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HUMAN:RPP21

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RPP21 (synonyms: C6orf135, CAT60)
Protein Name(s) Ribonuclease P protein subunit p21

RNaseP protein p21 Ribonuclease P/MRP 21 kDa subunit Ribonucleoprotein V

External Links
UniProt Q9H633
EMBL AF212152
AJ504713
AJ504714
AJ504715
AJ504716
AK026291
AL662832
AL662832
AL662832
AL662795
AL662795
AL773535
AL773535
AL662795
BX294158
BX294158
BX294158
BX294158
CR759928
CR759928
BX927214
BX927214
BX927214
CR759281
CR759281
CH471081
CH471081
CH471081
BC011730
BI598757
CCDS CCDS4679.1
CCDS56409.1
CCDS56410.1
RefSeq NP_001186049.1
NP_001186050.1
NP_079115.1
UniGene Hs.183232
ProteinModelPortal Q9H633
SMR Q9H633
BioGrid 122981
IntAct Q9H633
PhosphoSite Q9H633
DMDM 52001252
MaxQB Q9H633
PaxDb Q9H633
PRIDE Q9H633
DNASU 79897
Ensembl ENST00000376642
ENST00000411784
ENST00000414187
ENST00000415583
ENST00000416977
ENST00000424616
ENST00000425575
ENST00000428040
ENST00000430900
ENST00000433076
ENST00000434282
ENST00000435318
ENST00000436442
ENST00000437470
ENST00000442966
ENST00000455025
GeneID 79897
KEGG hsa:79897
UCSC uc003nqd.2
uc003nqe.2
uc003nqf.2
uc021yuc.1
CTD 79897
GeneCards GC06P030312
GC06Pi30321
GC06Pj30302
GC06Pk30303
GC06Pl30357
GC06Pn30302
GC06Po30302
H-InvDB HIX0207610
HIX0207675
HIX0207761
HGNC HGNC:21300
HPA HPA048369
HPA049389
MIM 612524
neXtProt NX_Q9H633
PharmGKB PA134960979
eggNOG NOG285045
GeneTree ENSGT00390000003020
HOVERGEN HBG055987
InParanoid Q9H633
KO K03540
OMA DPKHLLW
OrthoDB EOG75MVZT
PhylomeDB Q9H633
GenomeRNAi 79897
NextBio 69734
PRO PR:Q9H633
Proteomes UP000005640
UP000005640
Bgee Q9H633
CleanEx HS_RPP21
Genevestigator Q9H633
GO GO:0005730
GO:0046872
GO:0004526
GO:0042493
GO:0008033
InterPro IPR007175
PANTHER PTHR14742
Pfam PF04032

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0033204

ribonuclease P RNA binding

PMID:30454648[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0030681

multimeric ribonuclease P complex

PMID:30454648[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

contributes_to

GO:0004526

ribonuclease P activity

PMID:30454648[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001682

tRNA 5'-leader removal

PMID:30454648[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:18291362[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008033

tRNA processing

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000380878
SGD:S000001454

P

Seeded From UniProt

complete

part_of

GO:0005655

nucleolar ribonuclease P complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000380877
SGD:S000001454

C

Seeded From UniProt

complete

contributes_to

GO:0004526

ribonuclease P activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000380877
SGD:S000001454
UniProtKB:Q9H633

F

Seeded From UniProt

complete

involved_in

GO:0001682

tRNA 5'-leader removal

PMID:16723659[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

contributes_to

GO:0004526

ribonuclease P activity

PMID:16723659[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0030681

multimeric ribonuclease P complex

PMID:16723659[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0090501

RNA phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004526

P

Seeded From UniProt

complete

involved_in

GO:0090501

RNA phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004526

P

Seeded From UniProt

complete

involved_in

GO:0090501

RNA phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004526

P

Seeded From UniProt

complete

involved_in

GO:0090501

RNA phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004526

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004526

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004526

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004526

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004526

P

Seeded From UniProt

complete

enables

GO:0004526

ribonuclease P activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.26.5

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6791223
Reactome:R-HSA-5696810

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0001682

tRNA 5'-leader removal

Reactome:R-HSA-5696810

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008033

tRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0819

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Wu, J et al. (2018) Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Cell 175 1393-1404.e11 PubMed GONUTS page
  2. ↑ Han, A et al. (2008) Sulindac suppresses beta-catenin expression in human cancer cells. Eur. J. Pharmacol. 583 26-31 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Welting, TJ et al. (2006) Differential association of protein subunits with the human RNase MRP and RNase P complexes. RNA 12 1373-82 PubMed GONUTS page
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