HUMAN:SHC1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SHC1 (synonyms: SHC, SHCA)
Protein Name(s)	SHC-transforming protein 1 SHC-transforming protein 3 SHC-transforming protein A Src homology 2 domain-containing-transforming protein C1 SH2 domain protein C1
External Links
UniProt	P29353
EMBL	X68148 U73377 Y09847 AK292143 AK315842 AB451255 AB451379 AL451085 AL451085 AL451085 AL451085 AL451085 CH471121 CH471121 CH471121 CH471121 BC014158 BC033925
CCDS	CCDS1076.1 CCDS30881.1 CCDS44233.1 CCDS44234.1
PIR	S25776
RefSeq	NP_001123512.1 NP_001123513.1 NP_001189788.1 NP_003020.2 NP_892113.4
UniGene	Hs.433795
PDB	1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 1WCP 2L1C 4JMH 4XWX
PDBsum	1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 1WCP 2L1C 4JMH 4XWX
DisProt	DP00154
ProteinModelPortal	P29353
SMR	P29353
BioGrid	112361
DIP	DIP-699N
IntAct	P29353
MINT	MINT-123530
STRING	9606.ENSP00000401303
BindingDB	P29353
ChEMBL	CHEMBL5626
PhosphoSite	P29353
BioMuta	SHC1
DMDM	182676455
MaxQB	P29353
PaxDb	P29353
PRIDE	P29353
DNASU	6464
Ensembl	ENST00000368445 ENST00000368450 ENST00000368453 ENST00000448116
GeneID	6464
KEGG	hsa:6464
UCSC	uc001ffv.3 uc001ffw.3 uc001ffx.3
CTD	6464
GeneCards	GC01M154934
HGNC	HGNC:10840
HPA	CAB005374 CAB016305 HPA001844
MIM	600560
neXtProt	NX_P29353
PharmGKB	PA35746
eggNOG	NOG315087
GeneTree	ENSGT00390000018860
HOVERGEN	HBG050121
InParanoid	P29353
KO	K06279
OMA	FFPRMSN
OrthoDB	EOG7MD4QK
PhylomeDB	P29353
TreeFam	TF315807
Reactome	REACT_115852 REACT_115993 REACT_116005 REACT_118700 REACT_12033 REACT_12579 REACT_12621 REACT_147814 REACT_150139 REACT_15523 REACT_163701 REACT_163769 REACT_163834 REACT_1661 REACT_1695 REACT_18273 REACT_19290 REACT_23837 REACT_23891 REACT_267817 REACT_27283 REACT_355159 REACT_355194 REACT_355197 REACT_355225 REACT_508 REACT_661
SignaLink	P29353
ChiTaRS	SHC1
EvolutionaryTrace	P29353
GeneWiki	SHC1
GenomeRNAi	6464
NextBio	25115
PRO	PR:P29353
Proteomes	UP000005640
Bgee	P29353
ExpressionAtlas	P29353
Genevisible	P29353
GO	GO:0005829 GO:0010008 GO:0005759 GO:0005634 GO:0005886 GO:0070435 GO:0046875 GO:0005154 GO:0005158 GO:0005159 GO:0005168 GO:0005543 GO:0019901 GO:0004713 GO:0005068 GO:0031532 GO:0000187 GO:0007568 GO:0001525 GO:0007596 GO:0044267 GO:0030968 GO:0007173 GO:0038095 GO:0008543 GO:0007507 GO:0045087 GO:0008286 GO:0036498 GO:0050900 GO:0000165 GO:0031175 GO:0048011 GO:0031100 GO:0018108 GO:0030168 GO:0008284 GO:0045740 GO:0048661 GO:0045907 GO:0007265 GO:0007176 GO:0040008 GO:0051384 GO:0042542 GO:0001666 GO:0035094 GO:0009636 GO:0016337 GO:0016032
Gene3D	2.30.29.30 3.30.505.10
InterPro	IPR011993 IPR006019 IPR006020 IPR000980 IPR029586
PANTHER	PTHR10337:SF2
Pfam	PF00640 PF00017
PRINTS	PR00401 PR00629
SMART	SM00462 SM00252
SUPFAM	SSF55550
PROSITE	PS01179 PS50001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0007176	regulation of epidermal growth factor recep...		ECO:0000304			P		Source: ProtInc	Missing: reference
involved_in	GO:0071363	cellular response to growth factor stimulus	PMID:20010870^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:20624904^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:20624904^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20624904^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:20624904^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:20624904^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:20624904^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:20624904^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	PMID:20624904^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6GX35	F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	PMID:20624904^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O84462	F		Seeded From UniProt	complete
part_of	GO:0070435	Shc-EGFR complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5M824	C		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5M824	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5M824	P		Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5M824	F		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	PMID:12925710^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P54762	F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:14676841^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14676841^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005168	neurotrophin TRKA receptor binding	PMID:15488758^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04629	F		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	PMID:7541045^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	PMID:7537849^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:14676841^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:14676841^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2655364 MGI:MGI:98296 PANTHER:PTN000818658 RGD:620446	F		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000037430 RGD:620446	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98296 PANTHER:PTN000037430	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000818658 RGD:620446 UniProtKB:P29353	C		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98296 PANTHER:PTN000037430 RGD:620446 UniProtKB:P29353	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98083 ensembl:ENSMUSP00000091940	P		Seeded From UniProt	complete
enables	GO:0048408	epidermal growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98083 ensembl:ENSMUSP00000091940	F		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98083 ensembl:ENSMUSP00000091940	F		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98083 ensembl:ENSMUSP00000091940	P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98083 ensembl:ENSMUSP00000091940	P		Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98083 ensembl:ENSMUSP00000091940	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98083 ensembl:ENSMUSP00000091940	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98083 ensembl:ENSMUSP00000091940	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98083 ensembl:ENSMUSP00000091940	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98083 ensembl:ENSMUSP00000091940	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029586	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029586	P		Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029586	F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006019	P		Seeded From UniProt	complete
involved_in	GO:0090322	regulation of superoxide metabolic process	PMID:24177325^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS000059311D_9606	P	occurs_in:(CL:0010004)	Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:24177325^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS000059311D_9606	P	occurs_in:(CL:0010004)	Seeded From UniProt	complete
involved_in	GO:0071864	positive regulation of cell proliferation in bone marrow	PMID:24177325^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS000059311D_9606	P	results_in_division_of:(CL:0010004)	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:1623525^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007176	regulation of epidermal growth factor-activated receptor activity	PMID:1623525^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:1623525^[10] Reactome:R-HSA-177929	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	PMID:1623525^[10] PMID:14676841^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:14676841^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	Reactome:R-HSA-202733	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046579	positive regulation of Ras protein signal transduction	Reactome:R-HSA-9027284	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038128	ERBB2 signaling pathway	Reactome:R-HSA-1227986	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038110	interleukin-2-mediated signaling pathway	Reactome:R-HSA-9020558	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036498	IRE1-mediated unfolded protein response	Reactome:R-HSA-381070	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035723	interleukin-15-mediated signaling pathway	Reactome:R-HSA-8983432	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-512988 Reactome:R-HSA-451927	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	Reactome:R-HSA-74752	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	Reactome:R-HSA-422475	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	Reactome:R-HSA-167044	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5672965 Reactome:R-HSA-5654647 Reactome:R-HSA-5654646 Reactome:R-HSA-5654634 Reactome:R-HSA-5654600 Reactome:R-HSA-5654597 Reactome:R-HSA-5654582 Reactome:R-HSA-5654428 Reactome:R-HSA-5654426 Reactome:R-HSA-5654423 Reactome:R-HSA-5654407 Reactome:R-HSA-5654406 Reactome:R-HSA-5654402 Reactome:R-HSA-2404195 Reactome:R-HSA-2404193	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-913424 Reactome:R-HSA-913374 Reactome:R-HSA-912527 Reactome:R-HSA-9029150 Reactome:R-HSA-8983384 Reactome:R-HSA-8934465 Reactome:R-HSA-8934446 Reactome:R-HSA-8855508 Reactome:R-HSA-8854981 Reactome:R-HSA-8854905 Reactome:R-HSA-8854897 Reactome:R-HSA-8853793 Reactome:R-HSA-8853774 Reactome:R-HSA-8853737 Reactome:R-HSA-8853734 Reactome:R-HSA-8851900 Reactome:R-HSA-8851899 Reactome:R-HSA-8851890 Reactome:R-HSA-8851888 Reactome:R-HSA-879934 Reactome:R-HSA-879925 Reactome:R-HSA-74748 Reactome:R-HSA-74746 Reactome:R-HSA-74743 Reactome:R-HSA-74742 Reactome:R-HSA-74740 Reactome:R-HSA-5686074 Reactome:R-HSA-5686073 Reactome:R-HSA-5686072 Reactome:R-HSA-5685366 Reactome:R-HSA-5672965 Reactome:R-HSA-5654634 Reactome:R-HSA-5654625 Reactome:R-HSA-5654582 Reactome:R-HSA-5654573 Reactome:R-HSA-5654428 Reactome:R-HSA-5654425 Reactome:R-HSA-5654407 Reactome:R-HSA-5654404 Reactome:R-HSA-5637808 Reactome:R-HSA-5637798 Reactome:R-HSA-5637796 Reactome:R-HSA-5637766 Reactome:R-HSA-508247 Reactome:R-HSA-453111 Reactome:R-HSA-453104 Reactome:R-HSA-452100 Reactome:R-HSA-452091 Reactome:R-HSA-443910 Reactome:R-HSA-443905 Reactome:R-HSA-432096 Reactome:R-HSA-2730892 Reactome:R-HSA-2730889 Reactome:R-HSA-2730886 Reactome:R-HSA-2730870 Reactome:R-HSA-2730858 Reactome:R-HSA-2730856 Reactome:R-HSA-2730851 Reactome:R-HSA-2730847 Reactome:R-HSA-2730844 Reactome:R-HSA-2730842 Reactome:R-HSA-2730841 Reactome:R-HSA-2730840 Reactome:R-HSA-2730837 Reactome:R-HSA-2730833 Reactome:R-HSA-2424487 Reactome:R-HSA-2424486 Reactome:R-HSA-2424485 Reactome:R-HSA-2424484 Reactome:R-HSA-2424481 Reactome:R-HSA-2424477 Reactome:R-HSA-2424476 Reactome:R-HSA-2404193 Reactome:R-HSA-2396606 Reactome:R-HSA-2396599 Reactome:R-HSA-2396594 Reactome:R-HSA-2396561 Reactome:R-HSA-204861 Reactome:R-HSA-1791134 Reactome:R-HSA-177945 Reactome:R-HSA-177936 Reactome:R-HSA-177933 Reactome:R-HSA-177925 Reactome:R-HSA-1250383 Reactome:R-HSA-1250380 Reactome:R-HSA-1250357 Reactome:R-HSA-1250348 Reactome:R-HSA-1250195 Reactome:R-HSA-1225961 Reactome:R-HSA-1225957 Reactome:R-HSA-1225952 Reactome:R-HSA-1225947 Reactome:R-HSA-109822	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0341	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0170	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Heinrich, C et al. (2010) Copine-III interacts with ErbB2 and promotes tumor cell migration. Oncogene 29 1598-610 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Mehlitz, A et al. (2010) Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. J. Cell Biol. 190 143-57 PubMed GONUTS page
↑ Vindis, C et al. (2003) EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J. Cell Biol. 162 661-71 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Carloni, V et al. (2004) Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells. Oncogene 23 1566-74 PubMed GONUTS page
↑ Tacconelli, A et al. (2004) TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma. Cancer Cell 6 347-60 PubMed GONUTS page
↑ Craparo, A et al. (1995) Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J. Biol. Chem. 270 15639-43 PubMed GONUTS page
↑ Gustafson, TA et al. (1995) Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol. Cell. Biol. 15 2500-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Wang, JM et al. (2014) MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. Arterioscler. Thromb. Vasc. Biol. 34 99-109 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Pelicci, G et al. (1992) A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70 93-104 PubMed GONUTS page

[PMID:20010870-1] Heinrich, C et al. (2010) Copine-III interacts with ErbB2 and promotes tumor cell migration. Oncogene 29 1598-610 PubMed GONUTS page

[PMID:20624904-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Mehlitz, A et al. (2010) Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. J. Cell Biol. 190 143-57 PubMed GONUTS page

[PMID:12925710-3] Vindis, C et al. (2003) EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J. Cell Biol. 162 661-71 PubMed GONUTS page

[PMID:14676841-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Carloni, V et al. (2004) Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells. Oncogene 23 1566-74 PubMed GONUTS page

[PMID:15488758-5] Tacconelli, A et al. (2004) TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma. Cancer Cell 6 347-60 PubMed GONUTS page

[PMID:7541045-6] Craparo, A et al. (1995) Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J. Biol. Chem. 270 15639-43 PubMed GONUTS page

[PMID:7537849-7] Gustafson, TA et al. (1995) Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol. Cell. Biol. 15 2500-8 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24177325-9] 9.0 ^9.1 ^9.2 Wang, JM et al. (2014) MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. Arterioscler. Thromb. Vasc. Biol. 34 99-109 PubMed GONUTS page

[PMID:1623525-10] 10.0 ^10.1 ^10.2 ^10.3 Pelicci, G et al. (1992) A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70 93-104 PubMed GONUTS page

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