HUMAN:SETMR

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SETMAR (ECO:0000312 with HGNC:HGNC:10762)
Protein Name(s)	Histone-lysine N-methyltransferase SETMAR (ECO:0000305) SET domain and mariner transposase fusion protein (ECO:0000305) Metnase (ECO:0000303 with PMID:16332963^[1]) Histone-lysine N-methyltransferase (ECO:0000305) Transposon Hsmar1 transposase (ECO:0000303 with PMID:9461395^[2])
External Links
UniProt	Q53H47
EMBL	AK222734 AK302296 AC023483 AC034191 BC011635 AY952295 DQ341316 U52077
CCDS	CCDS2563.2 CCDS58814.1 CCDS63528.1
RefSeq	NP_001230652.1 NP_001263254.1 NP_006506.3
UniGene	Hs.475300
PDB	3BO5 3F2K 3K9J 3K9K
PDBsum	3BO5 3F2K 3K9J 3K9K
ProteinModelPortal	Q53H47
SMR	Q53H47
BioGrid	112317
IntAct	Q53H47
MINT	MINT-4826518
STRING	9606.ENSP00000373354
BindingDB	Q53H47
ChEMBL	CHEMBL2189111
PhosphoSite	Q53H47
DMDM	74740552
MaxQB	Q53H47
PaxDb	Q53H47
PRIDE	Q53H47
Ensembl	ENST00000358065 ENST00000425863 ENST00000430981
GeneID	6419
KEGG	hsa:6419
UCSC	uc010hbx.3
CTD	6419
GeneCards	GC03P004344
HGNC	HGNC:10762
MIM	609834
neXtProt	NX_Q53H47
PharmGKB	PA35680
eggNOG	COG2940
GeneTree	ENSGT00760000118855
HOGENOM	HOG000154295
HOVERGEN	HBG093941
InParanoid	Q53H47
KO	K11433
OMA	RRRSAQW
OrthoDB	EOG744T8D
PhylomeDB	Q53H47
TreeFam	TF352220
EvolutionaryTrace	Q53H47
GeneWiki	SETMAR
GenomeRNAi	6419
NextBio	24930
PRO	PR:Q53H47
Proteomes	UP000005640
Bgee	Q53H47
CleanEx	HS_SETMAR
ExpressionAtlas	Q53H47
Genevestigator	Q53H47
GO	GO:0005634 GO:0035861 GO:0044547 GO:0003690 GO:0004519 GO:0046975 GO:0042800 GO:0042803 GO:0003697 GO:0000014 GO:0043566 GO:0004803 GO:0008270 GO:0008283 GO:0000737 GO:0000729 GO:0015074 GO:0006303 GO:0010452 GO:0051568 GO:0044774 GO:0071157 GO:2001251 GO:0090305 GO:0018027 GO:2000373 GO:2001034 GO:0031297 GO:0006313
InterPro	IPR003616 IPR007728 IPR003606 IPR001214 IPR001888 IPR002492
Pfam	PF01498 PF05033 PF00856 PF01359
SMART	SM00508 SM00468 SM00317
PROSITE	PS50868 PS50867 PS50280

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	PMID:20457750^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0044547	DNA topoisomerase binding	PMID:20457750^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11388	F	Seeded From UniProt	complete
involved_in	GO:0031297	replication fork processing	PMID:20457750^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:20457750^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:21187428^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22231448^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	PMID:22231448^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	PMID:22231448^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0010452	histone H3-K36 methylation	PMID:22231448^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031297	replication fork processing	PMID:22231448^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:22231448^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051568	histone H3-K4 methylation	PMID:16332963^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042800	histone methyltransferase activity (H3-K4 specific)	PMID:16332963^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:16332963^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0015074	DNA integration	PMID:16332963^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044774	mitotic DNA integrity checkpoint	PMID:18790802^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0044547	DNA topoisomerase binding	PMID:18790802^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11388	F	Seeded From UniProt	complete
involved_in	GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	PMID:18790802^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	PMID:24573677^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0031297	replication fork processing	PMID:24573677^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:24573677^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0015074	DNA integration	PMID:24573677^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000737	DNA catabolic process, endonucleolytic	PMID:24573677^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	PMID:24573677^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:24573677^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:18263876^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:18263876^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
colocalizes_with	GO:0000793	condensed chromosome	PMID:18790802^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0010452	histone H3-K36 methylation	PMID:16332963^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046975	histone methyltransferase activity (H3-K36 specific)	PMID:16332963^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:21187428^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0097676	histone H3-K36 dimethylation	PMID:21187428^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2001251	negative regulation of chromosome organization	PMID:20620605^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	PMID:20620605^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	PMID:21491884^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071157	negative regulation of cell cycle arrest	PMID:19390626^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:20521842^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:20521842^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q53H47	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21491884^[10]	ECO:0000305	curator inference used in manual assertion	GO:0004519	C	Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	PMID:20620605^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	PMID:21491884^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000737	DNA catabolic process, endonucleolytic	PMID:20521842^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000737	DNA catabolic process, endonucleolytic	PMID:21491884^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000729	DNA double-strand break processing	PMID:21491884^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007728	C	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007728	F	Seeded From UniProt	complete
enables	GO:0018024	histone-lysine N-methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007728	F	Seeded From UniProt	complete
involved_in	GO:0034968	histone lysine methylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007728	P	Seeded From UniProt	complete
enables	GO:0018024	histone-lysine N-methyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.43	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21491884^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P	Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C	Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F	Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Lee, SH et al. (2005) The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair. Proc. Natl. Acad. Sci. U.S.A. 102 18075-80 PubMed GONUTS page
↑ Robertson, HM & Zumpano, KL (1997) Molecular evolution of an ancient mariner transposon, Hsmar1, in the human genome. Gene 205 203-17 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 De Haro, LP et al. (2010) Metnase promotes restart and repair of stalled and collapsed replication forks. Nucleic Acids Res. 38 5681-91 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Fnu, S et al. (2011) Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining. Proc. Natl. Acad. Sci. U.S.A. 108 540-5 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Hromas, R et al. (2012) Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart. Oncogene 31 4245-54 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Williamson, EA et al. (2008) The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation. Nucleic Acids Res. 36 5822-31 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Kim, HS et al. (2014) The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart. J. Biol. Chem. 289 10930-8 PubMed GONUTS page
↑ ^8.0 ^8.1 Beck, BD et al. (2008) Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair. J. Biol. Chem. 283 9023-30 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Wray, J et al. (2010) The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations. Cancer Genet. Cytogenet. 200 184-90 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Beck, BD et al. (2011) Biochemical characterization of metnase's endonuclease activity and its role in NHEJ repair. Biochemistry 50 4360-70 PubMed GONUTS page
↑ Wray, J et al. (2009) Metnase mediates resistance to topoisomerase II inhibitors in breast cancer cells. PLoS ONE 4 e5323 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Goodwin, KD et al. (2010) Crystal structure of the human Hsmar1-derived transposase domain in the DNA repair enzyme Metnase. Biochemistry 49 5705-13 PubMed GONUTS page

[PMID:16332963-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Lee, SH et al. (2005) The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair. Proc. Natl. Acad. Sci. U.S.A. 102 18075-80 PubMed GONUTS page

[PMID:9461395-2] Robertson, HM & Zumpano, KL (1997) Molecular evolution of an ancient mariner transposon, Hsmar1, in the human genome. Gene 205 203-17 PubMed GONUTS page

[PMID:20457750-3] 3.0 ^3.1 ^3.2 ^3.3 De Haro, LP et al. (2010) Metnase promotes restart and repair of stalled and collapsed replication forks. Nucleic Acids Res. 38 5681-91 PubMed GONUTS page

[PMID:21187428-4] 4.0 ^4.1 ^4.2 Fnu, S et al. (2011) Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining. Proc. Natl. Acad. Sci. U.S.A. 108 540-5 PubMed GONUTS page

[PMID:22231448-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Hromas, R et al. (2012) Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart. Oncogene 31 4245-54 PubMed GONUTS page

[PMID:18790802-6] 6.0 ^6.1 ^6.2 ^6.3 Williamson, EA et al. (2008) The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation. Nucleic Acids Res. 36 5822-31 PubMed GONUTS page

[PMID:24573677-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Kim, HS et al. (2014) The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart. J. Biol. Chem. 289 10930-8 PubMed GONUTS page

[PMID:18263876-8] 8.0 ^8.1 Beck, BD et al. (2008) Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair. J. Biol. Chem. 283 9023-30 PubMed GONUTS page

[PMID:20620605-9] 9.0 ^9.1 ^9.2 Wray, J et al. (2010) The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations. Cancer Genet. Cytogenet. 200 184-90 PubMed GONUTS page

[PMID:21491884-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Beck, BD et al. (2011) Biochemical characterization of metnase's endonuclease activity and its role in NHEJ repair. Biochemistry 50 4360-70 PubMed GONUTS page

[PMID:19390626-11] Wray, J et al. (2009) Metnase mediates resistance to topoisomerase II inhibitors in breast cancer cells. PLoS ONE 4 e5323 PubMed GONUTS page

[PMID:20521842-12] 12.0 ^12.1 ^12.2 Goodwin, KD et al. (2010) Crystal structure of the human Hsmar1-derived transposase domain in the DNA repair enzyme Metnase. Biochemistry 49 5705-13 PubMed GONUTS page

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HUMAN:SETMR

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References

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