HUMAN:RGS2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RGS2 (synonyms: G0S8)
Protein Name(s)	Regulator of G-protein signaling 2 RGS2 Cell growth-inhibiting gene 31 protein G0/G1 switch regulatory protein 8
External Links
UniProt	P41220
EMBL	L13391 L13463 AF493926 AY971351 AK313668 BT007065 CR457410 AL035407 CH471067 BC007049
CCDS	CCDS1377.1
PIR	I53020
RefSeq	NP_002914.1
UniGene	Hs.78944
PDB	2AF0 2V4Z 4EKC 4EKD
PDBsum	2AF0 2V4Z 4EKC 4EKD
ProteinModelPortal	P41220
SMR	P41220
BioGrid	111929
DIP	DIP-44289N
IntAct	P41220
MINT	MINT-1380095
STRING	9606.ENSP00000235382
PhosphoSite	P41220
DMDM	729545
MaxQB	P41220
PaxDb	P41220
PRIDE	P41220
DNASU	5997
Ensembl	ENST00000235382
GeneID	5997
KEGG	hsa:5997
UCSC	uc001gsl.3
CTD	5997
GeneCards	GC01P192778
HGNC	HGNC:9998
HPA	HPA013385
MIM	600861
neXtProt	NX_P41220
PharmGKB	PA34372
eggNOG	NOG252352
GeneTree	ENSGT00760000118903
HOGENOM	HOG000233512
HOVERGEN	HBG013233
InParanoid	P41220
KO	K18154
OMA	QQAFIKP
OrthoDB	EOG7VHSZ5
PhylomeDB	P41220
TreeFam	TF315837
Reactome	REACT_18283
ChiTaRS	RGS2
EvolutionaryTrace	P41220
GeneWiki	RGS2
GenomeRNAi	5997
NextBio	23371
PRO	PR:P41220
Proteomes	UP000005640
Bgee	P41220
CleanEx	HS_RGS2
ExpressionAtlas	P41220
Genevestigator	P41220
GO	GO:0005737 GO:0009898 GO:0005829 GO:0005739 GO:0043005 GO:0005730 GO:0005886 GO:0005516 GO:0005096 GO:0050873 GO:0007049 GO:0043951 GO:0010614 GO:0045744 GO:0043407 GO:0010519 GO:0060452 GO:0031116 GO:0071877 GO:0008277 GO:0006417 GO:0055119 GO:0060087 GO:0007283 GO:0038032
Gene3D	1.10.196.10
InterPro	IPR016137 IPR024066
Pfam	PF00615
PRINTS	PR01301
SMART	SM00315
SUPFAM	SSF48097
PROSITE	PS50132

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005634	nucleus	PMID:10791963^[1]	ECO:0000314			C	Fig.2	complete CACAO 6946
enables	GO:0001965	G-protein alpha-subunit binding	PMID:19478087^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21279	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11278586^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11278586^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11278586^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008277	regulation of G protein-coupled receptor signaling pathway	PMID:19478087^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:19478087^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10791963^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0140194	negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08849	P	Seeded From UniProt	complete
involved_in	GO:0060452	positive regulation of cardiac muscle contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08849	P	Seeded From UniProt	complete
involved_in	GO:0055119	relaxation of cardiac muscle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08849	P	Seeded From UniProt	complete
involved_in	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08849	P	Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08849	P	Seeded From UniProt	complete
involved_in	GO:0010614	negative regulation of cardiac muscle hypertrophy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08849	P	Seeded From UniProt	complete
involved_in	GO:0010519	negative regulation of phospholipase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08849	P	Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08849	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08849	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P	Seeded From UniProt	complete
involved_in	GO:0140194	negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0060452	positive regulation of cardiac muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0060087	relaxation of vascular smooth muscle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0055119	relaxation of cardiac muscle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0050873	brown fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0043951	negative regulation of cAMP-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0010614	negative regulation of cardiac muscle hypertrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0010519	negative regulation of phospholipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	C	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	C	Seeded From UniProt	complete
involved_in	GO:1900924	negative regulation of glycine import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P	Seeded From UniProt	complete
involved_in	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P	Seeded From UniProt	complete
involved_in	GO:0060135	maternal process involved in female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P	Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	F	Seeded From UniProt	complete
involved_in	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	C	Seeded From UniProt	complete
involved_in	GO:0030728	ovulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P	Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P	Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	C	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	C	Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034947	F	Seeded From UniProt	complete
involved_in	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034947	P	Seeded From UniProt	complete
involved_in	GO:0008277	regulation of G protein-coupled receptor signaling pathway	PMID:10747990^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:10747990^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:10747990^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8982026 Reactome:R-HSA-8982025 Reactome:R-HSA-8982017	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	Reactome:R-HSA-8982025	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0343	F	Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0734	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Chatterjee, TK & Fisher, RA (2000) Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs. J. Biol. Chem. 275 24013-21 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Kimple, AJ et al. (2009) Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). J. Biol. Chem. 284 19402-11 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Heximer, SP et al. (2001) Mechanisms governing subcellular localization and function of human RGS2. J. Biol. Chem. 276 14195-203 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Popov, SG et al. (2000) Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity. J. Biol. Chem. 275 18962-8 PubMed GONUTS page

[PMID:10791963-1] 1.0 ^1.1 Chatterjee, TK & Fisher, RA (2000) Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs. J. Biol. Chem. 275 24013-21 PubMed GONUTS page

[PMID:19478087-2] 2.0 ^2.1 ^2.2 Kimple, AJ et al. (2009) Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). J. Biol. Chem. 284 19402-11 PubMed GONUTS page

[PMID:11278586-3] 3.0 ^3.1 ^3.2 Heximer, SP et al. (2001) Mechanisms governing subcellular localization and function of human RGS2. J. Biol. Chem. 276 14195-203 PubMed GONUTS page

[PMID:10747990-4] 4.0 ^4.1 ^4.2 Popov, SG et al. (2000) Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity. J. Biol. Chem. 275 18962-8 PubMed GONUTS page

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HUMAN:RGS2

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