HUMAN:RGS6

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RGS6
Protein Name(s)	Regulator of G-protein signaling 6 RGS6 S914
External Links
UniProt	P49758
EMBL	AF073920 AF073921 AY309097 AY309098 AY309099 AY309100 AF465727 AF465711 AF465712 AF465713 AF465714 AF465715 AF465716 AF465717 AF465718 AF465719 AF465720 AF465721 AF465722 AF465723 AF465724 AF465725 AF465726 AF465727 AF465711 AF465712 AF465713 AF465714 AF465715 AF465716 AF465717 AF465718 AF465719 AF465720 AF465721 AF465722 AF465723 AF465724 AF465725 AF465726 AF465726 AF465711 AF465712 AF465713 AF465714 AF465715 AF465716 AF465717 AF465718 AF465719 AF465720 AF465721 AF465722 AF465723 AF465724 AF465725 AF465727 AF465711 AF465712 AF465713 AF465714 AF465715 AF465716 AF465717 AF465718 AF465719 AF465720 AF465721 AF465723 AF465724 AF465725 AF465726 AF465727 AF465711 AF465712 AF465713 AF465714 AF465715 AF465716 AF465717 AF465718 AF465719 AF465720 AF465721 AF465723 AF465724 AF465725 AF465726 AF465727 AF465711 AF465712 AF465713 AF465714 AF465715 AF465716 AF465717 AF465718 AF465719 AF465720 AF465721 AF465722 AF465723 AF465724 AF465725 AF465727 AF465711 AF465712 AF465713 AF465714 AF465715 AF465716 AF465717 AF465718 AF465719 AF465720 AF465721 AF465722 AF465723 AF465724 AF465725 AF465727 AF465711 AF465712 AF465713 AF465714 AF465715 AF465716 AF465717 AF465718 AF465719 AF465720 AF465721 AF465723 AF465724 AF465725 AF465727 AF465711 AF465712 AF465713 AF465714 AF465715 AF465716 AF465717 AF465718 AF465719 AF465720 AF465721 AF465723 AF465724 AF465725 AF465726 AF465711 AF465712 AF465713 AF465714 AF465715 AF465716 AF465717 AF465718 AF465719 AF465720 AF465721 AF465723 AF465724 AF465725 AF107619 AF107620 AF156932 AC004828 AC005157 AC005226 AC005227 AC005477 AC005533 AC005857 AC005993 L40394
CCDS	CCDS55924.1 CCDS9808.1
RefSeq	NP_001191345.1 NP_001191346.1 NP_001191347.1 NP_001191348.1 NP_001191349.1 NP_001191350.1 NP_001191351.1 NP_001191352.1 NP_001191353.1 NP_004287.3 XP_005268291.1 XP_005268292.1 XP_005268293.1 XP_006720391.1 XP_006720392.1 XP_006720393.1 XP_006720394.1 XP_006720395.1 XP_006720396.1
UniGene	Hs.509872
PDB	2ES0
PDBsum	2ES0
ProteinModelPortal	P49758
SMR	P49758
BioGrid	114987
IntAct	P49758
MINT	MINT-242744
PhosphoSite	P49758
DMDM	215274268
PaxDb	P49758
PRIDE	P49758
DNASU	9628
Ensembl	ENST00000355512 ENST00000404301 ENST00000406236 ENST00000407322 ENST00000553525 ENST00000553530 ENST00000554474 ENST00000554782 ENST00000555571 ENST00000556437
GeneID	9628
KEGG	hsa:9628
UCSC	uc001xmx.4 uc001xmy.4 uc021rvw.1 uc021rvx.1 uc021rvy.1 uc021rvz.1 uc021rwa.1 uc021rwb.1 uc021rwc.1
CTD	9628
GeneCards	GC14P072399
HGNC	HGNC:10002
HPA	HPA003067
MIM	603894
neXtProt	NX_P49758
PharmGKB	PA34377
eggNOG	NOG327614
GeneTree	ENSGT00760000119142
HOVERGEN	HBG007404
InParanoid	P49758
KO	K16449
OMA	YEDAQDH
OrthoDB	EOG7BZVS5
PhylomeDB	P49758
TreeFam	TF351956
Reactome	REACT_19231
ChiTaRS	RGS6
EvolutionaryTrace	P49758
GeneWiki	RGS6
GenomeRNAi	9628
NextBio	36131
PRO	PR:P49758
Proteomes	UP000005640
Bgee	P49758
ExpressionAtlas	P49758
Genevestigator	P49758
GO	GO:0005737 GO:0005794 GO:0005834 GO:0005886 GO:0005096 GO:0004871 GO:0007186 GO:0035556 GO:0043547 GO:0045666 GO:0008277 GO:0038032
Gene3D	1.10.10.10 1.10.196.10 4.10.260.10
InterPro	IPR000591 IPR015898 IPR016137 IPR024066 IPR011991
Pfam	PF00610 PF00631 PF00615
PRINTS	PR01301
SMART	SM00049 SM00224 SM00315
SUPFAM	SSF48097 SSF48670
PROSITE	PS50186 PS50132

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0043547	positive regulation of GTPase activity	PMID:10521509^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:10521509^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0019898	extrinsic component of membrane	PMID:10521509^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:10521509^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037956	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015898 InterPro:IPR036284	P	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000591	P	Seeded From UniProt	complete
involved_in	GO:0008277	regulation of G protein-coupled receptor signaling pathway	PMID:10083744^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:10083744^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8982020 Reactome:R-HSA-8982019 Reactome:R-HSA-8982012	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	Reactome:R-HSA-8982020	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0343	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0734	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Posner, BA et al. (1999) Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways. J. Biol. Chem. 274 31087-93 PubMed GONUTS page
↑ ^2.0 ^2.1 Seki, N et al. (1999) The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3. J. Hum. Genet. 44 138-40 PubMed GONUTS page

[PMID:10521509-1] 1.0 ^1.1 ^1.2 ^1.3 Posner, BA et al. (1999) Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways. J. Biol. Chem. 274 31087-93 PubMed GONUTS page

[PMID:10083744-2] 2.0 ^2.1 Seki, N et al. (1999) The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3. J. Hum. Genet. 44 138-40 PubMed GONUTS page

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HUMAN:RGS6

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