HUMAN:S100B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	S100B
Protein Name(s)	Protein S100-B S-100 protein beta chain S-100 protein subunit beta S100 calcium-binding protein B
External Links
UniProt	P04271
EMBL	M59488 M59487 CR542123 AP000339 CH471079 CH471079 CH471079 CH471079 BC001766
CCDS	CCDS13736.1
PIR	A38364
RefSeq	NP_006263.1
UniGene	Hs.422181
PDB	1MQ1 1UWO 2H61 2M49 2PRU 3CZT 3D0Y 3D10 3HCM
PDBsum	1MQ1 1UWO 2H61 2M49 2PRU 3CZT 3D0Y 3D10 3HCM
ProteinModelPortal	P04271
SMR	P04271
BioGrid	112193
IntAct	P04271
MINT	MINT-192546
STRING	9606.ENSP00000291700
BindingDB	P04271
ChEMBL	CHEMBL4300
DrugBank	DB00768
PhosphoSite	P04271
DMDM	134138
PaxDb	P04271
PeptideAtlas	P04271
PRIDE	P04271
DNASU	6285
Ensembl	ENST00000291700 ENST00000397648
GeneID	6285
KEGG	hsa:6285
UCSC	uc002zju.1
CTD	6285
GeneCards	GC21M048018
HGNC	HGNC:10500
HPA	CAB000073 CAB006825 HPA015768
MIM	176990
neXtProt	NX_P04271
PharmGKB	PA34912
eggNOG	NOG41158
GeneTree	ENSGT00760000119034
HOVERGEN	HBG001479
InParanoid	P04271
OMA	GDAECDF
OrthoDB	EOG7R833W
PhylomeDB	P04271
TreeFam	TF332727
Reactome	REACT_116022 REACT_118563 REACT_21281 REACT_24969 REACT_25195
ChiTaRS	S100B
EvolutionaryTrace	P04271
GeneWiki	S100B
GenomeRNAi	6285
NextBio	24405
PRO	PR:P04271
Proteomes	UP000005640
Bgee	P04271
CleanEx	HS_S100B
ExpressionAtlas	P04271
Genevestigator	P04271
GO	GO:0005737 GO:0005576 GO:0005615 GO:0043231 GO:0043025 GO:0005634 GO:0048471 GO:0001726 GO:0005509 GO:0048306 GO:0042802 GO:0042803 GO:0050786 GO:0044548 GO:0048156 GO:0008270 GO:0048708 GO:0007409 GO:0008283 GO:0071456 GO:0007417 GO:0045087 GO:0007611 GO:0060291 GO:0007613 GO:2001015 GO:0043065 GO:0008284 GO:0043123 GO:0008360 GO:0048168 GO:0051384 GO:0051597
Gene3D	1.10.238.10
InterPro	IPR011992 IPR018247 IPR002048 IPR028481 IPR001751 IPR013787
PANTHER	PTHR11639:SF17
Pfam	PF01023
PROSITE	PS00018 PS50222 PS00303

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0050786	RAGE receptor binding	PMID:15033494^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15109	F	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:15033494^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:12118070^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:10913138^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02638	F	Seeded From UniProt	complete
enables	GO:0044548	S100 protein binding	PMID:10913138^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04271	F	Seeded From UniProt	complete
enables	GO:0044548	S100 protein binding	PMID:9519411^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04271	F	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:15033494^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:9519411^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04271	F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:10913138^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02638	F	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P50114	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10913138^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02638	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10913138^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:9519411^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0001726	ruffle	PMID:10913138^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:27107012^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04271	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26871637^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04271	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25416956^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04271	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17660747^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04271	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:10913138^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04271	F	Seeded From UniProt	complete
involved_in	GO:2001015	negative regulation of skeletal muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	P	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	P	Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	P	Seeded From UniProt	complete
involved_in	GO:0051597	response to methylmercury	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	P	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	P	Seeded From UniProt	complete
involved_in	GO:0050806	positive regulation of synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	P	Seeded From UniProt	complete
enables	GO:0050786	RAGE receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	F	Seeded From UniProt	complete
involved_in	GO:0048708	astrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	F	Seeded From UniProt	complete
involved_in	GO:0031643	positive regulation of myelination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	P	Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	C	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04631 ensembl:ENSRNOP00000001743	F	Seeded From UniProt	complete
involved_in	GO:0048168	regulation of neuronal synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50114 ensembl:ENSMUSP00000047968	P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50114 ensembl:ENSMUSP00000047968	C	Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50114 ensembl:ENSMUSP00000047968	P	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50114 ensembl:ENSMUSP00000047968	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50114 ensembl:ENSMUSP00000047968	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50114 ensembl:ENSMUSP00000047968	C	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001751 InterPro:IPR002048 InterPro:IPR028481	F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028481	F	Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:8202493^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	PMID:8202493^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:8202493^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	Reactome:R-HSA-168249	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-997411 Reactome:R-HSA-8954179 Reactome:R-HSA-879411 Reactome:R-HSA-879377	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Hsieh, HL et al. (2004) S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells. Biochem. Biophys. Res. Commun. 316 949-59 PubMed GONUTS page
↑ Hsieh, HL et al. (2002) S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells. J. Cell. Sci. 115 3149-58 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Deloulme, JC et al. (2000) S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo. J. Biol. Chem. 275 35302-10 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Smith, SP & Shaw, GS (1998) A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form. Structure 6 211-22 PubMed GONUTS page
↑ Yachie, N et al. (2016) Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol. Syst. Biol. 12 863 PubMed GONUTS page
↑ Yang, X et al. (2016) Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell 164 805-17 PubMed GONUTS page
↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
↑ Ostendorp, T et al. (2007) Structural and functional insights into RAGE activation by multimeric S100B. EMBO J. 26 3868-78 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Reeves, RH et al. (1994) Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 91 5359-63 PubMed GONUTS page

[PMID:15033494-1] 1.0 ^1.1 ^1.2 Hsieh, HL et al. (2004) S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells. Biochem. Biophys. Res. Commun. 316 949-59 PubMed GONUTS page

[PMID:12118070-2] Hsieh, HL et al. (2002) S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells. J. Cell. Sci. 115 3149-58 PubMed GONUTS page

[PMID:10913138-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Deloulme, JC et al. (2000) S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo. J. Biol. Chem. 275 35302-10 PubMed GONUTS page

[PMID:9519411-4] 4.0 ^4.1 ^4.2 Smith, SP & Shaw, GS (1998) A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form. Structure 6 211-22 PubMed GONUTS page

[PMID:27107012-5] Yachie, N et al. (2016) Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol. Syst. Biol. 12 863 PubMed GONUTS page

[PMID:26871637-6] Yang, X et al. (2016) Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell 164 805-17 PubMed GONUTS page

[PMID:25416956-7] Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page

[PMID:17660747-8] Ostendorp, T et al. (2007) Structural and functional insights into RAGE activation by multimeric S100B. EMBO J. 26 3868-78 PubMed GONUTS page

[PMID:8202493-9] 9.0 ^9.1 ^9.2 Reeves, RH et al. (1994) Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 91 5359-63 PubMed GONUTS page

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HUMAN:S100B

Contents

Annotations

Notes

References

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