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HUMAN:RGS10

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RGS10
Protein Name(s) Regulator of G-protein signaling 10

RGS10

External Links
UniProt O43665
EMBL AF368902
AF045229
AF493934
AK290773
CR457008
AL355273
AC012468
AL355273
CH471066
CH471066
BC009361
CCDS CCDS31294.1
CCDS41572.1
PIR S71812
RefSeq NP_001005339.1
NP_002916.1
UniGene Hs.501200
PDB 2DLR
2I59
2IHB
PDBsum 2DLR
2I59
2IHB
ProteinModelPortal O43665
SMR O43665
BioGrid 111933
DIP DIP-50368N
STRING 9606.ENSP00000358099
OGP O43665
MaxQB O43665
PaxDb O43665
PRIDE O43665
DNASU 6001
Ensembl ENST00000369101
ENST00000369103
ENST00000392865
GeneID 6001
KEGG hsa:6001
UCSC uc001lee.3
uc001lef.3
uc001leg.3
CTD 6001
GeneCards GC10M121249
HGNC HGNC:9992
HPA CAB004559
HPA021305
MIM 602856
neXtProt NX_O43665
PharmGKB PA34362
eggNOG NOG271158
GeneTree ENSGT00760000119142
HOGENOM HOG000233512
HOVERGEN HBG013233
InParanoid O43665
KO K16449
OMA PKSTAKW
OrthoDB EOG7XDBF0
PhylomeDB O43665
TreeFam TF315837
Reactome REACT_19231
SignaLink O43665
ChiTaRS RGS10
EvolutionaryTrace O43665
GeneWiki RGS10
GenomeRNAi 6001
NextBio 23399
PMAP-CutDB O43665
PRO PR:O43665
Proteomes UP000005640
Bgee O43665
CleanEx HS_RGS10
Genevestigator O43665
GO GO:0043679
GO:0005737
GO:0043197
GO:0043025
GO:0005634
GO:0005886
GO:0005096
GO:0043547
GO:0038032
Gene3D 1.10.196.10
InterPro IPR016137
IPR024066
Pfam PF00615
PRINTS PR01301
SMART SM00315
SUPFAM SSF48097
PROSITE PS50132

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005096

GTPase activator activity

PMID:10791963[1]

ECO:0000314

F

Figure 3 shows RGS16 activates GFP by turning off Galpha and Gbeta quicker,as seen in the overlay (yellow) in flourescence picture shows the activation of GFP.

complete
CACAO 6503

GO:0005634

nucleus

PMID:10791963[1]

ECO:0000314

C

Fig.2

complete
CACAO 6947

enables

GO:0005096

GTPase activator activity

PMID:18434541[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

PMID:18434541[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001965

G-protein alpha-subunit binding

PMID:18434541[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P08754

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11443111[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:11443111[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

PMID:11443111[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007213

G protein-coupled acetylcholine receptor signaling pathway

PMID:11443111[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10791963[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043679

axon terminus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49806
ensembl:ENSRNOP00000027375

C

Seeded From UniProt

complete

part_of

GO:0043197

dendritic spine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49806
ensembl:ENSRNOP00000027375

C

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49806
ensembl:ENSRNOP00000027375

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49806
ensembl:ENSRNOP00000027375

C

Seeded From UniProt

complete

involved_in

GO:0001975

response to amphetamine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49806
ensembl:ENSRNOP00000027375

P

Seeded From UniProt

complete

enables

GO:0001965

G-protein alpha-subunit binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037879

F

Seeded From UniProt

complete

involved_in

GO:0008277

regulation of G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037879

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-8982020
Reactome:R-HSA-8982019
Reactome:R-HSA-8982012

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

Reactome:R-HSA-8982020

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009968

negative regulation of signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0734

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0343

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Chatterjee, TK & Fisher, RA (2000) Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs. J. Biol. Chem. 275 24013-21 PubMed GONUTS page
  2. 2.0 2.1 2.2 Soundararajan, M et al. (2008) Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc. Natl. Acad. Sci. U.S.A. 105 6457-62 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Burgon, PG et al. (2001) Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). J. Biol. Chem. 276 32828-34 PubMed GONUTS page