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HUMAN:RGS10
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | RGS10 | |
| Protein Name(s) | Regulator of G-protein signaling 10
RGS10 | |
| External Links | ||
| UniProt | O43665 | |
| EMBL | AF368902 AF045229 AF493934 AK290773 CR457008 AL355273 AC012468 AL355273 CH471066 CH471066 BC009361 | |
| CCDS | CCDS31294.1 CCDS41572.1 | |
| PIR | S71812 | |
| RefSeq | NP_001005339.1 NP_002916.1 | |
| UniGene | Hs.501200 | |
| PDB | 2DLR 2I59 2IHB | |
| PDBsum | 2DLR 2I59 2IHB | |
| ProteinModelPortal | O43665 | |
| SMR | O43665 | |
| BioGrid | 111933 | |
| DIP | DIP-50368N | |
| STRING | 9606.ENSP00000358099 | |
| OGP | O43665 | |
| MaxQB | O43665 | |
| PaxDb | O43665 | |
| PRIDE | O43665 | |
| DNASU | 6001 | |
| Ensembl | ENST00000369101 ENST00000369103 ENST00000392865 | |
| GeneID | 6001 | |
| KEGG | hsa:6001 | |
| UCSC | uc001lee.3 uc001lef.3 uc001leg.3 | |
| CTD | 6001 | |
| GeneCards | GC10M121249 | |
| HGNC | HGNC:9992 | |
| HPA | CAB004559 HPA021305 | |
| MIM | 602856 | |
| neXtProt | NX_O43665 | |
| PharmGKB | PA34362 | |
| eggNOG | NOG271158 | |
| GeneTree | ENSGT00760000119142 | |
| HOGENOM | HOG000233512 | |
| HOVERGEN | HBG013233 | |
| InParanoid | O43665 | |
| KO | K16449 | |
| OMA | PKSTAKW | |
| OrthoDB | EOG7XDBF0 | |
| PhylomeDB | O43665 | |
| TreeFam | TF315837 | |
| Reactome | REACT_19231 | |
| SignaLink | O43665 | |
| ChiTaRS | RGS10 | |
| EvolutionaryTrace | O43665 | |
| GeneWiki | RGS10 | |
| GenomeRNAi | 6001 | |
| NextBio | 23399 | |
| PMAP-CutDB | O43665 | |
| PRO | PR:O43665 | |
| Proteomes | UP000005640 | |
| Bgee | O43665 | |
| CleanEx | HS_RGS10 | |
| Genevestigator | O43665 | |
| GO | GO:0043679 GO:0005737 GO:0043197 GO:0043025 GO:0005634 GO:0005886 GO:0005096 GO:0043547 GO:0038032 | |
| Gene3D | 1.10.196.10 | |
| InterPro | IPR016137 IPR024066 | |
| Pfam | PF00615 | |
| PRINTS | PR01301 | |
| SMART | SM00315 | |
| SUPFAM | SSF48097 | |
| PROSITE | PS50132 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005096 |
GTPase activator activity |
ECO:0000314 |
F |
Figure 3 shows RGS16 activates GFP by turning off Galpha and Gbeta quicker,as seen in the overlay (yellow) in flourescence picture shows the activation of GFP. |
complete | |||||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Fig.2 |
complete | |||||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001965 |
G-protein alpha-subunit binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007213 |
G protein-coupled acetylcholine receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043679 |
axon terminus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49806 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043197 |
dendritic spine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49806 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49806 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49806 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001975 |
response to amphetamine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49806 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001965 |
G-protein alpha-subunit binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008277 |
regulation of G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
Reactome:R-HSA-388396 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-8982020 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0003924 |
GTPase activity |
Reactome:R-HSA-8982020 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009968 |
negative regulation of signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Chatterjee, TK & Fisher, RA (2000) Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs. J. Biol. Chem. 275 24013-21 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Soundararajan, M et al. (2008) Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc. Natl. Acad. Sci. U.S.A. 105 6457-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Burgon, PG et al. (2001) Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). J. Biol. Chem. 276 32828-34 PubMed GONUTS page
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