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HUMAN:SODM
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SOD2 | |
| Protein Name(s) | Superoxide dismutase [Mn], mitochondrial | |
| External Links | ||
| UniProt | P04179 | |
| EMBL | X59445 Y00472 Y00985 X07834 M36693 X15132 X14322 S77127 BT006967 AY267901 AK097395 AK296809 AK304766 AK313082 AL135914 CH471051 CH471051 BC012423 | |
| CCDS | CCDS34564.1 CCDS5265.1 | |
| PIR | S13162 | |
| RefSeq | NP_000627.2 NP_001019636.1 NP_001019637.1 | |
| UniGene | Hs.487046 | |
| PDB | 1AP5 1AP6 1EM1 1JA8 1LUV 1LUW 1MSD 1N0J 1N0N 1PL4 1PM9 1QNM 1SZX 1VAR 1XDC 1XIL 1ZSP 1ZTE 1ZUQ 2ADP 2ADQ 2GDS 2P4K 2QKA 2QKC 3C3S 3C3T | |
| PDBsum | 1AP5 1AP6 1EM1 1JA8 1LUV 1LUW 1MSD 1N0J 1N0N 1PL4 1PM9 1QNM 1SZX 1VAR 1XDC 1XIL 1ZSP 1ZTE 1ZUQ 2ADP 2ADQ 2GDS 2P4K 2QKA 2QKC 3C3S 3C3T | |
| ProteinModelPortal | P04179 | |
| SMR | P04179 | |
| BioGrid | 112531 | |
| IntAct | P04179 | |
| MINT | MINT-5002369 | |
| STRING | 9606.ENSP00000337127 | |
| Allergome | 784 | |
| PhosphoSite | P04179 | |
| DMDM | 134665 | |
| DOSAC-COBS-2DPAGE | P04179 | |
| OGP | P04179 | |
| SWISS-2DPAGE | P04179 | |
| UCD-2DPAGE | P04179 | |
| MaxQB | P04179 | |
| PaxDb | P04179 | |
| PRIDE | P04179 | |
| DNASU | 6648 | |
| Ensembl | ENST00000337404 ENST00000367054 ENST00000367055 ENST00000444946 ENST00000538183 ENST00000546087 | |
| GeneID | 6648 | |
| KEGG | hsa:6648 | |
| UCSC | uc003qsg.3 uc003qsh.3 uc011efu.1 | |
| CTD | 6648 | |
| GeneCards | GC06M160102 | |
| HGNC | HGNC:11180 | |
| HPA | CAB002013 HPA001814 | |
| MIM | 147460 612634 | |
| neXtProt | NX_P04179 | |
| PharmGKB | PA36017 | |
| eggNOG | COG0605 | |
| GeneTree | ENSGT00390000011877 | |
| HOGENOM | HOG000013583 | |
| HOVERGEN | HBG004451 | |
| InParanoid | P04179 | |
| KO | K04564 | |
| OrthoDB | EOG7FV3R5 | |
| PhylomeDB | P04179 | |
| TreeFam | TF105132 | |
| Reactome | REACT_172715 | |
| ChiTaRS | SOD2 | |
| EvolutionaryTrace | P04179 | |
| GeneWiki | SOD2 | |
| GenomeRNAi | 6648 | |
| NextBio | 25907 | |
| PRO | PR:P04179 | |
| Proteomes | UP000005640 | |
| Bgee | P04179 | |
| CleanEx | HS_SOD2 | |
| ExpressionAtlas | P04179 | |
| Genevestigator | P04179 | |
| GO | GO:0070062 GO:0005743 GO:0005759 GO:0042645 GO:0005739 GO:0003677 GO:0042802 GO:0030145 GO:0019825 GO:0004784 GO:0001315 GO:0071361 GO:0003032 GO:0048773 GO:0006749 GO:0007507 GO:0030097 GO:0050665 GO:0008630 GO:0008631 GO:0055072 GO:0001889 GO:0007626 GO:0008285 GO:0045599 GO:0048147 GO:0043524 GO:1902176 GO:0048666 GO:0032364 GO:0045429 GO:0009791 GO:0051289 GO:0008217 GO:0050790 GO:0051881 GO:0006357 GO:0001836 GO:0019430 GO:0022904 GO:0014823 GO:0048678 GO:0046686 GO:0009409 GO:0042493 GO:0051602 GO:0010332 GO:0042542 GO:0055093 GO:0001666 GO:0035902 GO:0035900 GO:0033591 GO:0032496 GO:0071000 GO:0010042 GO:0010269 GO:0034021 GO:0000303 GO:0010043 GO:0042554 GO:0006801 GO:0003069 | |
| InterPro | IPR001189 IPR019833 IPR019832 IPR019831 | |
| PANTHER | PTHR11404 | |
| Pfam | PF02777 PF00081 | |
| PIRSF | PIRSF000349 | |
| PRINTS | PR01703 | |
| SUPFAM | SSF46609 SSF54719 | |
| PROSITE | PS00088 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0010212 |
response to ionizing radiation |
ECO:0000315 |
P |
Reactive oxygen species harm the cell. SOD2 moderates this destruction. See Figure 3 & Table 1. |
complete | |||||
| GO:0050369 |
[tyrosine 3-monooxygenase] kinase activity |
ECO:0000314 |
F |
Fig. 1.Expression of human MnSOD in PC6 cells: localization to the mitochondria and protection against oxidative stress-induced apoptosis. |
complete | |||||
|
involved_in |
GO:1905932 |
positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0002591) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1905461 |
positive regulation of vascular associated smooth muscle cell apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0002591) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904706 |
negative regulation of vascular smooth muscle cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
results_in_division_of:(CL:0002591) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_o_results_in_movement_of:(CL:0002619) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902176 |
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0032364 |
oxygen homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019430 |
removal of superoxide radicals |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008217 |
regulation of blood pressure |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006801 |
superoxide metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004784 |
superoxide dismutase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0003069 |
acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001836 |
release of cytochrome c from mitochondria |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000303 |
response to superoxide |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051289 |
protein homotetramerization |
ECO:0000353 |
physical interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030145 |
manganese ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006801 |
superoxide metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004784 |
superoxide dismutase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004784 |
superoxide dismutase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001315 |
age-dependent response to reactive oxygen species |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000150074 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030145 |
manganese ion binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000150074 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98352 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004784 |
superoxide dismutase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98352 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004784 |
superoxide dismutase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001189 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006801 |
superoxide metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001189 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001189 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001189 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004784 |
superoxide dismutase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030145 |
manganese ion binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
PMID:10511315[16] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0035722 |
interleukin-12-mediated signaling pathway |
Reactome:R-HSA-9020591 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034599 |
cellular response to oxidative stress |
Reactome:R-HSA-3299685 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Hosoki, A et al. (2012) Mitochondria-targeted superoxide dismutase (SOD2) regulates radiation resistance and radiation stress response in HeLa cells. J. Radiat. Res. 53 58-71 PubMed GONUTS page
- ↑ Keller, JN et al. (1998) Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J. Neurosci. 18 687-97 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Zhang, Y & Xu, J (2016) MiR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression. Biochem. Biophys. Res. Commun. 473 342-348 PubMed GONUTS page
- ↑ Sánchez, E et al. (2013) LYRM7/MZM1L is a UQCRFS1 chaperone involved in the last steps of mitochondrial Complex III assembly in human cells. Biochim. Biophys. Acta 1827 285-93 PubMed GONUTS page
- ↑ Fleissner, F et al. (2010) Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism. Circ. Res. 107 138-43 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Pias, EK et al. (2003) Differential effects of superoxide dismutase isoform expression on hydroperoxide-induced apoptosis in PC-12 cells. J. Biol. Chem. 278 13294-301 PubMed GONUTS page
- ↑ Qi, X et al. (2007) Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis. Invest. Ophthalmol. Vis. Sci. 48 681-91 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Hu, Y et al. (2005) Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. J. Biol. Chem. 280 39485-92 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Perry, JJ et al. (2009) Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis. Biochemistry 48 3417-24 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Liang, LP & Patel, M (2004) Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice. Free Radic. Biol. Med. 36 542-54 PubMed GONUTS page
- ↑ Kiningham, KK & St Clair, DK (1997) Overexpression of manganese superoxide dismutase selectively modulates the activity of Jun-associated transcription factors in fibrosarcoma cells. Cancer Res. 57 5265-71 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Wang, J et al. (2011) Toward an understanding of the protein interaction network of the human liver. Mol. Syst. Biol. 7 536 PubMed GONUTS page
- ↑ Belikova, NA et al. (2009) Radioprotection by short-term oxidative preconditioning: role of manganese superoxide dismutase. FEBS Lett. 583 3437-42 PubMed GONUTS page
- ↑ 16.0 16.1 Melendez, JA et al. (1999) Nitric oxide enhances the manganese superoxide dismutase-dependent suppression of proliferation in HT-1080 fibrosarcoma cells. Cell Growth Differ. 10 655-64 PubMed GONUTS page
i
m
n
- GO:0008285 ! negative regulation of cell population proliferation
- GO:1902176 ! negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
- GO:0043524 ! negative regulation of neuron apoptotic process
- GO:1904706 ! negative regulation of vascular associated smooth muscle cell proliferation
o
p
- GO:0030335 ! positive regulation of cell migration
- GO:1905461 ! positive regulation of vascular associated smooth muscle cell apoptotic process
- GO:1905932 ! positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
- Primates
- GO:0051289 ! protein homotetramerization
r
