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HUMAN:RILP

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RILP
Protein Name(s) Rab-interacting lysosomal protein
External Links
UniProt Q96NA2
EMBL AJ404317
AK055755
AK314767
AF370391
AJ278711
BC004961
BC031621
CCDS CCDS11009.1
RefSeq NP_113618.2
UniGene Hs.534497
PDB 1YHN
PDBsum 1YHN
ProteinModelPortal Q96NA2
SMR Q96NA2
BioGrid 123679
IntAct Q96NA2
STRING 9606.ENSP00000301336
PhosphoSite Q96NA2
DMDM 74732524
MaxQB Q96NA2
PaxDb Q96NA2
PRIDE Q96NA2
DNASU 83547
Ensembl ENST00000301336
ENST00000622136
GeneID 83547
KEGG hsa:83547
UCSC uc002ftd.3
CTD 83547
GeneCards GC17M001549
HGNC HGNC:30266
HPA HPA052041
MIM 607848
neXtProt NX_Q96NA2
PharmGKB PA134915969
eggNOG NOG28812
GeneTree ENSGT00530000063269
HOGENOM HOG000007529
HOVERGEN HBG082629
InParanoid Q96NA2
KO K13883
OMA EPEWATA
PhylomeDB Q96NA2
TreeFam TF313489
Reactome REACT_121399
EvolutionaryTrace Q96NA2
GeneWiki RILP_(gene)
GenomeRNAi 83547
NextBio 72481
PRO PR:Q96NA2
Proteomes UP000005640
UP000005640
Bgee Q96NA2
CleanEx HS_RILP
ExpressionAtlas Q96NA2
Genevestigator Q96NA2
GO GO:0005770
GO:0031902
GO:0005765
GO:0005764
GO:0005739
GO:0030670
GO:0043234
GO:0017137
GO:0019886
GO:0008333
GO:0015031
InterPro IPR019143
IPR021563
Pfam PF09744
PF11461

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0017137

Rab GTPase binding

PMID:18272684[1]

ECO:0000021

physical interaction evidence

UniProtKB:P18067


F

Figure. 4 : Using the two-hybrid assays ;the wild type of Rab7 and the CMT2B-associated Rab7 mutants were interacting strongly with RILP .Also Rab7 Q67L (which is an active mutated Rab7 protein impaired in GTP hydrolysis not GTP binding ) showed a strong interaction with RILP compared to the interaction of the dominant-negative mutant Rab7 T22N which was extremely weak .

complete

GO:0005770

late endosome

PMID:18272684[1]

ECO:0000314

direct assay evidence used in manual assertion

C

(Figure. 6M–X): When co-expressed with RILP,the Rab7 wild type, Rab7 Q67L and the CMT2B-associated Rab7 mutant proteins were present on the clustered endosomal structures. Which indicates that Rab7 not only interacts with RILP but it also colocalizes with RILP.

complete

enables

GO:0031267

small GTPase binding

PMID:26911690[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P51149

F

Seeded From UniProt

complete

involved_in

GO:0032509

endosome transport via multivesicular body sorting pathway

PMID:17010938[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

PMID:17010938[3]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(GO:0048471)

Seeded From UniProt

complete

involved_in

GO:0070676

intralumenal vesicle formation

PMID:17959629[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(GO:0005770)

Seeded From UniProt

complete

involved_in

GO:0045732

positive regulation of protein catabolic process

PMID:17959629[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045022

early endosome to late endosome transport

PMID:17959629[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_direct_input:(UniProtKB:P00533)

Seeded From UniProt

complete

involved_in

GO:0042177

negative regulation of protein catabolic process

PMID:17010938[3]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(UniProtKB:P01133)

Seeded From UniProt

complete

involved_in

GO:0010796

regulation of multivesicular body size

PMID:17010938[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0017137

Rab GTPase binding

PMID:18272684[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P51149

F

Seeded From UniProt

complete

involved_in

GO:0008333

endosome to lysosome transport

PMID:18272684[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

PMID:18272684[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

PMID:18272684[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

PMID:11179213[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

PMID:11179213[5]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005765

lysosomal membrane

PMID:11179213[5]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1914311
PANTHER:PTN000948208
UniProtKB:Q86YF9
UniProtKB:Q8IYY4

P

Seeded From UniProt

complete

enables

GO:0051959

dynein light intermediate chain binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001088590
UniProtKB:Q96NA2

F

Seeded From UniProt

complete

involved_in

GO:0045022

early endosome to late endosome transport

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001088606
UniProtKB:Q96NA2

P

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1914311
PANTHER:PTN000948208
UniProtKB:Q86YF9
UniProtKB:Q8IYY4

C

Seeded From UniProt

complete

enables

GO:0031267

small GTPase binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001088590
UniProtKB:Q96NA2

F

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001088606
UniProtKB:Q96NA2

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1914311
PANTHER:PTN001469871
UniProtKB:Q86YF9

C

Seeded From UniProt

complete

enables

GO:0051959

dynein light intermediate chain binding

PMID:25272277[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9Y6G9

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0045022

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0045022

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5ND29
ensembl:ENSMUSP00000037238

C

Seeded From UniProt

complete

enables

GO:0046983

protein dimerization activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021563

F

Seeded From UniProt

complete

enables

GO:0017137

Rab GTPase binding

PMID:11179213[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0019886

antigen processing and presentation of exogenous peptide antigen via MHC class II

Reactome:R-HSA-2132295

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005765

lysosomal membrane

Reactome:R-HSA-2213248

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0458

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

part_of

GO:0005765

lysosomal membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0157

C

Seeded From UniProt

complete

part_of

GO:0031902

late endosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0151

C

Seeded From UniProt

complete

part_of

GO:0030670

phagocytic vesicle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0205

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Spinosa, MR et al. (2008) Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease. J. Neurosci. 28 1640-8 PubMed GONUTS page
  2. ↑ Song, P et al. (2016) Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway. J. Neurosci. 36 2425-37 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Wang, T & Hong, W (2006) RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment. Biochem. Biophys. Res. Commun. 350 413-23 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Progida, C et al. (2007) RILP is required for the proper morphology and function of late endosomes. J. Cell. Sci. 120 3729-37 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Cantalupo, G et al. (2001) Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. EMBO J. 20 683-93 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ Schroeder, CM et al. (2014) A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region. Elife 3 e03351 PubMed GONUTS page
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