecular characterization of a human intracellular serine proteinase inhibitor. Proc. Natl. Acad. Sci. U.S.A. 90 9417-21 PubMed GONUTS page