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HUMAN:SDC4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SDC4
Protein Name(s) Syndecan-4

SYND4 Amphiglycan Ryudocan core protein

External Links
UniProt P31431
EMBL X67016
D13292
D79206
AK312507
CR542045
CR542074
AK222695
AK223243
AL021578
CH471077
CH471077
BC030805
AA151028
AA258502
CCDS CCDS13350.1
PIR JC1457
RefSeq NP_002990.2
UniGene Hs.632267
PDB 1EJP
1EJQ
1OBY
1YBO
PDBsum 1EJP
1EJQ
1OBY
1YBO
ProteinModelPortal P31431
SMR P31431
BioGrid 112286
DIP DIP-29945N
IntAct P31431
MINT MINT-140673
STRING 9606.ENSP00000361818
TCDB 9.A.35.1.1
PhosphoSite P31431
DMDM 2851418
MaxQB P31431
PaxDb P31431
PRIDE P31431
DNASU 6385
Ensembl ENST00000372733
GeneID 6385
KEGG hsa:6385
UCSC uc002xnu.3
CTD 6385
GeneCards GC20M043953
HGNC HGNC:10661
HPA CAB013240
HPA005716
MIM 600017
neXtProt NX_P31431
PharmGKB PA35591
eggNOG NOG83582
GeneTree ENSGT00530000063116
HOGENOM HOG000263414
HOVERGEN HBG004501
InParanoid P31431
KO K16338
OMA NHIPERA
OrthoDB EOG7RV9HS
PhylomeDB P31431
TreeFam TF320463
Reactome REACT_120752
REACT_121248
REACT_121408
REACT_163942
REACT_24968
REACT_267654
REACT_267659
REACT_267674
REACT_267711
ChiTaRS SDC4
EvolutionaryTrace P31431
GeneWiki SDC4
GenomeRNAi 6385
NextBio 24792
PMAP-CutDB P31431
PRO PR:P31431
Proteomes UP000005640
Bgee P31431
CleanEx HS_SDC4
ExpressionAtlas P31431
Genevestigator P31431
GO GO:0009986
GO:0043034
GO:0070062
GO:0005925
GO:0005796
GO:0005887
GO:0043202
GO:0045121
GO:0005886
GO:0070053
GO:0005975
GO:0030204
GO:0030198
GO:0006024
GO:0006027
GO:0030203
GO:0007603
GO:1903543
GO:1903553
GO:0051894
GO:0045860
GO:0051496
GO:0001523
GO:0044281
GO:0001657
InterPro IPR003585
IPR001050
IPR027789
PANTHER PTHR10915
Pfam PF01034
SMART SM00294
PROSITE PS00964

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0042130

negative regulation of T cell proliferation

PMID:19350579[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903553

positive regulation of extracellular exosome assembly

PMID:22660413[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903543

positive regulation of exosomal secretion

PMID:22660413[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19199708[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

enables

GO:0070053

thrombospondin receptor activity

PMID:17879962[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:1500433[5]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000099415
ZFIN:ZDB-GENE-061111-1

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1349162
MGI:MGI:1349164
PANTHER:PTN000099415
RGD:3650
UniProtKB:P18827
WB:WBGene00004749

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:18093920[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P31431

F

Seeded From UniProt

complete

involved_in

GO:0060122

inner ear receptor cell stereocilium organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35988
ensembl:ENSMUSP00000017153

P

Seeded From UniProt

complete

involved_in

GO:0042060

wound healing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35988
ensembl:ENSMUSP00000017153

P

Seeded From UniProt

complete

involved_in

GO:0010762

regulation of fibroblast migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35988
ensembl:ENSMUSP00000017153

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35988
ensembl:ENSMUSP00000017153

C

Seeded From UniProt

complete

involved_in

GO:0001843

neural tube closure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35988
ensembl:ENSMUSP00000017153

P

Seeded From UniProt

complete

involved_in

GO:0051894

positive regulation of focal adhesion assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34901
ensembl:ENSRNOP00000019386

P

Seeded From UniProt

complete

involved_in

GO:0051496

positive regulation of stress fiber assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34901
ensembl:ENSRNOP00000019386

P

Seeded From UniProt

complete

involved_in

GO:0045860

positive regulation of protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34901
ensembl:ENSRNOP00000019386

P

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34901
ensembl:ENSRNOP00000019386

C

Seeded From UniProt

complete

part_of

GO:0043034

costamere

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34901
ensembl:ENSRNOP00000019386

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34901
ensembl:ENSRNOP00000019386

F

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34901
ensembl:ENSRNOP00000019386

C

Seeded From UniProt

complete

part_of

GO:0005925

focal adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34901
ensembl:ENSRNOP00000019386

C

Seeded From UniProt

complete

enables

GO:0005080

protein kinase C binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34901
ensembl:ENSRNOP00000019386

F

Seeded From UniProt

complete

enables

GO:0001968

fibronectin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34901
ensembl:ENSRNOP00000019386

F

Seeded From UniProt

complete

involved_in

GO:0001657

ureteric bud development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34901
ensembl:ENSRNOP00000019386

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001050

C

Seeded From UniProt

complete

involved_in

GO:0050900

leukocyte migration

Reactome:R-HSA-202733

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043202

lysosomal lumen

Reactome:R-HSA-2024084
Reactome:R-HSA-1667005

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0006027

glycosaminoglycan catabolic process

Reactome:R-HSA-2024096

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006024

glycosaminoglycan biosynthetic process

Reactome:R-HSA-2022928

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-8870732
Reactome:R-HSA-2750187
Reactome:R-HSA-2731122
Reactome:R-HSA-2684507
Reactome:R-HSA-2429643
Reactome:R-HSA-2423785
Reactome:R-HSA-2404131
Reactome:R-HSA-2024108
Reactome:R-HSA-2024084
Reactome:R-HSA-1678694

ECO:0000304

author statement supported by traceable reference used in manual assertion










C

Seeded From UniProt

complete

part_of

GO:0005796

Golgi lumen

Reactome:R-HSA-9036290
Reactome:R-HSA-9036289
Reactome:R-HSA-9036285
Reactome:R-HSA-9036283
Reactome:R-HSA-4420365
Reactome:R-HSA-3656267
Reactome:R-HSA-3656261
Reactome:R-HSA-3656257
Reactome:R-HSA-3656254
Reactome:R-HSA-3560804
Reactome:R-HSA-3560802
Reactome:R-HSA-2076611
Reactome:R-HSA-2076508
Reactome:R-HSA-2076419
Reactome:R-HSA-2076392
Reactome:R-HSA-2076383
Reactome:R-HSA-2024108
Reactome:R-HSA-2022919
Reactome:R-HSA-2022887
Reactome:R-HSA-2022860
Reactome:R-HSA-2022856
Reactome:R-HSA-2022851
Reactome:R-HSA-1889981
Reactome:R-HSA-1889978
Reactome:R-HSA-1889955
Reactome:R-HSA-1878002

ECO:0000304

author statement supported by traceable reference used in manual assertion


























C

Seeded From UniProt

complete

involved_in

GO:0001523

retinoid metabolic process

Reactome:R-HSA-975634

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Chung, JS et al. (2009) The DC-HIL/syndecan-4 pathway inhibits human allogeneic T-cell responses. Eur. J. Immunol. 39 965-74 PubMed GONUTS page
  2. ↑ 2.0 2.1 Baietti, MF et al. (2012) Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. Nat. Cell Biol. 14 677-85 PubMed GONUTS page
  3. ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  4. ↑ Nunes, SS et al. (2008) Syndecan-4 contributes to endothelial tubulogenesis through interactions with two motifs inside the pro-angiogenic N-terminal domain of thrombospondin-1. J. Cell. Physiol. 214 828-37 PubMed GONUTS page
  5. ↑ David, G et al. (1992) Molecular cloning of amphiglycan, a novel integral membrane heparan sulfate proteoglycan expressed by epithelial and fibroblastic cells. J. Cell Biol. 118 961-9 PubMed GONUTS page
  6. ↑ 6.0 6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ Dews, IC & Mackenzie, KR (2007) Transmembrane domains of the syndecan family of growth factor coreceptors display a hierarchy of homotypic and heterotypic interactions. Proc. Natl. Acad. Sci. U.S.A. 104 20782-7 PubMed GONUTS page
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