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HUMAN:SETB1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SETDB1 (synonyms: KIAA0067, KMT1E) | |
| Protein Name(s) | Histone-lysine N-methyltransferase SETDB1
ERG-associated protein with SET domain ESET Histone H3-K9 methyltransferase 4 H3-K9-HMTase 4 Lysine N-methyltransferase 1E SET domain bifurcated 1 | |
| External Links | ||
| UniProt | Q15047 | |
| EMBL | D31891 AL590133 AL590133 AL590133 AL590133 CH471121 BC009362 BC028671 | |
| CCDS | CCDS44217.1 CCDS58026.1 CCDS972.1 | |
| RefSeq | NP_001138887.1 NP_001230420.1 NP_036564.3 | |
| UniGene | Hs.643565 | |
| PDB | 3DLM | |
| PDBsum | 3DLM | |
| ProteinModelPortal | Q15047 | |
| SMR | Q15047 | |
| BioGrid | 115202 | |
| DIP | DIP-31029N | |
| IntAct | Q15047 | |
| MINT | MINT-1184137 | |
| STRING | 9606.ENSP00000357965 | |
| ChEMBL | CHEMBL2321646 | |
| PhosphoSite | Q15047 | |
| DMDM | 25091210 | |
| MaxQB | Q15047 | |
| PaxDb | Q15047 | |
| PRIDE | Q15047 | |
| Ensembl | ENST00000271640 ENST00000368962 ENST00000368969 | |
| GeneID | 9869 | |
| KEGG | hsa:9869 | |
| UCSC | uc001evu.2 uc001evv.2 uc001evw.4 | |
| CTD | 9869 | |
| GeneCards | GC01P150898 | |
| HGNC | HGNC:10761 | |
| HPA | HPA018142 | |
| MIM | 604396 | |
| neXtProt | NX_Q15047 | |
| PharmGKB | PA35679 | |
| eggNOG | COG2940 | |
| GeneTree | ENSGT00760000119330 | |
| HOVERGEN | HBG061013 | |
| InParanoid | Q15047 | |
| KO | K11421 | |
| OMA | SKTSMHQ | |
| OrthoDB | EOG7ZD1TG | |
| PhylomeDB | Q15047 | |
| TreeFam | TF106411 | |
| ChiTaRS | SETDB1 | |
| EvolutionaryTrace | Q15047 | |
| GeneWiki | SETDB1 | |
| GenomeRNAi | 9869 | |
| NextBio | 37203 | |
| PRO | PR:Q15047 | |
| Proteomes | UP000005640 | |
| Bgee | Q15047 | |
| CleanEx | HS_SETDB1 | |
| ExpressionAtlas | Q15047 | |
| Genevestigator | Q15047 | |
| GO | GO:0005737 GO:0005794 GO:0000790 GO:0005634 GO:0005886 GO:0003677 GO:0018024 GO:0008270 GO:0060348 GO:0036124 GO:0001833 GO:0000122 GO:0006351 | |
| InterPro | IPR016177 IPR025796 IPR001739 IPR003616 IPR007728 IPR003606 IPR001214 IPR002999 | |
| Pfam | PF01429 PF05033 PF00856 | |
| SMART | SM00391 SM00508 SM00468 SM00317 SM00333 | |
| SUPFAM | SSF54171 | |
| PROSITE | PS50982 PS50868 PS50867 PS51573 PS50280 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090309 |
positive regulation of methylation-dependent chromatin silencing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090309 |
positive regulation of methylation-dependent chromatin silencing |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045869 |
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046974 |
histone methyltransferase activity (H3-K9 specific) |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0018024 |
histone-lysine N-methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007265 |
Ras protein signal transduction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090309 |
positive regulation of methylation-dependent chromatin silencing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:1990841 |
promoter-specific chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051567 |
histone H3-K9 methylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046974 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045471 |
response to ethanol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K5A7 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033273 |
response to vitamin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K5A7 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0018024 |
histone-lysine N-methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034968 |
histone lysine methylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0018024 |
histone-lysine N-methyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-5159250 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Timms, RT et al. (2016) ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex. Cell Rep 17 653-659 PubMed GONUTS page
- ↑ 2.0 2.1 Wang, H et al. (2003) mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol. Cell 12 475-87 PubMed GONUTS page
- ↑ Valle-García, D et al. (2016) ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment. Epigenetics 11 398-414 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Serra, RW et al. (2014) A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife 3 e02313 PubMed GONUTS page
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