HUMAN:SGMR1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SIGMAR1 (synonyms: OPRS1, SRBP)
Protein Name(s)	Sigma non-opioid intracellular receptor 1 Aging-associated gene 8 protein SR31747-binding protein SR-BP Sigma 1-type opioid receptor SIG-1R Sigma1-receptor Sigma1R hSigmaR1
External Links
UniProt	Q99720
EMBL	U75283 U79528 AF001977 AF001976 AF226604 AY633611 DQ644568 DQ647702 DQ656583 AK098451 CR457075 AK222899 AL450283 CH471071 CH471071 BC004899 BC007839
CCDS	CCDS6562.1 CCDS6563.1
PIR	JC5266
RefSeq	NP_001269134.1 NP_001269135.1 NP_001269136.1 NP_001269137.1 NP_001269138.1 NP_005857.1 NP_671513.1
UniGene	Hs.522087
ProteinModelPortal	Q99720
BioGrid	115569
IntAct	Q99720
BindingDB	Q99720
ChEMBL	CHEMBL287
DrugBank	DB00321 DB00514 DB00540 DB00652 DB00409
GuidetoPHARMACOLOGY	2552
PhosphoSite	Q99720
DMDM	74752153
MaxQB	Q99720
PaxDb	Q99720
PRIDE	Q99720
DNASU	10280
Ensembl	ENST00000277010 ENST00000353468 ENST00000477726
GeneID	10280
KEGG	hsa:10280
UCSC	uc003zuz.3 uc003zva.4
CTD	10280
GeneCards	GC09M034634
H-InvDB	HIX0008000 HIX0169361
HGNC	HGNC:8157
HPA	CAB013470 HPA018002 HPA024071
MIM	601978 614373
neXtProt	NX_Q99720
Orphanet	300605
PharmGKB	PA164725706
eggNOG	NOG296707
GeneTree	ENSGT00390000012082
HOVERGEN	HBG058220
InParanoid	Q99720
OMA	FYTLRAY
PhylomeDB	Q99720
TreeFam	TF300106
ChiTaRS	SIGMAR1
GeneWiki	Sigma-1_receptor
GenomeRNAi	10280
NextBio	38946
PRO	PR:Q99720
Proteomes	UP000005640
Bgee	Q99720
ExpressionAtlas	Q99720
Genevestigator	Q99720
GO	GO:0030054 GO:0005789 GO:0030426 GO:0016021 GO:0005887 GO:0005811 GO:0005635 GO:0005637 GO:0005640 GO:0008144 GO:0004985 GO:0006869 GO:0007399 GO:0043523
InterPro	IPR006716 IPR028545
PANTHER	PTHR10868
Pfam	PF04622

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0036474	cell death in response to hydrogen peroxide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55242	P	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:10406945^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:10406945^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0070207	protein homotrimerization	PMID:27042935^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99720	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:27042935^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:23314020^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043523	regulation of neuron apoptotic process	PMID:21842496^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:9341151^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001328958 UniProtKB:Q99720	C	Seeded From UniProt	complete
involved_in	GO:0038003	opioid receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004985	P	Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55242 ensembl:ENSMUSP00000056027	F	Seeded From UniProt	complete
involved_in	GO:0036474	cell death in response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55242 ensembl:ENSMUSP00000056027	P	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55242 ensembl:ENSMUSP00000056027	C	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C9 ensembl:ENSRNOP00000019795	P	Seeded From UniProt	complete
enables	GO:0004985	opioid receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C9 ensembl:ENSRNOP00000019795	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:27042935^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99720-1	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:9453537^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:8954936^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:8954936^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0445	P	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0551 UniProtKB-SubCell:SL-0154	C	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0179	C	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C	Seeded From UniProt	complete
part_of	GO:0005640	nuclear outer membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0183	C	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0178	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0288	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Dussossoy, D et al. (1999) Colocalization of sterol isomerase and sigma(1) receptor at endoplasmic reticulum and nuclear envelope level. Eur. J. Biochem. 263 377-86 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Schmidt, HR et al. (2016) Crystal structure of the human σ1 receptor. Nature 532 527-30 PubMed GONUTS page
↑ Prause, J et al. (2013) Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis. Hum. Mol. Genet. 22 1581-600 PubMed GONUTS page
↑ Al-Saif, A et al. (2011) A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis. Ann. Neurol. 70 913-9 PubMed GONUTS page
↑ Jbilo, O et al. (1997) Purification and characterization of the human SR 31747A-binding protein. A nuclear membrane protein related to yeast sterol isomerase. J. Biol. Chem. 272 27107-15 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Prasad, PD et al. (1998) Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene. J. Neurochem. 70 443-51 PubMed GONUTS page
↑ ^8.0 ^8.1 Kekuda, R et al. (1996) Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1). Biochem. Biophys. Res. Commun. 229 553-8 PubMed GONUTS page

[PMID:10406945-1] 1.0 ^1.1 Dussossoy, D et al. (1999) Colocalization of sterol isomerase and sigma(1) receptor at endoplasmic reticulum and nuclear envelope level. Eur. J. Biochem. 263 377-86 PubMed GONUTS page

[PMID:27042935-2] 2.0 ^2.1 ^2.2 Schmidt, HR et al. (2016) Crystal structure of the human σ1 receptor. Nature 532 527-30 PubMed GONUTS page

[PMID:23314020-3] Prause, J et al. (2013) Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis. Hum. Mol. Genet. 22 1581-600 PubMed GONUTS page

[PMID:21842496-4] Al-Saif, A et al. (2011) A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis. Ann. Neurol. 70 913-9 PubMed GONUTS page

[PMID:9341151-5] Jbilo, O et al. (1997) Purification and characterization of the human SR 31747A-binding protein. A nuclear membrane protein related to yeast sterol isomerase. J. Biol. Chem. 272 27107-15 PubMed GONUTS page

[PMID:21873635-6] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9453537-7] Prasad, PD et al. (1998) Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene. J. Neurochem. 70 443-51 PubMed GONUTS page

[PMID:8954936-8] 8.0 ^8.1 Kekuda, R et al. (1996) Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1). Biochem. Biophys. Res. Commun. 229 553-8 PubMed GONUTS page

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HUMAN:SGMR1

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