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HUMAN:RRN3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | RRN3 (synonyms: TIFIA) | |
| Protein Name(s) | RNA polymerase I-specific transcription initiation factor RRN3
Transcription initiation factor IA TIF-IA | |
| External Links | ||
| UniProt | Q9NYV6 | |
| EMBL | AJ272050 AF227156 AK303405 AK304856 AK314769 AC139256 CH471301 BC071868 BC104660 BC132688 BC132690 | |
| CCDS | CCDS10559.1 | |
| RefSeq | NP_060897.3 | |
| UniGene | Hs.460078 Hs.720348 | |
| ProteinModelPortal | Q9NYV6 | |
| BioGrid | 120102 | |
| IntAct | Q9NYV6 | |
| MINT | MINT-249163 | |
| STRING | 9606.ENSP00000198767 | |
| iPTMnet | Q9NYV6 | |
| PhosphoSitePlus | Q9NYV6 | |
| BioMuta | RRN3 | |
| DMDM | 74719591 | |
| EPD | Q9NYV6 | |
| MaxQB | Q9NYV6 | |
| PaxDb | Q9NYV6 | |
| PeptideAtlas | Q9NYV6 | |
| PRIDE | Q9NYV6 | |
| DNASU | 54700 | |
| Ensembl | ENST00000198767 ENST00000327307 ENST00000564131 ENST00000616334 ENST00000632541 ENST00000634151 | |
| GeneID | 54700 | |
| KEGG | hsa:54700 | |
| UCSC | uc002dde.4 | |
| CTD | 54700 | |
| DisGeNET | 54700 | |
| GeneCards | RRN3 | |
| H-InvDB | HIX0012886 HIX0038660 HIX0038739 | |
| HGNC | HGNC:30346 | |
| HPA | HPA049837 | |
| MIM | 605121 | |
| neXtProt | NX_Q9NYV6 | |
| OpenTargets | ENSG00000085721 | |
| PharmGKB | PA134878601 | |
| eggNOG | KOG2434 ENOG410XRJJ | |
| GeneTree | ENSGT00390000001488 | |
| HOGENOM | HOG000132846 | |
| HOVERGEN | HBG056994 | |
| InParanoid | Q9NYV6 | |
| KO | K15216 | |
| OMA | IQVDMED | |
| OrthoDB | EOG091G089T | |
| PhylomeDB | Q9NYV6 | |
| TreeFam | TF312979 | |
| Reactome | [www.reactome.org/content/detail/R-HSA-73762 R-HSA-73762] [www.reactome.org/content/detail/R-HSA-73772 R-HSA-73772] | |
| SIGNOR | Q9NYV6 | |
| GeneWiki | RRN3 | |
| GenomeRNAi | 54700 | |
| PRO | PR:Q9NYV6 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000085721 | |
| CleanEx | HS_RRN3 | |
| ExpressionAtlas | Q9NYV6 | |
| Genevisible | Q9NYV6 | |
| GO | GO:0005730 GO:0005654 GO:0005634 GO:0001042 GO:0001164 GO:0001181 GO:0008283 GO:0007028 GO:0048872 GO:0001701 GO:1902254 GO:0007000 GO:0010976 GO:0045893 GO:2000142 GO:0042254 GO:0006361 GO:0001180 | |
| Gene3D | 1.25.10.10 | |
| InterPro | IPR011989 IPR007991 | |
| PANTHER | PTHR12790 | |
| Pfam | PF05327 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0001164 |
RNA polymerase I CORE element sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006361 |
transcription initiation from RNA polymerase I promoter |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1925255 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000300504 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001181 |
RNA polymerase I general transcription initiation factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000300504 |
F |
Seeded From UniProt |
complete | ||
| GO:0005730 |
nucleolus |
ECO:0000314 |
C |
Organism: Homo sapiens. Protein Name: RNA polymerase I-specific transcription initiation factor RRN3/TIF-IA. Notes: Figure 6B is used. MCF-7 cells (which are human) have their nucleoli stained red and are also immunostained so that RRN3 will appear green. As can be seen in the micrograph control groups, there is significant overlap of these colors. There thus appears to be a non-transient link between RRN3 and the nucleolus. |
complete | |||||
|
enables |
GO:0001042 |
RNA polymerase I core binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000300504 |
F |
Seeded From UniProt |
complete | ||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Organism: Homo sapiens. Protein Name: RNA polymerase I-specific transcription initiation factor RRN3/TIF-IA. Notes: Figure 6B is used. MCF-7 cells (which are human) have their nuclei stained blue and are also immunostained so that RRN3 will appear green. As can be seen in the micrograph control groups, there is significant overlap of these colors. There thus appears to be a non-transient link between RRN3 and the nucleus. |
complete | |||||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001188 |
RNA polymerase I preinitiation complex assembly |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0001164 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010976 |
positive regulation of neuron projection development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2GV13 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000142 |
regulation of DNA-templated transcription, initiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2RS91 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902254 |
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2RS91 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070063 |
RNA polymerase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2RS91 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048872 |
homeostasis of number of cells |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2RS91 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2RS91 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042254 |
ribosome biogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2RS91 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008283 |
cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2RS91 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007028 |
cytoplasm organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2RS91 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007000 |
nucleolus organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2RS91 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006361 |
transcription initiation from RNA polymerase I promoter |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2RS91 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006352 |
DNA-templated transcription, initiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2RS91 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001701 |
in utero embryonic development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2RS91 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006361 |
transcription initiation from RNA polymerase I promoter |
Reactome:R-HSA-73772 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-73769 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Zhai, N et al. (2012) Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis. J Mol Cell Biol 4 231-41 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 Lewinska, A et al. (2017) Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation. Redox Biol 12 469-482 PubMed GONUTS page
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- GO:2000142 ! regulation of DNA-templated transcription initiation
- GO:0042254 ! ribosome biogenesis
- GO:0001188 ! RNA polymerase I preinitiation complex assembly
- GO:0001042 ! RNA polymerase I core binding
- GO:0070063 ! RNA polymerase binding
- GO:0001181 ! RNA polymerase I general transcription initiation factor activity
- GO:0001164 ! RNA polymerase I core promoter sequence-specific DNA binding
