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HUMAN:SOCS3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SOCS3 (synonyms: CIS3, SSI3)
Protein Name(s) Suppressor of cytokine signaling 3

SOCS-3 Cytokine-inducible SH2 protein 3 CIS-3 STAT-induced STAT inhibitor 3 SSI-3

External Links
UniProt O14543
EMBL AB004904
AB006967
AF159854
BC060858
CCDS CCDS11756.1
PIR JC5627
JC5761
RefSeq NP_003946.3
UniGene Hs.527973
Hs.703620
ProteinModelPortal O14543
SMR O14543
BioGrid 114488
IntAct O14543
MINT MINT-149732
STRING 9606.ENSP00000330341
PhosphoSite O14543
PaxDb O14543
PRIDE O14543
DNASU 9021
Ensembl ENST00000330871
GeneID 9021
KEGG hsa:9021
UCSC uc002jvl.2
CTD 9021
GeneCards GC17M076352
HGNC HGNC:19391
HPA CAB012220
MIM 604176
neXtProt NX_O14543
PharmGKB PA134885765
eggNOG NOG281730
HOGENOM HOG000236320
HOVERGEN HBG105645
InParanoid O14543
KO K04696
OMA KRTYYIY
PhylomeDB O14543
TreeFam TF321368
Reactome REACT_111133
REACT_169118
REACT_24980
REACT_25078
REACT_25162
REACT_25216
REACT_27307
REACT_75842
SignaLink O14543
UniPathway UPA00143
ChiTaRS SOCS3
GeneWiki SOCS3
GenomeRNAi 9021
NextBio 33797
PRO PR:O14543
Proteomes UP000005640
Bgee O14543
CleanEx HS_SOCS3
ExpressionAtlas O14543
Genevestigator O14543
GO GO:0005829
GO:0004860
GO:0060670
GO:0019221
GO:0060333
GO:0007259
GO:0060397
GO:0043066
GO:0046627
GO:0006469
GO:0060674
GO:0045597
GO:0016567
GO:0040008
GO:0060334
GO:0060338
GO:0060708
GO:0060707
GO:0060337
Gene3D 3.30.505.10
InterPro IPR000980
IPR028413
IPR028414
IPR001496
PANTHER PTHR10385
PTHR10385:SF4
Pfam PF00017
PF07525
SMART SM00252
SM00253
SM00969
SUPFAM SSF55550
PROSITE PS50001
PS50225

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0046426

negative regulation of receptor signaling pathway via JAK-STAT

PMID:25019494[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042532

negative regulation of tyrosine phosphorylation of STAT protein

PMID:25019494[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046935

1-phosphatidylinositol-3-kinase regulator activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109277
PANTHER:PTN000806614
RGD:3329
RGD:621042

F

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0020622
PANTHER:PTN000806614
UniProtKB:P23727

P

Seeded From UniProt

complete

involved_in

GO:0046627

negative regulation of insulin receptor signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1201791
MGI:MGI:1354910
PANTHER:PTN000043896

P

Seeded From UniProt

complete

part_of

GO:0005942

phosphatidylinositol 3-kinase complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109277
PANTHER:PTN000806614
RGD:3329
UniProtKB:P23727
WB:WBGene00000001

C

Seeded From UniProt

complete

involved_in

GO:0006469

negative regulation of protein kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004860

P

Seeded From UniProt

complete

involved_in

GO:0043551

regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046935

P

Seeded From UniProt

complete

involved_in

GO:1990830

cellular response to leukemia inhibitory factor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35718
ensembl:ENSMUSP00000059129

P

Seeded From UniProt

complete

involved_in

GO:0060708

spongiotrophoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35718
ensembl:ENSMUSP00000059129

P

Seeded From UniProt

complete

involved_in

GO:0060707

trophoblast giant cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35718
ensembl:ENSMUSP00000059129

P

Seeded From UniProt

complete

involved_in

GO:0060674

placenta blood vessel development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35718
ensembl:ENSMUSP00000059129

P

Seeded From UniProt

complete

involved_in

GO:0060670

branching involved in labyrinthine layer morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35718
ensembl:ENSMUSP00000059129

P

Seeded From UniProt

complete

involved_in

GO:0050728

negative regulation of inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35718
ensembl:ENSMUSP00000059129

P

Seeded From UniProt

complete

involved_in

GO:0046627

negative regulation of insulin receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35718
ensembl:ENSMUSP00000059129

P

Seeded From UniProt

complete

involved_in

GO:0045597

positive regulation of cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35718
ensembl:ENSMUSP00000059129

P

Seeded From UniProt

complete

involved_in

GO:0045595

regulation of cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35718
ensembl:ENSMUSP00000059129

P

Seeded From UniProt

complete

involved_in

GO:0009968

negative regulation of signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35718
ensembl:ENSMUSP00000059129

P

Seeded From UniProt

complete

involved_in

GO:0001932

regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35718
ensembl:ENSMUSP00000059129

P

Seeded From UniProt

complete

enables

GO:0001784

phosphotyrosine residue binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35718
ensembl:ENSMUSP00000059129

F

Seeded From UniProt

complete

involved_in

GO:0007259

receptor signaling pathway via JAK-STAT

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028414

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR036036

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028414

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:9266833[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004860

protein kinase inhibitor activity

PMID:9266833[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070102

interleukin-6-mediated signaling pathway

Reactome:R-HSA-1059683

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060334

regulation of interferon-gamma-mediated signaling pathway

Reactome:R-HSA-877312

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043687

post-translational protein modification

Reactome:R-HSA-597592

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

Reactome:R-HSA-8849474

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

Reactome:R-HSA-6785807

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-NUL-1169195
Reactome:R-HSA-8956040
Reactome:R-HSA-8955289
Reactome:R-HSA-8955241
Reactome:R-HSA-8952044
Reactome:R-HSA-8952039
Reactome:R-HSA-8848178
Reactome:R-HSA-8848110
Reactome:R-HSA-877269
Reactome:R-HSA-6790041
Reactome:R-HSA-1112755

ECO:0000304

author statement supported by traceable reference used in manual assertion











C

Seeded From UniProt

complete

involved_in

GO:0040008

regulation of growth

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0341

P

Seeded From UniProt

complete

involved_in

GO:0009968

negative regulation of signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0734

P

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Xu, G et al. (2014) MiR-221 accentuates IFN׳s anti-HCV effect by downregulating SOCS1 and SOCS3. Virology 462-463 343-50 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 Minamoto, S et al. (1997) Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Biochem. Biophys. Res. Commun. 237 79-83 PubMed GONUTS page
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