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HUMAN:SDHF2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SDHAF2 (ECO:0000255 with HAMAP-Rule:MF_03057)
Protein Name(s) Succinate dehydrogenase assembly factor 2, mitochondrial (ECO:0000255 with HAMAP-Rule:MF_03057)

SDH assembly factor 2 (ECO:0000255 with HAMAP-Rule:MF_03057) SDHAF2 (ECO:0000255 with HAMAP-Rule:MF_03057)

External Links
UniProt Q9NX18
EMBL AK000494
BC002331
CCDS CCDS8007.1
RefSeq NP_060311.1
UniGene Hs.313247
ProteinModelPortal Q9NX18
SMR Q9NX18
BioGrid 120288
IntAct Q9NX18
MINT MINT-1381599
STRING 9606.ENSP00000301761
PhosphoSite Q9NX18
DMDM 74734683
MaxQB Q9NX18
PaxDb Q9NX18
PRIDE Q9NX18
DNASU 54949
Ensembl ENST00000301761
GeneID 54949
KEGG hsa:54949
UCSC uc001nrt.3
CTD 54949
GeneCards GC11P061198
GeneReviews SDHAF2
HGNC HGNC:26034
HPA HPA039464
HPA039732
MIM 601650
613019
neXtProt NX_Q9NX18
Orphanet 29072
PharmGKB PA165543618
eggNOG COG2938
GeneTree ENSGT00390000001149
HOGENOM HOG000230636
InParanoid Q9NX18
KO K18168
OMA YLFEKPH
PhylomeDB Q9NX18
TreeFam TF300175
ChiTaRS SDHAF2
GenomeRNAi 54949
NextBio 58119
PRO PR:Q9NX18
Proteomes UP000005640
Bgee Q9NX18
CleanEx HS_C11orf79
ExpressionAtlas Q9NX18
Genevestigator Q9NX18
GO GO:0005739
GO:0006121
GO:0090090
GO:0010719
GO:0006470
GO:0018293
Gene3D 1.10.150.250
HAMAP MF_03057
InterPro IPR005631
IPR028882
Pfam PF03937
SUPFAM SSF109910

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0018293

protein-FAD linkage

PMID:19628817[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006121

mitochondrial electron transport, succinate to ubiquinone

PMID:19628817[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:19628817[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0034553

mitochondrial respiratory chain complex II assembly

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000279729
SGD:S000005432

P

Seeded From UniProt

complete

involved_in

GO:0018293

protein-FAD linkage

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000279729
SGD:S000005432
UniProtKB:Q9NX18

P

Seeded From UniProt

complete

involved_in

GO:0006121

mitochondrial electron transport, succinate to ubiquinone

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000279729
UniProtKB:Q9NX18

P

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000279729
SGD:S000005432

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000279729
UniProtKB:Q9FI44
UniProtKB:Q9NX18

C

Seeded From UniProt

complete

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

PMID:23983127[3]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P35222

P

Seeded From UniProt

complete

involved_in

GO:0010719

negative regulation of epithelial to mesenchymal transition

PMID:23983127[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

PMID:23983127[3]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P67775

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8C6I2
ensembl:ENSMUSP00000025570

P

Seeded From UniProt

complete

involved_in

GO:0010719

negative regulation of epithelial to mesenchymal transition

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8C6I2
ensembl:ENSMUSP00000025570

P

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8C6I2
ensembl:ENSMUSP00000025570

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028882

C

Seeded From UniProt

complete

involved_in

GO:0018293

protein-FAD linkage

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028882

P

Seeded From UniProt

complete

involved_in

GO:0006121

mitochondrial electron transport, succinate to ubiquinone

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000369524

P

Seeded From UniProt

complete

involved_in

GO:0018293

protein-FAD linkage

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000369524

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000369524

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Hao, HX et al. (2009) SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science 325 1139-42 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Liu, J et al. (2013) Succinate dehydrogenase 5 (SDH5) regulates glycogen synthase kinase 3β-β-catenin-mediated lung cancer metastasis. J. Biol. Chem. 288 29965-73 PubMed GONUTS page
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