HUMAN:SORL

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SORL1 (synonyms: C11orf32)
Protein Name(s)	Sortilin-related receptor Low-density lipoprotein receptor relative with 11 ligand-binding repeats LDLR relative with 11 ligand-binding repeats LR11 SorLA-1 Sorting protein-related receptor containing LDLR class A repeats SorLA
External Links
UniProt	Q92673
EMBL	Y08110 U60975 AP000664 AP000977 CH471065 BC137171
CCDS	CCDS8436.1
RefSeq	NP_003096.1
UniGene	Hs.368592
PDB	2DM4 3G2S 3G2T
PDBsum	2DM4 3G2S 3G2T
ProteinModelPortal	Q92673
SMR	Q92673
BioGrid	112536
IntAct	Q92673
MINT	MINT-231252
STRING	9606.ENSP00000260197
PhosphoSite	Q92673
DMDM	296452912
MaxQB	Q92673
PaxDb	Q92673
PRIDE	Q92673
Ensembl	ENST00000260197
GeneID	6653
KEGG	hsa:6653
UCSC	uc001pxx.3
CTD	6653
GeneCards	GC11P121356
HGNC	HGNC:11185
HPA	CAB011500 HPA031321
MIM	104300 602005
neXtProt	NX_Q92673
Orphanet	1020
PharmGKB	PA36022
eggNOG	NOG281049
GeneTree	ENSGT00510000046443
HOGENOM	HOG000007009
HOVERGEN	HBG017830
InParanoid	Q92673
OMA	TNVYISS
OrthoDB	EOG7FV3PK
PhylomeDB	Q92673
TreeFam	TF324918
ChiTaRS	SORL1
EvolutionaryTrace	Q92673
GenomeRNAi	6653
NextBio	25935
PRO	PR:Q92673
Proteomes	UP000005640
Bgee	Q92673
CleanEx	HS_SORL1
ExpressionAtlas	Q92673
Genevestigator	Q92673
GO	GO:0005769 GO:0005783 GO:0005768 GO:0005615 GO:0070062 GO:0005794 GO:0031985 GO:0005887 GO:0034362 GO:0016020 GO:0005771 GO:0043025 GO:0005641 GO:0055037 GO:0005802 GO:0030306 GO:0001540 GO:0030169 GO:0004888 GO:0016477 GO:0008283 GO:0008203 GO:0006869 GO:1902960 GO:1902430 GO:0043407 GO:1902963 GO:1902997 GO:0050768 GO:1901215 GO:0032091 GO:0032460 GO:1902948 GO:1902771 GO:1902955 GO:2001137 GO:1902953 GO:0045732 GO:0070863 GO:1902966 GO:0006892 GO:0051604 GO:0045053 GO:0006605 GO:0000042 GO:0006622 GO:0006898 GO:0014910 GO:0007165
Gene3D	2.120.10.30 2.60.40.10 4.10.400.10
InterPro	IPR011042 IPR000742 IPR003961 IPR013783 IPR023415 IPR000033 IPR002172 IPR006581
Pfam	PF00041 PF00057 PF00058
PRINTS	PR00261
SMART	SM00181 SM00060 SM00192 SM00135 SM00602
SUPFAM	SSF49265 SSF57424
PROSITE	PS01186 PS50853 PS01209 PS50068 PS51120

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2001137	positive regulation of endocytic recycling	PMID:22621900^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P05067)	Seeded From UniProt	complete
involved_in	GO:1902997	negative regulation of neurofibrillary tangle assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88307	P		Seeded From UniProt	complete
involved_in	GO:1902966	positive regulation of protein localization to early endosome	PMID:22621900^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P05067)	Seeded From UniProt	complete
involved_in	GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process	PMID:17855360^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process	PMID:21989385^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	PMID:21989385^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	PMID:17855360^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	PMID:16407538^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902955	positive regulation of early endosome to recycling endosome transport	PMID:22621900^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P05067)	Seeded From UniProt	complete
involved_in	GO:1902953	positive regulation of ER to Golgi vesicle-mediated transport	PMID:17855360^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902948	negative regulation of tau-protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88307	P		Seeded From UniProt	complete
involved_in	GO:1902771	positive regulation of choline O-acetyltransferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88307	P		Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	PMID:24523320^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	PMID:24001769^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	PMID:17855360^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	PMID:21989385^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	PMID:22621900^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	PMID:16407538^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88307	P		Seeded From UniProt	complete
involved_in	GO:0070863	positive regulation of protein exit from endoplasmic reticulum	PMID:17855360^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	PMID:22621900^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051604	protein maturation	PMID:17855360^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P05067)	Seeded From UniProt	complete
involved_in	GO:0050768	negative regulation of neurogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88307	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:24523320^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045053	protein retention in Golgi apparatus	PMID:17855360^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88307	P		Seeded From UniProt	complete
involved_in	GO:0032460	negative regulation of protein oligomerization	PMID:21989385^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:16407538^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P56817) has_regulation_target:(UniProtKB:P05067)	Seeded From UniProt	complete
part_of	GO:0031985	Golgi cisterna	PMID:17855360^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030306	ADP-ribosylation factor binding	PMID:17855360^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UJY5	F		Seeded From UniProt	complete
involved_in	GO:0006892	post-Golgi vesicle-mediated transport	PMID:17855360^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006622	protein targeting to lysosome	PMID:24523320^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006605	protein targeting	PMID:16407538^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:24001769^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:17855360^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:22621900^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:24001769^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005641	nuclear envelope lumen	PMID:17855360^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005641	nuclear envelope lumen	PMID:21989385^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0005794)	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:16407538^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F	occurs_in:(GO:0005641)	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:24523320^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0034067	protein localization to Golgi apparatus	PMID:17855360^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P05067)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
enables	GO:0030169	low-density lipoprotein particle binding	PMID:17326667^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6Q788	F		Seeded From UniProt	complete
enables	GO:0030169	low-density lipoprotein particle binding	PMID:17326667^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02649	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:14764453^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0014910	regulation of smooth muscle cell migration	PMID:14764453^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006605	protein targeting	PMID:16174740^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:16174740^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:16174740^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:14764453^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902997	negative regulation of neurofibrillary tangle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88307 ensembl:ENSMUSP00000058613	P		Seeded From UniProt	complete
involved_in	GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88307 ensembl:ENSMUSP00000058613	P		Seeded From UniProt	complete
involved_in	GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88307 ensembl:ENSMUSP00000058613	P		Seeded From UniProt	complete
involved_in	GO:1902948	negative regulation of tau-protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88307 ensembl:ENSMUSP00000058613	P		Seeded From UniProt	complete
involved_in	GO:1902771	positive regulation of choline O-acetyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88307 ensembl:ENSMUSP00000058613	P		Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88307 ensembl:ENSMUSP00000058613	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88307 ensembl:ENSMUSP00000058613	P		Seeded From UniProt	complete
involved_in	GO:0050768	negative regulation of neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88307 ensembl:ENSMUSP00000058613	P		Seeded From UniProt	complete
involved_in	GO:0045053	protein retention in Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88307 ensembl:ENSMUSP00000058613	P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88307 ensembl:ENSMUSP00000058613	P		Seeded From UniProt	complete
part_of	GO:0005641	nuclear envelope lumen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88307 ensembl:ENSMUSP00000058613	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006581	C		Seeded From UniProt	complete
enables	GO:0005041	low-density lipoprotein particle receptor activity	PMID:20005821^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	PMID:9157966^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9157966^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	PMID:9157966^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	Reactome:R-HSA-8871506 Reactome:R-HSA-8871494	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	Reactome:R-HSA-8871506	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0445	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
part_of	GO:0034362	low-density lipoprotein particle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0427	C		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Herskowitz, JH et al. (2012) GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production. Mol. Biol. Cell 23 2645-57 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Schmidt, V et al. (2007) SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. J. Biol. Chem. 282 32956-64 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Schmidt, V et al. (2012) Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J. 31 187-200 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Spoelgen, R et al. (2006) Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J. Neurosci. 26 418-28 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Caglayan, S et al. (2014) Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation. Sci Transl Med 6 223ra20 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Burgert, T et al. (2013) SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes. Mol. Cell. Biol. 33 4308-20 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^8.0 ^8.1 Nilsson, SK et al. (2007) Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family. Biochemistry 46 3896-904 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Zhu, Y et al. (2004) LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration. Circ. Res. 94 752-8 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Andersen, OM et al. (2005) Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc. Natl. Acad. Sci. U.S.A. 102 13461-6 PubMed GONUTS page
↑ Kim, J et al. (2009) Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron 64 632-44 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Mörwald, S et al. (1997) A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens. Arterioscler. Thromb. Vasc. Biol. 17 996-1002 PubMed GONUTS page

[PMID:22621900-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Herskowitz, JH et al. (2012) GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production. Mol. Biol. Cell 23 2645-57 PubMed GONUTS page

[PMID:17855360-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Schmidt, V et al. (2007) SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. J. Biol. Chem. 282 32956-64 PubMed GONUTS page

[PMID:21989385-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Schmidt, V et al. (2012) Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J. 31 187-200 PubMed GONUTS page

[PMID:16407538-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Spoelgen, R et al. (2006) Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J. Neurosci. 26 418-28 PubMed GONUTS page

[PMID:24523320-5] 5.0 ^5.1 ^5.2 ^5.3 Caglayan, S et al. (2014) Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation. Sci Transl Med 6 223ra20 PubMed GONUTS page

[PMID:24001769-6] 6.0 ^6.1 ^6.2 Burgert, T et al. (2013) SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes. Mol. Cell. Biol. 33 4308-20 PubMed GONUTS page

[PMID:19056867-7] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:17326667-8] 8.0 ^8.1 Nilsson, SK et al. (2007) Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family. Biochemistry 46 3896-904 PubMed GONUTS page

[PMID:14764453-9] 9.0 ^9.1 ^9.2 Zhu, Y et al. (2004) LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration. Circ. Res. 94 752-8 PubMed GONUTS page

[PMID:16174740-10] 10.0 ^10.1 ^10.2 Andersen, OM et al. (2005) Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc. Natl. Acad. Sci. U.S.A. 102 13461-6 PubMed GONUTS page

[PMID:20005821-11] Kim, J et al. (2009) Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron 64 632-44 PubMed GONUTS page

[PMID:9157966-12] 12.0 ^12.1 ^12.2 Mörwald, S et al. (1997) A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens. Arterioscler. Thromb. Vasc. Biol. 17 996-1002 PubMed GONUTS page

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HUMAN:SORL

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