HUMAN:S39A4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SLC39A4 (synonyms: ZIP4)
Protein Name(s)	Zinc transporter ZIP4 Solute carrier family 39 member 4 Zrt- and Irt-like protein 4 ZIP-4
External Links
UniProt	Q6P5W5
EMBL	AK000334 AK025537 AF205589 BC001688 BC062625
CCDS	CCDS43782.1 CCDS6424.1
RefSeq	NP_060237.2 NP_570901.2
UniGene	Hs.521934
ProteinModelPortal	Q6P5W5
BioGrid	120769
STRING	9606.ENSP00000372700
TCDB	2.A.5.4.1
PhosphoSite	Q6P5W5
DMDM	296452970
MaxQB	Q6P5W5
PaxDb	Q6P5W5
PRIDE	Q6P5W5
Ensembl	ENST00000301305
GeneID	55630
KEGG	hsa:55630
UCSC	uc003zco.3 uc003zcp.3
CTD	55630
GeneCards	GC08M145637
H-InvDB	HIX0007856
HGNC	HGNC:17129
HPA	HPA031507
MIM	201100 607059
neXtProt	NX_Q6P5W5
Orphanet	37
PharmGKB	PA38204
eggNOG	COG0428
HOGENOM	HOG000293181
HOVERGEN	HBG062532
InParanoid	Q6P5W5
KO	K14710
PhylomeDB	Q6P5W5
TreeFam	TF318470
Reactome	REACT_20603
GenomeRNAi	55630
NextBio	60265
PRO	PR:Q6P5W5
Proteomes	UP000005640
Bgee	Q6P5W5
CleanEx	HS_SLC39A4
ExpressionAtlas	Q6P5W5
Genevestigator	Q6P5W5
GO	GO:0016324 GO:0016023 GO:0070062 GO:0016021 GO:0005886 GO:0055038 GO:0005385 GO:0034224 GO:0006882 GO:0055085
InterPro	IPR003689
Pfam	PF02535

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005385	zinc ion transmembrane transporter activity	PMID:22242765	ECO:0000314			F		Fig. 2A: Frog oocytes injected with human ZIP4 mRNA showed significant zinc ion uptake activity compared to a negative control.	complete CACAO 4499
enables	GO:0005385	zinc ion transmembrane transporter activity	PMID:22242765	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:14612438	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14612438	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071578	zinc ion import across plasma membrane		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036461 MGI:MGI:1914515 MGI:MGI:2139274 PANTHER:PTN000953562 UniProtKB:Q13433 UniProtKB:Q15043	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2139274 PANTHER:PTN001742843	P		Seeded From UniProt	complete
involved_in	GO:0006882	cellular zinc ion homeostasis		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036461 MGI:MGI:1914515 MGI:MGI:1919277 PANTHER:PTN000953562 UniProtKB:Q13433 UniProtKB:Q15043	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024236 PANTHER:PTN000953562 UniProtKB:Q13433 UniProtKB:Q15043	C		Seeded From UniProt	complete
enables	GO:0005385	zinc ion transmembrane transporter activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024236 FB:FBgn0036461 MGI:MGI:1914515 MGI:MGI:1919277 MGI:MGI:2139274 MGI:MGI:2384851 PANTHER:PTN000953562 UniProtKB:Q13433 UniProtKB:Q15043 UniProtKB:Q6P5W5	F		Seeded From UniProt	complete
involved_in	GO:0034224	cellular response to zinc ion starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q78IQ7 ensembl:ENSMUSP00000155442	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q78IQ7 ensembl:ENSMUSP00000155442	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003689	C		Seeded From UniProt	complete
involved_in	GO:0030001	metal ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003689	P		Seeded From UniProt	complete
enables	GO:0046873	metal ion transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003689	F		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003689	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-442422	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006829	zinc ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0864	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0055038	recycling endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0231	C		Seeded From UniProt	complete
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References

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