HUMAN:RSAD2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RSAD2 (ECO:0000312 with EMBL:EAX01034.1) (synonyms: CIG5 (ECO:0000312 with EMBL:AAY14802.1))
Protein Name(s)	Radical S-adenosyl methionine domain-containing protein 2 Cytomegalovirus-induced gene 5 protein Viperin Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
External Links
UniProt	Q8WXG1
EMBL	AF026941 AF442151 AC017076 CH471053 BC017969
CCDS	CCDS1656.1
RefSeq	NP_542388.2
UniGene	Hs.17518
ProteinModelPortal	Q8WXG1
BioGrid	124843
STRING	9606.ENSP00000371471
PhosphoSite	Q8WXG1
DMDM	74724033
PaxDb	Q8WXG1
PRIDE	Q8WXG1
DNASU	91543
Ensembl	ENST00000382040
GeneID	91543
KEGG	hsa:91543
UCSC	uc002qyp.1
CTD	91543
GeneCards	GC02P007005
HGNC	HGNC:30908
HPA	HPA041160
MIM	607810
neXtProt	NX_Q8WXG1
PharmGKB	PA134937442
eggNOG	NOG72023
GeneTree	ENSGT00390000013670
HOGENOM	HOG000194793
HOVERGEN	HBG053099
InParanoid	Q8WXG1
KO	K15045
OMA	CLLIEGE
PhylomeDB	Q8WXG1
TreeFam	TF300085
ChiTaRS	RSAD2
GenomeRNAi	91543
NextBio	77284
PRO	PR:Q8WXG1
Proteomes	UP000005640
Bgee	Q8WXG1
CleanEx	HS_RSAD2
ExpressionAtlas	Q8WXG1
Genevestigator	Q8WXG1
GO	GO:0005783 GO:0005789 GO:0005794 GO:0005811 GO:0005743 GO:0005741 GO:0005739 GO:0051539 GO:0003824 GO:0046872 GO:0043621 GO:0035710 GO:0043367 GO:0051607 GO:0045087 GO:0050709 GO:0045071 GO:0001503 GO:2000553 GO:0034157 GO:0034165 GO:0030278 GO:0009615 GO:0016032
Gene3D	3.20.20.70
InterPro	IPR013785 IPR006638 IPR007197 IPR026372
Pfam	PF04055
SMART	SM00729
TIGRFAMs	TIGR04278

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:2000553	positive regulation of T-helper 2 cell cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8CBB9	P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:16108059^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:16982913^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:9391139^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding	PMID:20176015^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0050709	negative regulation of protein secretion	PMID:19074433^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045071	negative regulation of viral genome replication	PMID:21957124^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043621	protein self-association	PMID:19074433^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043367	CD4-positive, alpha-beta T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8CBB9	P	Seeded From UniProt	complete
	GO:0002230	positive regulation of defense response to virus by host	PMID:23160199^[7]	ECO:0000314			P	As seen in figure 7, researchers investigated whether loss of viperin expression affects type I IFN–mediated antiviral response by pretreating WT and Rsad2–/– fibroblasts with type I IFNs for 4 hours prior to CHIKV infection. Both IFN-α and IFN-β effectively inhibited CHIKV infection and replication to a comparable level in WT and Rsad2–/– fibroblasts, which demonstrated the importance of type I IFNs in limiting CHIKV infection.	complete CACAO 6886
involved_in	GO:0035710	CD4-positive, alpha-beta T cell activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8CBB9	P	Seeded From UniProt	complete
involved_in	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8CBB9	P	Seeded From UniProt	complete
involved_in	GO:0034157	positive regulation of toll-like receptor 7 signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8CBB9	P	Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:21957124^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8CBB9	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:19074433^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21527675^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:11752458^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:21527675^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:21527675^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21527675^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0001650	fibrillar center	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2000553	positive regulation of T-helper 2 cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CBB9 ensembl:ENSMUSP00000020970	P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CBB9 ensembl:ENSMUSP00000020970	P	Seeded From UniProt	complete
involved_in	GO:0045071	negative regulation of viral genome replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CBB9 ensembl:ENSMUSP00000020970	P	Seeded From UniProt	complete
involved_in	GO:0043367	CD4-positive, alpha-beta T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CBB9 ensembl:ENSMUSP00000020970	P	Seeded From UniProt	complete
involved_in	GO:0035710	CD4-positive, alpha-beta T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CBB9 ensembl:ENSMUSP00000020970	P	Seeded From UniProt	complete
involved_in	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CBB9 ensembl:ENSMUSP00000020970	P	Seeded From UniProt	complete
involved_in	GO:0034157	positive regulation of toll-like receptor 7 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CBB9 ensembl:ENSMUSP00000020970	P	Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CBB9 ensembl:ENSMUSP00000020970	P	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CBB9 ensembl:ENSMUSP00000020970	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CBB9 ensembl:ENSMUSP00000020970	C	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006638 InterPro:IPR007197 InterPro:IPR013785	F	Seeded From UniProt	complete
enables	GO:0051536	iron-sulfur cluster binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006638 InterPro:IPR007197	F	Seeded From UniProt	complete
involved_in	GO:0060337	type I interferon signaling pathway	Reactome:R-HSA-909733	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-1015702	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
enables	GO:0051536	iron-sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0411	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0004	F	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0551 UniProtKB-SubCell:SL-0154	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0999 UniProtKB-SubCell:SL-0168	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Helbig, KJ et al. (2005) Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. Hepatology 42 702-10 PubMed GONUTS page
↑ Rivieccio, MA et al. (2006) TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5. J. Immunol. 177 4735-41 PubMed GONUTS page
↑ Zhu, H et al. (1997) Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs. Proc. Natl. Acad. Sci. U.S.A. 94 13985-90 PubMed GONUTS page
↑ Duschene, KS & Broderick, JB (2010) The antiviral protein viperin is a radical SAM enzyme. FEBS Lett. 584 1263-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Hinson, ER & Cresswell, P (2009) The N-terminal amphipathic alpha-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibits protein secretion. J. Biol. Chem. 284 4705-12 PubMed GONUTS page
↑ ^6.0 ^6.1 Wang, S et al. (2012) Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33. J. Gen. Virol. 93 83-92 PubMed GONUTS page
↑ Teng, TS et al. (2012) Viperin restricts chikungunya virus replication and pathology. J. Clin. Invest. 122 4447-60 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Seo, JY et al. (2011) Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity. Science 332 1093-7 PubMed GONUTS page
↑ Chin, KC & Cresswell, P (2001) Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. Proc. Natl. Acad. Sci. U.S.A. 98 15125-30 PubMed GONUTS page

[PMID:16108059-1] Helbig, KJ et al. (2005) Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. Hepatology 42 702-10 PubMed GONUTS page

[PMID:16982913-2] Rivieccio, MA et al. (2006) TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5. J. Immunol. 177 4735-41 PubMed GONUTS page

[PMID:9391139-3] Zhu, H et al. (1997) Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs. Proc. Natl. Acad. Sci. U.S.A. 94 13985-90 PubMed GONUTS page

[PMID:20176015-4] Duschene, KS & Broderick, JB (2010) The antiviral protein viperin is a radical SAM enzyme. FEBS Lett. 584 1263-7 PubMed GONUTS page

[PMID:19074433-5] 5.0 ^5.1 ^5.2 Hinson, ER & Cresswell, P (2009) The N-terminal amphipathic alpha-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibits protein secretion. J. Biol. Chem. 284 4705-12 PubMed GONUTS page

[PMID:21957124-6] 6.0 ^6.1 Wang, S et al. (2012) Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33. J. Gen. Virol. 93 83-92 PubMed GONUTS page

[PMID:23160199-7] Teng, TS et al. (2012) Viperin restricts chikungunya virus replication and pathology. J. Clin. Invest. 122 4447-60 PubMed GONUTS page

[PMID:21527675-8] 8.0 ^8.1 ^8.2 ^8.3 Seo, JY et al. (2011) Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity. Science 332 1093-7 PubMed GONUTS page

[PMID:11752458-9] Chin, KC & Cresswell, P (2001) Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. Proc. Natl. Acad. Sci. U.S.A. 98 15125-30 PubMed GONUTS page

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HUMAN:RSAD2

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