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HUMAN:SGOL1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SGOL1 (synonyms: SGO1)
Protein Name(s) Shugoshin-like 1

hSgo1 Serologically defined breast cancer antigen NY-BR-85

External Links
UniProt Q5FBB7
EMBL AB190994
AB193056
AB193057
AB193058
AB193059
AB193060
AB193061
AB193062
AB193063
AB193064
AB193065
AB193066
AB187577
AB187578
AB187579
AB187580
AB187581
AB187582
BC001339
BC017867
BC032696
AF308299
CCDS CCDS2635.1
CCDS33716.1
CCDS46771.1
CCDS46772.1
CCDS46773.1
CCDS46774.1
CCDS56243.1
RefSeq NP_001012409.1
NP_001012410.1
NP_001012411.1
NP_001012412.1
NP_001012413.1
NP_001186180.1
NP_001186181.1
NP_001186182.1
NP_001186183.1
NP_001186184.1
NP_001186185.1
NP_001186186.1
NP_612493.1
XP_006713049.1
XP_006713050.1
UniGene Hs.105153
PDB 3FGA
3Q6S
4A0I
PDBsum 3FGA
3Q6S
4A0I
ProteinModelPortal Q5FBB7
SMR Q5FBB7
BioGrid 127395
DIP DIP-36614N
IntAct Q5FBB7
MINT MINT-4989914
PhosphoSite Q5FBB7
DMDM 74741474
MaxQB Q5FBB7
PaxDb Q5FBB7
PRIDE Q5FBB7
Ensembl ENST00000263753
ENST00000306698
ENST00000412997
ENST00000417364
ENST00000419233
ENST00000421451
ENST00000425061
ENST00000437051
ENST00000442720
ENST00000443724
ENST00000452020
GeneID 151648
KEGG hsa:151648
UCSC uc003cbr.3
uc003cbs.3
uc003cbt.3
uc003cbx.3
uc003cby.3
uc010hfa.3
CTD 151648
GeneCards GC03M020179
HGNC HGNC:25088
HPA CAB011569
HPA035501
MIM 609168
neXtProt NX_Q5FBB7
PharmGKB PA134988556
eggNOG NOG47262
GeneTree ENSGT00390000014987
HOVERGEN HBG080777
InParanoid Q5FBB7
KO K11580
OMA CYYLTCQ
OrthoDB EOG7FXZZJ
PhylomeDB Q5FBB7
TreeFam TF334213
Reactome REACT_150425
REACT_150471
REACT_682
ChiTaRS SGOL1
EvolutionaryTrace Q5FBB7
GeneWiki SGOL1
GenomeRNAi 151648
NextBio 86755
PRO PR:Q5FBB7
Proteomes UP000005640
Bgee Q5FBB7
ExpressionAtlas Q5FBB7
Genevestigator Q5FBB7
GO GO:0005813
GO:0000775
GO:0000777
GO:0000779
GO:0000780
GO:0005737
GO:0005829
GO:0000776
GO:0030892
GO:0005634
GO:0000922
GO:0019900
GO:0008608
GO:0010457
GO:0007059
GO:0045132
GO:0000278
GO:0007067
InterPro IPR011515
IPR011516
Pfam PF07557
PF07558

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005813

centrosome

PMID:24157919[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

GO:0000775

chromosome, centromeric region

PMID:24055156[2]

ECO:0000314

C

Figure 1A

complete
CACAO 8642

involved_in

GO:0071962

mitotic sister chromatid cohesion, centromeric

PMID:24157919[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:24157919[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

PMID:24055156[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010457

centriole-centriole cohesion

PMID:18331714[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008608

attachment of spindle microtubules to kinetochore

PMID:17621308[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007059

chromosome segregation

PMID:16580887[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:18331714[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

PMID:18331714[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000779

condensed chromosome, centromeric region

PMID:19465021[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0000776

kinetochore

PMID:16582621[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:18331714[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0000776

kinetochore

PMID:17621308[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:17617734[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

PMID:16682347[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045132

meiotic chromosome segregation

PMID:18331714[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019900

kinase binding

PMID:18331714[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010457

centriole-centriole cohesion

PMID:18331714[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:18331714[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

PMID:18331714[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:18331714[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010457

centriole-centriole cohesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CXH7
ensembl:ENSMUSP00000024736

P

Seeded From UniProt

complete

part_of

GO:0000780

condensed nuclear chromosome, centromeric region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CXH7
ensembl:ENSMUSP00000024736

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CXH7
ensembl:ENSMUSP00000024736

C

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CXH7
ensembl:ENSMUSP00000024736

C

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011515
InterPro:IPR028321
InterPro:IPR038889

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011515

C

Seeded From UniProt

complete

involved_in

GO:0045132

meiotic chromosome segregation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011515

P

Seeded From UniProt

complete

involved_in

GO:0071962

mitotic sister chromatid cohesion, centromeric

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028321

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5666169
Reactome:R-HSA-5666160
Reactome:R-HSA-5666129
Reactome:R-HSA-375302
Reactome:R-HSA-2484822
Reactome:R-HSA-2468287
Reactome:R-HSA-2467811
Reactome:R-HSA-2467809
Reactome:R-HSA-1638821
Reactome:R-HSA-1638803
Reactome:R-HSA-141439
Reactome:R-HSA-141431
Reactome:R-HSA-141422
Reactome:R-HSA-141409

ECO:0000304

author statement supported by traceable reference used in manual assertion














C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

involved_in

GO:0007059

chromosome segregation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0159

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0137
UniProtKB-SubCell:SL-0047

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0995

C

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0448

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

part_of

GO:0000777

condensed chromosome kinetochore

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0149

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Porter, IM et al. (2013) Bod1 regulates protein phosphatase 2A at mitotic kinetochores. Nat Commun 4 2677 PubMed GONUTS page
  2. ↑ 2.0 2.1 Liu, H et al. (2013) Phospho-H2A and cohesin specify distinct tension-regulated Sgo1 pools at kinetochores and inner centromeres. Curr. Biol. 23 1927-33 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 Wang, X et al. (2008) sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. Dev. Cell 14 331-41 PubMed GONUTS page
  4. ↑ 4.0 4.1 Fu, G et al. (2007) Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis. Cell Res. 17 608-18 PubMed GONUTS page
  5. ↑ Tang, Z et al. (2006) PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev. Cell 10 575-85 PubMed GONUTS page
  6. ↑ Gambe, AE et al. (2009) A nucleolar protein RRS1 contributes to chromosome congression. FEBS Lett. 583 1951-6 PubMed GONUTS page
  7. ↑ Wang, X et al. (2006) Differential subcellular localizations of two human Sgo1 isoforms: implications in regulation of sister chromatid cohesion and microtubule dynamics. Cell Cycle 5 635-40 PubMed GONUTS page
  8. ↑ Pouwels, J et al. (2007) Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. Cell Cycle 6 1579-85 PubMed GONUTS page
  9. ↑ Watrin, E et al. (2006) Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Curr. Biol. 16 863-74 PubMed GONUTS page
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