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HUMAN:S10AB
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | S100A11 (synonyms: MLN70, S100C) | |
| Protein Name(s) | Protein S100-A11
Calgizzarin Metastatic lymph node gene 70 protein MLN 70 Protein S100-C S100 calcium-binding protein A11 Protein S100-A11, N-terminally processed | |
| External Links | ||
| UniProt | P31949 | |
| EMBL | D38583 X80201 D49355 D50374 BT009912 AL591893 BC001410 BC014354 | |
| CCDS | CCDS1009.1 | |
| PIR | I37080 | |
| RefSeq | NP_005611.1 | |
| UniGene | Hs.417004 | |
| PDB | 1V4Z 1V50 2LUC | |
| PDBsum | 1V4Z 1V50 2LUC | |
| ProteinModelPortal | P31949 | |
| SMR | P31949 | |
| BioGrid | 112190 | |
| IntAct | P31949 | |
| MINT | MINT-5002556 | |
| STRING | 9606.ENSP00000271638 | |
| DrugBank | DB02482 | |
| iPTMnet | P31949 | |
| PhosphoSitePlus | P31949 | |
| SwissPalm | P31949 | |
| BioMuta | S100A11 | |
| DMDM | 1710818 | |
| DOSAC-COBS-2DPAGE | P31949 | |
| SWISS-2DPAGE | P31949 | |
| EPD | P31949 | |
| PaxDb | P31949 | |
| PeptideAtlas | P31949 | |
| PRIDE | P31949 | |
| TopDownProteomics | P31949 | |
| DNASU | 6282 | |
| Ensembl | ENST00000271638 | |
| GeneID | 6282 | |
| KEGG | hsa:6282 | |
| CTD | 6282 | |
| DisGeNET | 6282 | |
| GeneCards | S100A11 | |
| HGNC | HGNC:10488 | |
| HPA | CAB034320 HPA042745 | |
| MIM | 603114 | |
| neXtProt | NX_P31949 | |
| OpenTargets | ENSG00000163191 | |
| PharmGKB | PA34900 | |
| eggNOG | ENOG410J1U7 ENOG410YYVE | |
| GeneTree | ENSGT00760000119034 | |
| HOGENOM | HOG000246968 | |
| HOVERGEN | HBG001479 | |
| InParanoid | P31949 | |
| OMA | LIFMNTE | |
| OrthoDB | EOG091G10QT | |
| PhylomeDB | P31949 | |
| TreeFam | TF332727 | |
| Reactome | [www.reactome.org/content/detail/R-HSA-6798695 R-HSA-6798695] | |
| EvolutionaryTrace | P31949 | |
| GeneWiki | S100A11 | |
| GenomeRNAi | 6282 | |
| PRO | PR:P31949 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000163191 | |
| CleanEx | HS_S100A11 | |
| ExpressionAtlas | P31949 | |
| Genevisible | P31949 | |
| GO | GO:0005913 GO:0005737 GO:0070062 GO:0005576 GO:0005615 GO:0005634 GO:0001726 GO:0034774 GO:0098641 GO:0005509 GO:0048306 GO:0042803 GO:0044548 GO:0008285 GO:0008156 GO:0043312 GO:0007165 | |
| Gene3D | 1.10.238.10 | |
| InterPro | IPR011992 IPR018247 IPR002048 IPR001751 IPR013787 IPR028482 | |
| PANTHER | PTHR11639:SF85 | |
| Pfam | PF00036 PF01023 | |
| SMART | SM00054 SM01394 | |
| SUPFAM | SSF47473 | |
| PROSITE | PS00018 PS50222 PS00303 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0014911 |
positive regulation of smooth muscle cell migration |
ECO:0000315 |
P |
Organism: Homo sapiens. Protein Name: Protein S100-A11. Notes: Figure 4C is used. The paper states that “after the knockdown of t S100A11 expression, the cell migration induced by HIMF was significantly blocked (C).” Indeed, the corresponding chart does show that the relative area of the cells has significantly decreased upon mutation of S100A11. |
complete | |||||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0007318) |
Seeded From UniProt |
complete | ||
|
Colocalizes with |
GO:0005886 |
plasma membrane |
ECO:0000314 |
C |
Organism: Homo sapiens. Protein Name: Protein S100-A11. Notes: Figure 2 is used. As the notes say, “S100A11 is a cytosol protein, spotted and diffusely distributed in the resting cells (A). With continuing HIMF stimulation, S100A11 aggregated and translocated to the plasma membrane and the nucleus (B, C, and D).” Thus, S100A11 localizes with the plasma membrane. |
complete | ||||
|
enables |
GO:0098641 |
cadherin binding involved in cell-cell adhesion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
Colocalizes with |
GO:0005634 |
nucleus |
ECO:0000314 |
C |
Organism: Homo sapiens. Protein Name: Protein S100-A11. Notes: Figure 2 is used. As the notes say, “S100A11 is a cytosol protein, spotted and diffusely distributed in the resting cells (A). With continuing HIMF stimulation, S100A11 aggregated and translocated to the plasma membrane and the nucleus (B, C, and D).” Thus, S100A11 colocalizes with the nucleus. |
complete | ||||
|
part_of |
GO:0005913 |
cell-cell adherens junction |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
NOT |
GO:0048660 |
regulation of smooth muscle cell proliferation |
ECO:0000315 |
P |
Organism: Homo sapiens. Protein Name: Protein S100-A11. Notes: Figure 4D is used. According to the paper, “cell proliferation was evaluated by a direct cell counting assay using a hemocytometer... As shown in D, S100A11 knockdown did not affect the cell proliferation by HIMF.” The corresponding chart does indeed show that cell proliferation does not change much in comparison to other groups when treated with S100A11. |
complete | ||||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001831) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001914) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001827) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044548 |
S100 protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001726 |
ruffle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0098609 |
cell-cell adhesion |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0098641 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P50543 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008156 |
negative regulation of DNA replication |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034774 |
secretory granule lumen |
Reactome:R-HSA-6798748 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-6798748 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Fan, C et al. (2011) S100A11 mediates hypoxia-induced mitogenic factor (HIMF)-induced smooth muscle cell migration, vesicular exocytosis, and nuclear activation. Mol. Cell Proteomics 10 M110.000901 PubMed GONUTS page
- ↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
- ↑ 3.0 3.1 Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
- ↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
- ↑ Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Deloulme, JC et al. (2000) S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo. J. Biol. Chem. 275 35302-10 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Sakaguchi, M et al. (2000) Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts. J. Cell Biol. 149 1193-206 PubMed GONUTS page
- ↑ 10.0 10.1 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page
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