HUMAN:SMO

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SMO (synonyms: SMOH)
Protein Name(s)	Smoothened homolog SMO Protein Gx
External Links
UniProt	Q99835
EMBL	U84401 AF114821 AF114819 AF114820 AF120103 AF071494 CH236950 CH471070 BC009989
CCDS	CCDS5811.1
RefSeq	NP_005622.1
UniGene	Hs.437846
PDB	4JKV 4N4W 4O9R 4QIM 4QIN
PDBsum	4JKV 4N4W 4O9R 4QIM 4QIN
ProteinModelPortal	Q99835
SMR	Q99835
BioGrid	112492
DIP	DIP-34574N
IntAct	Q99835
STRING	9606.ENSP00000249373
BindingDB	Q99835
ChEMBL	CHEMBL5971
DrugBank	DB01047 DB08828
GuidetoPHARMACOLOGY	239
PhosphoSite	Q99835
DMDM	6226142
PaxDb	Q99835
PRIDE	Q99835
DNASU	6608
Ensembl	ENST00000249373
GeneID	6608
KEGG	hsa:6608
UCSC	uc003vor.3
CTD	6608
GeneCards	GC07P128828
HGNC	HGNC:11119
HPA	CAB011446
MIM	601500
neXtProt	NX_Q99835
PharmGKB	PA35968
eggNOG	NOG312505
GeneTree	ENSGT00760000118864
HOGENOM	HOG000252964
HOVERGEN	HBG000352
InParanoid	Q99835
KO	K06226
OMA	KNSNRYP
OrthoDB	EOG74J972
PhylomeDB	Q99835
TreeFam	TF106460
Reactome	REACT_18372 REACT_267634
SignaLink	Q99835
ChiTaRS	SMO
GeneWiki	Smoothened
GenomeRNAi	6608
NextBio	25725
PRO	PR:Q99835
Proteomes	UP000005640
Bgee	Q99835
CleanEx	HS_SMO
ExpressionAtlas	Q99835
Genevestigator	Q99835
GO	GO:0060170 GO:0005929 GO:0005737 GO:0070062 GO:0016021 GO:0043231 GO:0043025 GO:0005886 GO:0072372 GO:0008144 GO:0004930 GO:0005113 GO:0030165 GO:0042813 GO:0017147 GO:0021984 GO:0009952 GO:0060413 GO:0048846 GO:0060070 GO:0010002 GO:0001708 GO:0071397 GO:0021953 GO:0021696 GO:0060830 GO:0060248 GO:0003140 GO:0007368 GO:0021904 GO:0031076 GO:0048557 GO:0048702 GO:0048703 GO:0060684 GO:0031017 GO:0021561 GO:0021508 GO:0048853 GO:0008406 GO:0031069 GO:0001947 GO:0003007 GO:0001701 GO:0060644 GO:0072285 GO:0007494 GO:0035264 GO:0042693 GO:0051451 GO:0043066 GO:0043392 GO:0030857 GO:0010629 GO:0051799 GO:0000122 GO:0001755 GO:0048663 GO:0031102 GO:0042475 GO:0001649 GO:0032474 GO:0061113 GO:0090190 GO:0050679 GO:0010628 GO:0007228 GO:0002053 GO:0002052 GO:0042307 GO:0045880 GO:0045944 GO:0034504 GO:0050821 GO:2000826 GO:2000036 GO:0072001 GO:0048752 GO:0048741 GO:0007224 GO:0021938 GO:0021910 GO:0061053 GO:0007283 GO:0021794 GO:0003323 GO:0001570 GO:0007371
Gene3D	1.10.2000.10
InterPro	IPR000539 IPR015526 IPR020067 IPR017981 IPR026544
PANTHER	PTHR11309 PTHR11309:SF35
Pfam	PF01534 PF01392
PRINTS	PR00489
SMART	SM00063
SUPFAM	SSF63501
PROSITE	PS50038 PS50261

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005929	cilium	PMID:19190184^[1]	ECO:0000270			C		Fig 3E. Smoothened (Smo) observed at the cilium.	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:21671467^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000100985)	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:21671467^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56726	C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:2000826	regulation of heart morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56726	P		Seeded From UniProt	complete
involved_in	GO:0071397	cellular response to cholesterol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56726	P		Seeded From UniProt	complete
involved_in	GO:0061053	somite development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56726	P		Seeded From UniProt	complete
involved_in	GO:0060248	detection of cell density by contact stimulus involved in contact inhibition	PMID:9422511^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048853	forebrain morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56726	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:11278759^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007494	midgut development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56726	P		Seeded From UniProt	complete
involved_in	GO:0007371	ventral midline determination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56726	P		Seeded From UniProt	complete
involved_in	GO:0007228	positive regulation of hh target transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56726	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:9422511^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005901	caveola	PMID:11278759^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005794	Golgi apparatus	PMID:11278759^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005113	patched binding	PMID:9811851^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13635	F		Seeded From UniProt	complete
enables	GO:0005113	patched binding	PMID:9811851^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y6C5	F		Seeded From UniProt	complete
involved_in	GO:0003140	determination of left/right asymmetry in lateral mesoderm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56726	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56726	P		Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56726	P		Seeded From UniProt	complete
involved_in	GO:0072285	mesenchymal to epithelial transition involved in metanephric renal vesicle formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56726	P		Seeded From UniProt	complete
involved_in	GO:0072001	renal system development	PMID:17850284^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043392	negative regulation of DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56726	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56726	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56726	P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:21177415^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:21177415^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:19304771^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:17850284^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19304771^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071679	commissural neuron axon guidance	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000885245 RGD:3726	P		Seeded From UniProt	complete
involved_in	GO:0045880	positive regulation of smoothened signaling pathway	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108075 PANTHER:PTN000885245	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003444 PANTHER:PTN000885245 RGD:3726	C		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108075 PANTHER:PTN000885245 ZFIN:ZDB-GENE-980526-89	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003444 MGI:MGI:108075 PANTHER:PTN000885245 UniProtKB:Q99835	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003444 MGI:MGI:108075 PANTHER:PTN000885245 ZFIN:ZDB-GENE-980526-89	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0016797 MGI:MGI:108075 MGI:MGI:108460 MGI:MGI:108476 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1313278 PANTHER:PTN000139394 RGD:61916 RGD:628817 RGD:71012 UniProtKB:O00144 UniProtKB:O19116 UniProtKB:O60353 UniProtKB:O75084 UniProtKB:Q14332 UniProtKB:Q99835 UniProtKB:Q9NPG1 UniProtKB:Q9ULV1 WB:WBGene00003006 ZFIN:ZDB-GENE-990415-223	C		Seeded From UniProt	complete
enables	GO:0005113	patched binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000885245 UniProtKB:Q99835	F		Seeded From UniProt	complete
involved_in	GO:2000826	regulation of heart morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:2000036	regulation of stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0072285	mesenchymal to epithelial transition involved in metanephric renal vesicle formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0071397	cellular response to cholesterol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0070986	left/right axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0061113	pancreas morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0061053	somite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0060684	epithelial-mesenchymal cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0060644	mammary gland epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0060413	atrial septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	C		Seeded From UniProt	complete
involved_in	GO:0051799	negative regulation of hair follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0051451	myoblast migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0048873	homeostasis of number of cells within a tissue	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0048853	forebrain morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0048741	skeletal muscle fiber development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0048589	developmental growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0048468	cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0048143	astrocyte activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0046622	positive regulation of organ growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0045880	positive regulation of smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0043392	negative regulation of DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0040018	positive regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0035264	multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0031069	hair follicle morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0030857	negative regulation of epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0021953	central nervous system neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0021904	dorsal/ventral neural tube patterning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0021794	thalamus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0021696	cerebellar cortex morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0021542	dentate gyrus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	F		Seeded From UniProt	complete
involved_in	GO:0007494	midgut development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0007371	ventral midline determination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0007228	positive regulation of hh target transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	C		Seeded From UniProt	complete
involved_in	GO:0003323	type B pancreatic cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0003140	determination of left/right asymmetry in lateral mesoderm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0001755	neural crest cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0001708	cell fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56726 ensembl:ENSMUSP00000001812	P		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	F		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000539 InterPro:IPR017981	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026544	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000539	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21931618^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097542	ciliary tip	Reactome:R-HSA-5610763	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	Reactome:R-HSA-5633040 Reactome:R-HSA-5632668	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-HSA-5632668 Reactome:R-HSA-5610763	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Marion, V et al. (2009) Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation. Proc. Natl. Acad. Sci. U.S.A. 106 1820-5 PubMed GONUTS page
↑ ^2.0 ^2.1 Huang, XH et al. (2011) miR-338-3p suppresses invasion of liver cancer cell by targeting smoothened. J. Pathol. 225 463-72 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^5.0 ^5.1 Xie, J et al. (1998) Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 391 90-2 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Karpen, HE et al. (2001) The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane. J. Biol. Chem. 276 19503-11 PubMed GONUTS page
↑ ^7.0 ^7.1 Carpenter, D et al. (1998) Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc. Natl. Acad. Sci. U.S.A. 95 13630-4 PubMed GONUTS page
↑ ^8.0 ^8.1 Jenkins, D et al. (2007) Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development. J. Anat. 211 620-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Roudaut, H et al. (2011) Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist. Mol. Pharmacol. 79 453-60 PubMed GONUTS page
↑ ^10.0 ^10.1 Rominger, CM et al. (2009) Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J. Pharmacol. Exp. Ther. 329 995-1005 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Bidet, M et al. (2011) The hedgehog receptor patched is involved in cholesterol transport. PLoS ONE 6 e23834 PubMed GONUTS page

[PMID:19190184-1] Marion, V et al. (2009) Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation. Proc. Natl. Acad. Sci. U.S.A. 106 1820-5 PubMed GONUTS page

[PMID:21671467-2] 2.0 ^2.1 Huang, XH et al. (2011) miR-338-3p suppresses invasion of liver cancer cell by targeting smoothened. J. Pathol. 225 463-72 PubMed GONUTS page

[PMID:23533145-3] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19056867-4] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:9422511-5] 5.0 ^5.1 Xie, J et al. (1998) Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 391 90-2 PubMed GONUTS page

[PMID:11278759-6] 6.0 ^6.1 ^6.2 Karpen, HE et al. (2001) The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane. J. Biol. Chem. 276 19503-11 PubMed GONUTS page

[PMID:9811851-7] 7.0 ^7.1 Carpenter, D et al. (1998) Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc. Natl. Acad. Sci. U.S.A. 95 13630-4 PubMed GONUTS page

[PMID:17850284-8] 8.0 ^8.1 Jenkins, D et al. (2007) Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development. J. Anat. 211 620-9 PubMed GONUTS page

[PMID:21177415-9] 9.0 ^9.1 Roudaut, H et al. (2011) Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist. Mol. Pharmacol. 79 453-60 PubMed GONUTS page

[PMID:19304771-10] 10.0 ^10.1 Rominger, CM et al. (2009) Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J. Pharmacol. Exp. Ther. 329 995-1005 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21931618-12] Bidet, M et al. (2011) The hedgehog receptor patched is involved in cholesterol transport. PLoS ONE 6 e23834 PubMed GONUTS page

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