HUMAN:SENP2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SENP2 (synonyms: KIAA1331)
Protein Name(s)	Sentrin-specific protease 2 Axam2 SMT3-specific isopeptidase 2 Smt3ip2 Sentrin/SUMO-specific protease SENP2
External Links
UniProt	Q9HC62
EMBL	AF151697 AB037752 AK027599 AK298628 AC016961 AC133473 BC040609 AL834380
CCDS	CCDS33902.1
RefSeq	NP_067640.2
UniGene	Hs.401388
PDB	1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3 3ZO5
PDBsum	1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3 3ZO5
ProteinModelPortal	Q9HC62
SMR	Q9HC62
BioGrid	121885
DIP	DIP-29254N
IntAct	Q9HC62
MINT	MINT-1389034
STRING	9606.ENSP00000296257
BindingDB	Q9HC62
ChEMBL	CHEMBL2176776
MEROPS	C48.007
PhosphoSite	Q9HC62
DMDM	143811458
MaxQB	Q9HC62
PaxDb	Q9HC62
PRIDE	Q9HC62
Ensembl	ENST00000296257
GeneID	59343
KEGG	hsa:59343
UCSC	uc003fpn.3
CTD	59343
GeneCards	GC03P185301
HGNC	HGNC:23116
HPA	HPA029247 HPA029248
MIM	608261
neXtProt	NX_Q9HC62
PharmGKB	PA134955185
eggNOG	COG5160
GeneTree	ENSGT00530000062941
HOGENOM	HOG000070234
HOVERGEN	HBG054228
InParanoid	Q9HC62
KO	K03345
OMA	RRGYQLE
OrthoDB	EOG7D59MP
PhylomeDB	Q9HC62
TreeFam	TF316289
BRENDA	3.4.22.68
Reactome	REACT_163725
ChiTaRS	SENP2
EvolutionaryTrace	Q9HC62
GeneWiki	SENP2
GenomeRNAi	59343
NextBio	35474035
PRO	PR:Q9HC62
Proteomes	UP000005640
Bgee	Q9HC62
CleanEx	HS_SENP2
ExpressionAtlas	Q9HC62
Genevestigator	Q9HC62
GO	GO:0031410 GO:0031965 GO:0005643 GO:0005654 GO:0016605 GO:0016929 GO:0044267 GO:0009950 GO:0007507 GO:0060711 GO:0051028 GO:0035562 GO:0043518 GO:0032091 GO:0001934 GO:0045944 GO:0043687 GO:0016926 GO:0016925 GO:0015031 GO:0032875 GO:2000045 GO:0030111 GO:0060712 GO:0060707 GO:0016055
InterPro	IPR003653
Pfam	PF02902
PROSITE	PS50600

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0031397	negative regulation of protein ubiquitination	PMID:22028379^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
	GO:0016926	protein desumoylation	PMID:22028379^[1]	ECO:0000315			P	Fig. 5A-C	complete CACAO 2615
involved_in	GO:0016926	protein desumoylation	PMID:20194620^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
	GO:0031648	protein destabilization	PMID:22028379^[1]	ECO:0000315			P	Fig. 6B	complete CACAO 2616
involved_in	GO:0045444	fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91ZX6	P	Seeded From UniProt	complete
	GO:0031398	positive regulation of protein ubiquitination	PMID:22028379^[1]	ECO:0000315			P	Fig. 7(A-F) K48-Linked Ubiquitination	complete CACAO 2617
involved_in	GO:0031398	positive regulation of protein ubiquitination	PMID:22028379^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
	GO:0031397	negative regulation of protein ubiquitination	PMID:22028379^[1]	ECO:0000314			P	Supplementary Fig. S2A K63-Linked Ubiquitination	complete CACAO 2618
involved_in	GO:0031648	protein destabilization	PMID:22028379^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
	GO:0050687	negative regulation of defense response to virus	PMID:22028379^[1]	ECO:0000315			P	Fig. 1, Fig. 2, and Fig. 3	complete CACAO 2619
involved_in	GO:0016926	protein desumoylation	PMID:22028379^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016926	protein desumoylation	PMID:21965678^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030111	regulation of Wnt signaling pathway	PMID:11896061^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0070139	SUMO-specific endopeptidase activity	PMID:11896061^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
colocalizes_with	GO:0016605	PML body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91ZX6	C	Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	PMID:12192048^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016926	protein desumoylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0027603 MGI:MGI:1923076 MGI:MGI:2445054 PANTHER:PTN000288424 PomBase:SPBC19G7.09 SGD:S000001293 SGD:S000005941 TAIR:locus:2077632 TAIR:locus:2130864 UniProtKB:A0A1D8PIW0 UniProtKB:A0A1D8PSK4 UniProtKB:Q5B9U1 UniProtKB:Q9HC62 UniProtKB:Q9P0U3 WB:WBGene00006736 WB:WBGene00006737	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0027603 MGI:MGI:1923076 PANTHER:PTN000288424 PomBase:SPBC19G7.09 SGD:S000001293 TAIR:locus:2130864 UniProtKB:Q9H4L4 UniProtKB:Q9P0U3 WB:WBGene00006737	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2000045	regulation of G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZX6 ensembl:ENSMUSP00000023561	P	Seeded From UniProt	complete
enables	GO:0070140	SUMO-specific isopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZX6 ensembl:ENSMUSP00000023561	F	Seeded From UniProt	complete
involved_in	GO:0060712	spongiotrophoblast layer development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZX6 ensembl:ENSMUSP00000023561	P	Seeded From UniProt	complete
involved_in	GO:0060711	labyrinthine layer development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZX6 ensembl:ENSMUSP00000023561	P	Seeded From UniProt	complete
involved_in	GO:0060707	trophoblast giant cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZX6 ensembl:ENSMUSP00000023561	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZX6 ensembl:ENSMUSP00000023561	P	Seeded From UniProt	complete
involved_in	GO:0045444	fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZX6 ensembl:ENSMUSP00000023561	P	Seeded From UniProt	complete
involved_in	GO:0035562	negative regulation of chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZX6 ensembl:ENSMUSP00000023561	P	Seeded From UniProt	complete
involved_in	GO:0032875	regulation of DNA endoreduplication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZX6 ensembl:ENSMUSP00000023561	P	Seeded From UniProt	complete
involved_in	GO:0016926	protein desumoylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZX6 ensembl:ENSMUSP00000023561	P	Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZX6 ensembl:ENSMUSP00000023561	C	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZX6 ensembl:ENSMUSP00000023561	C	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91ZX6 ensembl:ENSMUSP00000023561	P	Seeded From UniProt	complete
involved_in	GO:0051246	regulation of protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQE1 ensembl:ENSRNOP00000002425	P	Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQE1 ensembl:ENSRNOP00000002425	P	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQE1 ensembl:ENSRNOP00000002425	F	Seeded From UniProt	complete
involved_in	GO:0009950	dorsal/ventral axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQE1 ensembl:ENSRNOP00000002425	P	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQE1 ensembl:ENSRNOP00000002425	P	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003653	P	Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003653	F	Seeded From UniProt	complete
involved_in	GO:0016925	protein sumoylation	Reactome:R-HSA-3065679	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-2993763 Reactome:R-HSA-2990842 Reactome:R-HSA-2990840	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0811 UniProtKB-KW:KW-0653	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F	Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0906 UniProtKB-SubCell:SL-0185	C	Seeded From UniProt	complete
involved_in	GO:0051028	mRNA transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0509	P	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0182	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Ran, Y et al. (2011) SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation. J Mol Cell Biol 3 283-92 PubMed GONUTS page
↑ Chung, SS et al. (2010) Control of adipogenesis by the SUMO-specific protease SENP2. Mol. Cell. Biol. 30 2135-46 PubMed GONUTS page
↑ Cong, L et al. (2011) SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. J. Biol. Chem. 286 43793-808 PubMed GONUTS page
↑ ^4.0 ^4.1 Hang, J & Dasso, M (2002) Association of the human SUMO-1 protease SENP2 with the nuclear pore. J. Biol. Chem. 277 19961-6 PubMed GONUTS page
↑ Zhang, H et al. (2002) Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. Mol. Cell. Biol. 22 6498-508 PubMed GONUTS page
↑ ^6.0 ^6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22028379-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Ran, Y et al. (2011) SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation. J Mol Cell Biol 3 283-92 PubMed GONUTS page

[PMID:20194620-2] Chung, SS et al. (2010) Control of adipogenesis by the SUMO-specific protease SENP2. Mol. Cell. Biol. 30 2135-46 PubMed GONUTS page

[PMID:21965678-3] Cong, L et al. (2011) SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. J. Biol. Chem. 286 43793-808 PubMed GONUTS page

[PMID:11896061-4] 4.0 ^4.1 Hang, J & Dasso, M (2002) Association of the human SUMO-1 protease SENP2 with the nuclear pore. J. Biol. Chem. 277 19961-6 PubMed GONUTS page

[PMID:12192048-5] Zhang, H et al. (2002) Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. Mol. Cell. Biol. 22 6498-508 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:SENP2

Contents

Annotations

Notes

References

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