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HUMAN:RUBIC
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | KIAA0226 | |
| Protein Name(s) | Run domain Beclin-1 interacting and cysteine-rich containing protein
Rubicon Beclin-1 associated RUN domain containing protein Baron | |
| External Links | ||
| UniProt | Q92622 | |
| EMBL | D86979 AC024560 BX437131 BC014173 | |
| CCDS | CCDS43195.1 CCDS46987.1 | |
| RefSeq | NP_001139114.1 NP_055502.1 | |
| UniGene | Hs.478868 | |
| ProteinModelPortal | Q92622 | |
| BioGrid | 115062 | |
| IntAct | Q92622 | |
| STRING | 9606.ENSP00000296343 | |
| PhosphoSite | Q92622 | |
| DMDM | 296439479 | |
| MaxQB | Q92622 | |
| PaxDb | Q92622 | |
| PRIDE | Q92622 | |
| DNASU | 9711 | |
| Ensembl | ENST00000273582 ENST00000296343 | |
| GeneID | 9711 | |
| KEGG | hsa:9711 | |
| UCSC | uc003fyc.2 uc003fyd.3 | |
| CTD | 9711 | |
| GeneCards | GC03M197398 | |
| HGNC | HGNC:28991 | |
| HPA | HPA050908 HPA054497 | |
| MIM | 613516 615705 | |
| neXtProt | NX_Q92622 | |
| Orphanet | 404499 | |
| PharmGKB | PA134887849 | |
| eggNOG | NOG283042 | |
| GeneTree | ENSGT00550000074570 | |
| HOGENOM | HOG000113142 | |
| HOVERGEN | HBG062207 | |
| InParanoid | Q92622 | |
| OMA | FELHKCR | |
| OrthoDB | EOG7TMZR3 | |
| PhylomeDB | Q92622 | |
| TreeFam | TF317067 | |
| ChiTaRS | KIAA0226 | |
| GenomeRNAi | 9711 | |
| NextBio | 36499 | |
| Proteomes | UP000005640 | |
| Bgee | Q92622 | |
| CleanEx | HS_KIAA0226 | |
| ExpressionAtlas | Q92622 | |
| Genevestigator | Q92622 | |
| GO | GO:0005769 GO:0005770 GO:0005764 GO:0006914 GO:0006897 GO:0010507 GO:0045806 | |
| InterPro | IPR025258 IPR004012 | |
| Pfam | PF13901 PF02759 | |
| SMART | SM00593 | |
| PROSITE | PS50826 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0043553 |
negative regulation of phosphatidylinositol 3-kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901097 |
negative regulation of autophagosome maturation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045806 |
negative regulation of endocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010507 |
negative regulation of autophagy |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
NOT|colocalizes_with |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005770 |
late endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005769 |
early endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071985 |
multivesicular body sorting pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901097 |
negative regulation of autophagosome maturation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006897 |
endocytosis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006909 |
phagocytosis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005768 |
endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006914 |
autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005769 |
early endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005770 |
late endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Sun, Q et al. (2011) The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression. J. Biol. Chem. 286 185-91 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Matsunaga, K et al. (2009) Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat. Cell Biol. 11 385-96 PubMed GONUTS page
- ↑ 3.0 3.1 Metcalf, D & Isaacs, AM (2010) The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes. Biochem. Soc. Trans. 38 1469-73 PubMed GONUTS page
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