HUMAN:SMRCD

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SMARCAD1 (synonyms: KIAA1122)
Protein Name(s)	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 ATP-dependent helicase 1 hHEL1
External Links
UniProt	Q9H4L7
EMBL	AY008271 AB032948 AK023990 AK027490 AK301668 AC096746 BC017953 BC045534 AL359929 AL512768
CCDS	CCDS3639.1 CCDS47101.1 CCDS58914.1
RefSeq	NP_001121901.1 NP_001121902.1 NP_001241878.1 NP_064544.2
UniGene	Hs.410406
ProteinModelPortal	Q9H4L7
SMR	Q9H4L7
BioGrid	121244
IntAct	Q9H4L7
STRING	9606.ENSP00000351947
PhosphoSite	Q9H4L7
DMDM	306526240
MaxQB	Q9H4L7
PaxDb	Q9H4L7
PRIDE	Q9H4L7
DNASU	56916
Ensembl	ENST00000354268 ENST00000359052 ENST00000457823 ENST00000509418
GeneID	56916
KEGG	hsa:56916
UCSC	uc003htb.4 uc003htc.4
CTD	56916
GeneCards	GC04P095128
H-InvDB	HIX0004380
HGNC	HGNC:18398
HPA	HPA016737
MIM	136000 612761
neXtProt	NX_Q9H4L7
Orphanet	289465
PharmGKB	PA134954731
eggNOG	COG0553
GeneTree	ENSGT00630000089890
HOGENOM	HOG000172362
HOVERGEN	HBG055804
InParanoid	Q9H4L7
KO	K14439
OMA	KNQRGIQ
OrthoDB	EOG7QNVKC
PhylomeDB	Q9H4L7
TreeFam	TF105768
ChiTaRS	SMARCAD1
GeneWiki	SMARCAD1
GenomeRNAi	56916
NextBio	62407
PRO	PR:Q9H4L7
Proteomes	UP000005640
Bgee	Q9H4L7
CleanEx	HS_SMARCAD1
ExpressionAtlas	Q9H4L7
Genevestigator	Q9H4L7
GO	GO:0000792 GO:0016363 GO:0043596 GO:0005634 GO:0035861 GO:0005524 GO:0003677 GO:0004386 GO:0003676 GO:0043044 GO:0016568 GO:0006338 GO:0051304 GO:0000729 GO:0070932 GO:0070933 GO:0009117 GO:0045893 GO:0051260 GO:0000018
Gene3D	3.40.50.300
InterPro	IPR003892 IPR014001 IPR001650 IPR027417 IPR000330
Pfam	PF00271 PF00176
SMART	SM00487 SM00490
SUPFAM	SSF52540
PROSITE	PS51140 PS51192 PS51194

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0070933	histone H4 deacetylation	PMID:21549307^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	PMID:21549307^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051304	chromosome separation	PMID:21549307^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:11031099^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11031099^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043596	nuclear replication fork	PMID:21549307^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043044	ATP-dependent chromatin remodeling	PMID:22960744^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:22960744^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	PMID:11031099^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	PMID:11031099^[2]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009117	nucleotide metabolic process	PMID:11031099^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:21549307^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:18675275^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	PMID:11031099^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04692	C	Seeded From UniProt	complete
involved_in	GO:0000729	DNA double-strand break processing	PMID:22960744^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000018	regulation of DNA recombination	PMID:11031099^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04692 ensembl:ENSMUSP00000031984	C	Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04692 ensembl:ENSMUSP00000031984	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000330	F	Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F	Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Rowbotham, SP et al. (2011) Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Mol. Cell 42 285-96 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Adra, CN et al. (2000) SMARCAD1, a novel human helicase family-defining member associated with genetic instability: cloning, expression, and mapping to 4q22-q23, a band rich in breakpoints and deletion mutants involved in several human diseases. Genomics 69 162-73 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Costelloe, T et al. (2012) The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection. Nature 489 581-4 PubMed GONUTS page
↑ Okazaki, N et al. (2008) The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS. J. Mol. Biol. 382 257-65 PubMed GONUTS page

[PMID:21549307-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Rowbotham, SP et al. (2011) Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Mol. Cell 42 285-96 PubMed GONUTS page

[PMID:11031099-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Adra, CN et al. (2000) SMARCAD1, a novel human helicase family-defining member associated with genetic instability: cloning, expression, and mapping to 4q22-q23, a band rich in breakpoints and deletion mutants involved in several human diseases. Genomics 69 162-73 PubMed GONUTS page

[PMID:22960744-3] 3.0 ^3.1 ^3.2 Costelloe, T et al. (2012) The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection. Nature 489 581-4 PubMed GONUTS page

[PMID:18675275-4] Okazaki, N et al. (2008) The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS. J. Mol. Biol. 382 257-65 PubMed GONUTS page

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HUMAN:SMRCD

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