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PMID:9393747

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Citation

Kiningham, KK and St Clair, DK (1997) Overexpression of manganese superoxide dismutase selectively modulates the activity of Jun-associated transcription factors in fibrosarcoma cells. Cancer Res. 57:5265-71

Abstract

Manganese superoxide dismutase (MnSOD) is reduced in a variety of tumor cells and has been proposed to be a new type of tumor suppressor gene. The mechanism(s) by which MnSOD suppresses cancer development is currently unknown. However, expression of this antioxidant might play a significant role in maintaining cellular redox status. The relationship between MnSOD expression and modulation of DNA-binding activity and transcriptional activation of redox-sensitive oncoproteins and tumor suppressor proteins was studied in a murine fibrosarcoma cell line (FSa-II). Electrophoretic mobility shift assay and transcriptional activation studies revealed an inverse correlation between MnSOD expression and activity of c-jun-associated transcription factors, activator protein 1 and cyclic AMP-responsive element binding protein. Furthermore, expression of an activator protein 1 target gene, bcl-xL, was decreased in MnSOD-transfected cell lines. The results suggest that overexpression of MnSOD may exert its tumor suppressor activity, in part, by modulation of specific oncogenes.

Links

PubMed

Keywords

Animals; Clone Cells; Cyclic AMP Response Element-Binding Protein/metabolism; Fibrosarcoma/metabolism; Genes, Tumor Suppressor; Luciferases/biosynthesis; Mice; Proto-Oncogene Proteins c-bcl-2/metabolism; Proto-Oncogene Proteins c-jun/metabolism; Recombinant Fusion Proteins/biosynthesis; Superoxide Dismutase/biosynthesis; Transcription Factor AP-1/metabolism; Transcription Factors/metabolism; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tumor Stem Cell Assay; bcl-X Protein

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:SODM

involved_in

GO:0006357: regulation of transcription by RNA polymerase II

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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