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HUMAN:SEPT7

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SEPT7 (synonyms: CDC10)
Protein Name(s) Septin-7

CDC10 protein homolog

External Links
UniProt Q16181
EMBL S72008
BC067264
BC093640
BC093642
PIR JC2352
RefSeq NP_001779.3
UniGene Hs.191346
PDB 2QAG
3T5D
3TW4
PDBsum 2QAG
3T5D
3TW4
ProteinModelPortal Q16181
SMR Q16181
BioGrid 107425
DIP DIP-47093N
IntAct Q16181
MINT MINT-5006116
STRING 9606.ENSP00000381992
iPTMnet Q16181
PhosphoSitePlus Q16181
SwissPalm Q16181
BioMuta SEPT7
DMDM 67472677
OGP Q16181
UCD-2DPAGE Q16181
EPD Q16181
MaxQB Q16181
PaxDb Q16181
PeptideAtlas Q16181
PRIDE Q16181
DNASU 989
Ensembl ENST00000399034
GeneID 989
KEGG hsa:989
UCSC uc011kau.2
CTD 989
DisGeNET 989
GeneCards SEPT7
H-InvDB HIX0006599
HIX0032379
HGNC HGNC:1717
HPA HPA023309
HPA029524
MIM 603151
neXtProt NX_Q16181
PharmGKB PA26253
eggNOG KOG2655
COG5019
HOGENOM HOG000233586
HOVERGEN HBG065093
InParanoid Q16181
KO K16944
PhylomeDB Q16181
TreeFam TF101079
Reactome [www.reactome.org/content/detail/R-HSA-5687128 R-HSA-5687128]
SIGNOR Q16181
ChiTaRS SEPT7
EvolutionaryTrace Q16181
GeneWiki SEPT7
GenomeRNAi 989
PRO PR:Q16181
Proteomes UP000005640
Bgee ENSG00000122545
CleanEx HS_SEPT7
ExpressionAtlas Q16181
Genevisible Q16181
GO GO:0005930
GO:0032154
GO:0000777
GO:0005829
GO:0070062
GO:0030496
GO:0097730
GO:0005634
GO:0031105
GO:0097227
GO:0005819
GO:0001725
GO:0045296
GO:0005525
GO:0042802
GO:0005198
GO:0030154
GO:0060271
GO:0000910
GO:0007067
GO:1902857
GO:0051291
GO:0016476
GO:0007283
CDD cd01850
Gene3D 3.40.50.300
InterPro IPR030379
IPR027417
IPR016491
IPR008115
PANTHER PTHR18884
Pfam PF00735
PIRSF PIRSF006698
PRINTS PR01742
SUPFAM SSF52540
PROSITE PS51719

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:23383034[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

PMID:23383034[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030336

negative regulation of cell migration

PMID:23383034[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0045296

cadherin binding

PMID:25468996[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031105

septin complex

PMID:25588830[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0097227

sperm annulus

PMID:25588830[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031105

septin complex

PMID:23572511[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002586)

Seeded From UniProt

complete

involved_in

GO:1902857

positive regulation of non-motile cilium assembly

PMID:23572511[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002586)

Seeded From UniProt

complete

part_of

GO:0005930

axoneme

PMID:23572511[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002586)

Seeded From UniProt

complete

part_of

GO:0097730

non-motile cilium

PMID:23572511[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002586)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6GLZ5

P

Seeded From UniProt

complete

involved_in

GO:0051291

protein heterooligomerization

PMID:15485874[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016476

regulation of embryonic cell shape

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6GLZ5

P

Seeded From UniProt

complete

colocalizes_with

GO:0016324

apical plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6GLZ5

C

Seeded From UniProt

complete

part_of

GO:0005930

axoneme

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6GLZ5

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15485874[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0001725

stress fiber

PMID:15485874[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0061640

cytoskeleton-dependent cytokinesis

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0013726
FB:FBgn0014029
MGI:MGI:1335094
PANTHER:PTN000430171
PomBase:SPAC4F10.11
PomBase:SPAC821.06
PomBase:SPAC9G1.11c
PomBase:SPBC16A3.01
SGD:S000000595
SGD:S000001149
SGD:S000002384
SGD:S000003837
SGD:S000004306

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001051477
ZFIN:ZDB-GENE-061103-265

P

Seeded From UniProt

complete

enables

GO:0060090

molecular adaptor activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97298
PANTHER:PTN000430171
SGD:S000000595
SGD:S000001149

F

Seeded From UniProt

complete

part_of

GO:0031105

septin complex

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011710
FB:FBgn0013726
FB:FBgn0014029
MGI:MGI:1335094
PANTHER:PTN000430171
PomBase:SPAC4F10.11
PomBase:SPAC821.06
PomBase:SPAC9G1.11c
PomBase:SPBC16A3.01
RGD:621763
SGD:S000000595
SGD:S000001149
SGD:S000002626
SGD:S000003291
SGD:S000003837
SGD:S000004306
UniProtKB:O43236
UniProtKB:Q14141
UniProtKB:Q15019
UniProtKB:Q16181
UniProtKB:Q8IYM1
UniProtKB:Q9UHD8

C

Seeded From UniProt

complete

part_of

GO:0015630

microtubule cytoskeleton

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000430171
UniProtKB:Q8IYM1

C

Seeded From UniProt

complete

part_of

GO:0005940

septin ring

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000177264
CGD:CAL0000186883
CGD:CAL0000188354
MGI:MGI:1335094
MGI:MGI:1888939
PANTHER:PTN000430171
PomBase:SPAC9G1.11c
UniProtKB:A0A1D8PCY5
UniProtKB:A0A1D8PD83

C

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011710
FB:FBgn0013726
PANTHER:PTN000430171
SGD:S000000595
SGD:S000001149
UniProtKB:O43236

F

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011710
FB:FBgn0013726
FB:FBgn0014029
PANTHER:PTN000430171
SGD:S000000595
SGD:S000001149
UniProtKB:O43236

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:22064074[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q16181

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008115
InterPro:IPR016491
InterPro:IPR030379

F

Seeded From UniProt

complete

part_of

GO:0031105

septin complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008115

C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

PMID:8037772[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

PMID:8037772[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5692775
Reactome:R-HSA-5692770

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0137

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

part_of

GO:0031514

motile cilium

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0282
UniProtKB-SubCell:SL-0117

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0995

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0744

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0969

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

part_of

GO:0005819

spindle

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0251

C

Seeded From UniProt

complete

part_of

GO:0030496

midbody

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0469

C

Seeded From UniProt

complete

part_of

GO:0000777

condensed chromosome kinetochore

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0149

C

Seeded From UniProt

complete

part_of

GO:0032154

cleavage furrow

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0467

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Jia, Z et al. (2013) MiR-30a-5p antisense oligonucleotide suppresses glioma cell growth by targeting SEPT7. PLoS ONE 8 e55008 PubMed GONUTS page
  2. ↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
  3. ↑ 3.0 3.1 Kuo, YC et al. (2015) SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins. J. Cell. Sci. 128 923-34 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Ghossoub, R et al. (2013) Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length. J. Cell. Sci. 126 2583-94 PubMed GONUTS page
  5. ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Nagata, K et al. (2004) Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11. J. Biol. Chem. 279 55895-904 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. ↑ Serrão, VH et al. (2011) Promiscuous interactions of human septins: the GTP binding domain of SEPT7 forms filaments within the crystal. FEBS Lett. 585 3868-73 PubMed GONUTS page
  9. ↑ 9.0 9.1 Nakatsuru, S et al. (1994) Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 202 82-7 PubMed GONUTS page
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